Delirium

Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features

“…The resolution of delirium symptoms accompanied by the qualitative reversal of EEG abnormalities was first described in 1944 during correction of various underlying etiologies. 32 More recently, changes in Mini-Mental Status Exam scores were correlated with relative EEG power measures across serial recordings separated by weeks. 33 Since these early reports, there have been limited data in the longitudinal evaluation of quantitative EEG markers during the progression of delirium.…”

“…6–9,11–13 “EEG slowing” has long been associated with delirium and encephalopathies of various etiologies. 32 However, previous prospective studies have focused on single EEG recordings, leaving EEG trajectories largely unexplored. Our serial measurements of patients recovering from delirium likely included subsyndromal states, which may account for the lower discriminative capacity in our study compared to those focusing on single measurements from high-risk patients during a shorter postoperative period.…”

Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features

“…The resolution of delirium symptoms accompanied by the qualitative reversal of EEG abnormalities was first described in 1944 during correction of various underlying etiologies. 32 More recently, changes in Mini-Mental Status Exam scores were correlated with relative EEG power measures across serial recordings separated by weeks. 33 Since these early reports, there have been limited data in the longitudinal evaluation of quantitative EEG markers during the progression of delirium.…”

“…6–9,11–13 “EEG slowing” has long been associated with delirium and encephalopathies of various etiologies. 32 However, previous prospective studies have focused on single EEG recordings, leaving EEG trajectories largely unexplored. Our serial measurements of patients recovering from delirium likely included subsyndromal states, which may account for the lower discriminative capacity in our study compared to those focusing on single measurements from high-risk patients during a shorter postoperative period.…”

Electrical Activity of the Brain

“…They fail to emphasize that so Iow a cut-off is highly disadvanta geous and they say nothing about the extent to which the instru ments tested were free from sways due to flu' ctuations in line volt age. ' Two types of wave indices (233,234) and a frequency spectrum GIBBS obtained by counting'the waves in a given length of record (178,179) have been advocated as quantitative methods of tabulating and presenting data. Cohn (235) has suggested the use of a fre quency analyzer such as is employed for the stud y of tree rings .…”

The Pathophysiology and Biomarkers of Delirium

“…Multifunction protein expressed by glial cells; higher values associated with fewer delirium-and coma-free days, and longer delirium during critical illness, 99 but not emergency department delirium 100 NSE (neuron-specific enolase) Cytosolic enzyme of neurons and neuroendocrine cells, and peripheral blood marker of neuronal injury; higher admission plasma levels associated with increased risk of ICU delirium; 102 greater increases observed in post-operative delirium 103,104 NFL (neurofilament light) Neuron-specific cytoskeletal protein; greater plasma increase associated with greater risk of postoperative delirium 105,106 EEG (electroencephalogram) Measure of coordinated patterns of neuronal firing; Decreases in variability, increases in low frequency oscillations associated with delirium risk, presence, and severity 22,28,32,[105][106][107] fMRI (functional magnetic resonance imaging)…”

“…Measure of blood oxygen level dependent changes; decreased network integration observed in hospitalized patients with delirium 108 and in postoperative delirium 109 current data include limited studies that share clinical triggers, varied clinical populations, and small sample sizes. It is also apparent that different diseases, medical states, and surgical interventions, as well as associated medications including anesthesia and analgesia, may be associated with correspondingly different biological markers.…”

Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features

“…The resolution of delirium symptoms accompanied by the qualitative reversal of EEG abnormalities was first described in 1944 during correction of various underlying etiologies. 32 More recently, changes in Mini-Mental Status Exam scores were correlated with relative EEG power measures across serial recordings separated by weeks. 33 Since these early reports, there have been limited data in the longitudinal evaluation of quantitative EEG markers during the progression of delirium.…”

“…6–9,11–13 “EEG slowing” has long been associated with delirium and encephalopathies of various etiologies. 32 However, previous prospective studies have focused on single EEG recordings, leaving EEG trajectories largely unexplored. Our serial measurements of patients recovering from delirium likely included subsyndromal states, which may account for the lower discriminative capacity in our study compared to those focusing on single measurements from high-risk patients during a shorter postoperative period.…”

