Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer

Nair, Hareesh B.; Sung, Bokyung; Yadav, Vivek R.; Kannappan, Ramaswamy; Chaturvedi, Madan M.; Aggarwal, Bharat B.

doi:10.1016/j.bcp.2010.07.021

Cited by 242 publications

(134 citation statements)

References 124 publications

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“…1 Medical applications is a sector where nanomaterials have shown great potential and have already been used in several areas including: in vivo and in vitro diagnostic tools, biocompatible materials for implants, nutraceuticals, cancer therapy and, in particular, drug delivery. [2][3][4][5][6][7][8] In terms of drug delivery, this interest is due to properties such as the ability to cross biological barriers easier than some more traditional delivery vehicles and the potential to escape from intracellular compartments such as lysosomes and endosomes. 9 A full list of properties and potential uses for nanoparticles in drug delivery is somewhat outside the scope of this paper and has been reviewed elsewhere (De Jong et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Numerical simulations of in vitro nanoparticle toxicity – The case of poly(amido amine) dendrimers

Maher¹,

Naha²,

Mukherjee³

et al. 2014

Toxicology in Vitro

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A phenomenological rate equation model is constructed to numerically simulate nanoparticle uptake and subsequent cellular response. Polyamidoamine dendrimers (generations 4-6) are modelled and the temporal evolution of the intracellular cascade of; increased levels of reactive oxygen species, intracellular antioxidant species, caspase activation, mitochondrial membrane potential decay, tumour necrosis factor and interleukin generation is simulated, based on experimental observations. The model serves as a tool to interpolate and visualise the range of dose and temporal dependences and elucidate the mechanisms underlying the in vitro cytotoxic response to nanoparticle exposure and describes the interaction in terms of independent nanoparticle properties and cellular parameters, based on reaction rates. Such an approach could be a valid alternative to that of effective concentrations for classification of nanotoxicity and may lay the foundation for future quantitative structure activity relationships and predictive nanotoxicity models.3

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Section: Introductionmentioning

confidence: 99%

Numerical simulations of in vitro nanoparticle toxicity – The case of poly(amido amine) dendrimers

Maher¹,

Naha²,

Mukherjee³

et al. 2014

Toxicology in Vitro

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“…[33][34][35] As shown in Table 1, the C-PEG-SLNs and DSPE-PEG-SLNs exhibit a mono-modal particle size distribution with the D h values in the range 100-110 nm, pertinent for passive targeting to tumor by the EPR effect (#200 nm) 3,33 and for avoiding elimination by kidneys ($10 nm). 36 The transmission electronic microscopy images illustrate that the SLNs were solid spherical particles without aggregation (Figure 2). The SLNs exhibited neutral zeta potentials of 0.7-3.3 mV, due to the presence of PEG-derived coating as the stealth system on the surfaces of SLNs, which could further enhance storage stability and reduce albumin-associated aggregation in blood circulation, 36,37 as the prerequisites for practical applications.…”

Section: Preparation and Characterization Of Slnsmentioning

confidence: 99%

“…36 The transmission electronic microscopy images illustrate that the SLNs were solid spherical particles without aggregation (Figure 2). The SLNs exhibited neutral zeta potentials of 0.7-3.3 mV, due to the presence of PEG-derived coating as the stealth system on the surfaces of SLNs, which could further enhance storage stability and reduce albumin-associated aggregation in blood circulation, 36,37 as the prerequisites for practical applications. This is supported by the results of DLS analysis showing that the SLNs maintained their original particle sizes after long-term storage (~5 weeks) in high ionic strength (0.15 M) PBS buffer ( Figure S4A).…”

