Delivery of curcumin by shellac encapsulation: Stability, bioaccessibility, freeze-dried redispersibility, and solubilization

Yuan, Yongkai; Zhang, Shuaizhong; Ma, Mengjie; Xu, Ying; Wang, Dongfeng

doi:10.1016/j.fochx.2022.100431

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…As shown in Figure 4 d, the CU contents of nanoparticles prepared from two polymers were gradually enhanced with an increase in CS content ( p ˂ 0.05). The extent of CU content enhancement in this study was comparable to a previous study on the shellac encapsulation of CU [ 83 ]. While there was no significant difference between CU contents between nanoparticles prepared from CH:CS at 5:0 and CH:CS at 3:2, there were significant differences between the mean particle size, PDI, and zeta potential values described above ( p ˂ 0.05).…”

Section: Resultssupporting

confidence: 89%

Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin

2023

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This study aimed to separate chondroitin sulfate (CS) from the heads of skipjack tuna (Katsuwonus pelamis) and yellowfin tuna (Thunnus albacares), by-products derived from canned tuna processing, via a biological process. The use of 1% w/w papain and an incubation time of 48 h resulted in a degree of hydrolysis of 93.75 ± 2.94% and a CS content of 59.53 ± 1.77 mg/100 g. The FTIR spectra of extracted CS products exhibited identical functional groups found in commercially available CS. The molecular weights of CS extracted from skipjack and yellowfin tuna heads were 11.0 kDa and 7.7 kDa, respectively. Subsequently, a CH:CS ratio of 3:2 for CS and chitooligosaccharides (CH) was chosen as the optimal ratio for the preparation of spherical nanoparticles, with %EE, mean particle size, PDI, and zeta potential values of 50.89 ± 0.66%, 128.90 ± 3.29 nm, 0.27 ± 0.04, and −12.47 ± 2.06, respectively. The CU content was enhanced to 127.21 ± 1.66 μg/mL. The release of CU from this particular nanosystem involved mainly a drug diffusion mechanism, with a burst release in the first 3 h followed by a sustained release of CU over 24 h. The DPPH and ABTS scavenging activity results confirmed the efficient encapsulation of CU into CHCS nanoparticles. This study will provide a theoretical basis for CS derived from tuna head cartilages to be used as a functional component with specific functional properties in food and biomedical applications.

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Section: Resultssupporting

confidence: 89%

Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin

2023

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“…The decreased intensity of two major peaks of PF in COSPFCU confirmed the formation of polymeric micelles. In COSPFCU, the crystalline structures being in an amorphous state caused a significant decrease in intramolecular H-bonds before the conformation [47,48]. However, the XRD pattern of COSPFCU did not show the fingerprint of COS and CU due to the high concentration of PF and decrease of H-bonds in formation.…”

Section: X-ray Diffraction Analysis (Xrd)mentioning

confidence: 94%

Preparation and Primary Bioactivity Evaluation of Novel Water-Soluble Curcumin-Loaded Polymeric Micelles Fabricated with Chitooligosaccharides and Pluronic F-68

Ingrungruengluet,

Wang,

et al. 2023

Pharmaceutics

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Curcumin (CU) is a bioactive compound extracted from turmeric and has various advantages. However, the benefit of CU is limited by its low water solubility (11 ng/mL). This research aimed to fabricate a water-soluble CU nano-formulation with chitooligosaccharides (COS) and pluronic F-68 (PF) utilizing the polymeric micelle method. The optimized curcumin-loaded chitooligosaccharides/pluronic F-68 micelles (COSPFCU) exhibited high encapsulation efficiency and loading capacity (75.57 ± 2.35% and 10.32 ± 0.59%, respectively). The hydrodynamic diameter of lyophilized COSPFCU was 73.89 ± 11.69 nm with a polydispersity index below 0.3. The COSPFCU could be completely redispersed in water and showed high DPPH scavenging ability. Meanwhile, COSPFCU could significantly reduce the cytotoxicity of the RAW 264.7 cells compared to native CU. Furthermore, COSPFCU improved the inhibition of NO release activity at 72.83 ± 2.37% but 33.20 ± 3.41% for the CU, with a low cytotoxicity concentration in the RAW 264.7 cells.

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“…17 Manee et al used polyethylene glycol (PEG) as a plasticizer to stabilize the active groups of shellac by providing hydrogen bonding between the active components of shellac and the hydroxyl groups of PEG. 18 However, shellac and its modifiers are generally used as carriers to load some functional and active compounds in the packaging fields, 19 but shellac has rarely been used directly as a substrate to prepare the packing films due to its unsatisfactory solubility and mechanical properties. 6,[20][21][22][23] Therefore, it is necessary to prepare a shellac film with higher thermal stability and enhanced mechanical properties to give it additional functional properties.…”

Section: Introductionmentioning

confidence: 99%

High UV shielding and mechanical properties of shellac composite film for fruit packaging

Zhang,

Du,

Dong

et al. 2024

New J. Chem.

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Delivery of curcumin by shellac encapsulation: Stability, bioaccessibility, freeze-dried redispersibility, and solubilization

Cited by 6 publications

References 40 publications

Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin

Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin

Preparation and Primary Bioactivity Evaluation of Novel Water-Soluble Curcumin-Loaded Polymeric Micelles Fabricated with Chitooligosaccharides and Pluronic F-68

High UV shielding and mechanical properties of shellac composite film for fruit packaging

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