Electrical Activity of the Brain

“…They fail to emphasize that so Iow a cut-off is highly disadvanta geous and they say nothing about the extent to which the instru ments tested were free from sways due to flu' ctuations in line volt age. ' Two types of wave indices (233,234) and a frequency spectrum GIBBS obtained by counting'the waves in a given length of record (178,179) have been advocated as quantitative methods of tabulating and presenting data. Cohn (235) has suggested the use of a fre quency analyzer such as is employed for the stud y of tree rings .…”

The Pathophysiology and Biomarkers of Delirium

“…Multifunction protein expressed by glial cells; higher values associated with fewer delirium-and coma-free days, and longer delirium during critical illness, 99 but not emergency department delirium 100 NSE (neuron-specific enolase) Cytosolic enzyme of neurons and neuroendocrine cells, and peripheral blood marker of neuronal injury; higher admission plasma levels associated with increased risk of ICU delirium; 102 greater increases observed in post-operative delirium 103,104 NFL (neurofilament light) Neuron-specific cytoskeletal protein; greater plasma increase associated with greater risk of postoperative delirium 105,106 EEG (electroencephalogram) Measure of coordinated patterns of neuronal firing; Decreases in variability, increases in low frequency oscillations associated with delirium risk, presence, and severity 22,28,32,[105][106][107] fMRI (functional magnetic resonance imaging)…”

“…Measure of blood oxygen level dependent changes; decreased network integration observed in hospitalized patients with delirium 108 and in postoperative delirium 109 current data include limited studies that share clinical triggers, varied clinical populations, and small sample sizes. It is also apparent that different diseases, medical states, and surgical interventions, as well as associated medications including anesthesia and analgesia, may be associated with correspondingly different biological markers.…”

Postoperative Delirium Severity and Recovery Correlate With Electroencephalogram Spectral Features

“…The resolution of delirium symptoms accompanied by the qualitative reversal of EEG abnormalities was first described in 1944 during correction of various underlying etiologies. 32 More recently, changes in Mini-Mental Status Exam scores were correlated with relative EEG power measures across serial recordings separated by weeks. 33 Since these early reports, there have been limited data in the longitudinal evaluation of quantitative EEG markers during the progression of delirium.…”

“…6–9,11–13 “EEG slowing” has long been associated with delirium and encephalopathies of various etiologies. 32 However, previous prospective studies have focused on single EEG recordings, leaving EEG trajectories largely unexplored. Our serial measurements of patients recovering from delirium likely included subsyndromal states, which may account for the lower discriminative capacity in our study compared to those focusing on single measurements from high-risk patients during a shorter postoperative period.…”

Electrical Activity of the Brain

“…They fail to emphasize that so Iow a cut-off is highly disadvanta geous and they say nothing about the extent to which the instru ments tested were free from sways due to flu' ctuations in line volt age. ' Two types of wave indices (233,234) and a frequency spectrum GIBBS obtained by counting'the waves in a given length of record (178,179) have been advocated as quantitative methods of tabulating and presenting data. Cohn (235) has suggested the use of a fre quency analyzer such as is employed for the stud y of tree rings .…”

The Pathophysiology and Biomarkers of Delirium

“…Multifunction protein expressed by glial cells; higher values associated with fewer delirium-and coma-free days, and longer delirium during critical illness, 99 but not emergency department delirium 100 NSE (neuron-specific enolase) Cytosolic enzyme of neurons and neuroendocrine cells, and peripheral blood marker of neuronal injury; higher admission plasma levels associated with increased risk of ICU delirium; 102 greater increases observed in post-operative delirium 103,104 NFL (neurofilament light) Neuron-specific cytoskeletal protein; greater plasma increase associated with greater risk of postoperative delirium 105,106 EEG (electroencephalogram) Measure of coordinated patterns of neuronal firing; Decreases in variability, increases in low frequency oscillations associated with delirium risk, presence, and severity 22,28,32,[105][106][107] fMRI (functional magnetic resonance imaging)…”

“…Measure of blood oxygen level dependent changes; decreased network integration observed in hospitalized patients with delirium 108 and in postoperative delirium 109 current data include limited studies that share clinical triggers, varied clinical populations, and small sample sizes. It is also apparent that different diseases, medical states, and surgical interventions, as well as associated medications including anesthesia and analgesia, may be associated with correspondingly different biological markers.…”