Section: Preparation and Characterization Of Slnsmentioning

confidence: 99%

pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

Chen¹,

Huang²,

Chiang³

et al. 2015

IJN

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In this study, a novel pH-responsive cholesterol-PEG adduct-coated solid lipid nanoparticles (C-PEG-SLNs) carrying doxorubicin (DOX) capable of overcoming multidrug resistance (MDR) breast cancer cells is presented. The DOX-loaded SLNs have a mean hydrodynamic diameter of ~100 nm and a low polydispersity index (under 0.20) with a high drug-loading efficiency ranging from 80.8% to 90.6%. The in vitro drug release profiles show that the DOX-loaded SLNs exhibit a pH-controlled drug release behavior with the maximum and minimum unloading percentages of 63.4% at pH 4.7 and 25.2% at pH 7.4, respectively. The DOX-loaded C-PEG-SLNs displayed a superior ability in inhibiting the proliferation of MCF-7/MDR cells. At a DOX concentration of 80 μM, the cell viabilities treated with C-PEG-SLNs were approximately one-third of the group treated with free DOX. The inhibition activity of C-PEG-SLNs could be attributed to the transport of C-PEG to cell membrane, leading to the change of the composition of the cell membrane and thus the inhibition of permeability glycoprotein activity. This hypothesis is supported by the confocal images showing the accumulation of DOX in the nuclei of cancer cells and the localization of C-PEG on the cell membranes. The results of in vivo study further demonstrated that the DOX delivered by the SLNs accumulates predominantly in tumor via enhanced permeability and retention effect, the enhanced passive tumor accumulation due to the loose intercellular junctions of endothelial cells lining inside blood vessels at tumor site, and the lack of lymphatic drainage. The growth of MCF-7/MDR xenografted tumor on Balb/c nude mice was inhibited to ~400 mm 3 in volume as compared with the free DOX treatment group, 1,140 mm 3 , and the group treated with 1,2 distearoyl-sn-glycero-3-phosphoethanolamine- N -[methoxy(polyethylene glycol)] solid lipid nanoparticles, 820 mm 3 . Analysis of the body weight of nude mice and the histology of organs and tumor after the administration of DOX-loaded SLNs show that the SLNs have no observable side effects. These results indicate that the C-PEG-SLN is a promising platform for the delivery of therapeutic agents for MDR cancer chemotherapy.

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“…Herbs have also been recognized to possess medicinal properties [19]. The herbal therapies with high phenolic content are preponderant in the West Africa especially the tropical Africa [20,21].…”

Section: Introductionmentioning

confidence: 99%

PUFAs from Stem Bark of Alstonia boonei Synergistically Modulates Diabetic, Hepatic and Androgenic Damage by Low Expression of COX-2 and iNOS in Rats

Ajiboye¹,

Akintunde²,

So³

et al. 2017

J Mol Biomark Diagn

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PUFAs, from the stem bark extract of Alstonia boonei (SBEAB) was hypothesized to possess anti-inflammatory, antioxidant, anti-diabetic, pro-spermatogenic and hepatoprotective activities. The present study investigated the possible biochemical and molecular mechanisms underlying the hepatoprotective and testoprotective effects of SBEAB in diabetic rat. Biomarkers of hepatic and testicular damage, histological and immunohistochemical techniques were used. The expression of cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) were also estimated. SBEAB administered orally at dose of 100 mg/kg for 14 days significantly lowered the activities of serum transaminases and MDA levels induced by single intraperitoneal administration of streptozotoxin (STREP) (80 mg/kg) and preserved the integrity of both hepatocytes and spermatocytes. Also, SBEAB elevated the STREPinduced reduced activities of Δ5-17β-HSD and Δ5-17β-HSD with corresponding decrease in the activity of CAT. SBEAB inhibited the STREP induced expression of COX-2 and iNOS. The protective effect of SBEAB was compared to that of metaglomide (METAG), an established anti-diabetic drug. METAG treatment on hepatic damage was most efficacious in diabetic rats; followed by post and pre-treatment respectively while pre-and post-treatment were more efficacious on testicular damage than anti-diabetic drug. Furthermore, pre and post-treatment were more efficacious in preventing pro-inflammation and testicular cancer in diabetic rats than METAG-administration. We therefore concluded that the repression of genes encoding COX-2 and iNOS proteins by SBEAB validates the molecular basis of testicular protection and further suggests the links between the hepatocellular damage and male reproductive dysfunctions in diabetic individuals.

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Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer

Cited by 242 publications

References 124 publications

Numerical simulations of in vitro nanoparticle toxicity – The case of poly(amido amine) dendrimers

Numerical simulations of in vitro nanoparticle toxicity – The case of poly(amido amine) dendrimers

pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

PUFAs from Stem Bark of Alstonia boonei Synergistically Modulates Diabetic, Hepatic and Androgenic Damage by Low Expression of COX-2 and iNOS in Rats

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