Amit Lalwani, Rebecca A. Stokes, Sue Mei Lau, Jenny E. Gunton
Abstract:BackgroundReplacing β-cells by islet-transplantation can cure type 1 diabetes, but up to 70% of β-cells die within 10 days of transplantation. ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates β-cell function, and potentially survival. Lack of ARNT impairs the ability of β-cells to respond to physiological stress and potentiates the onset of diabetes, but the exact role of ARNT in graft outcome is unknown.AimTo investigate the effect of β-cell deletion of ARNT on graft outcomes.MethodsIslets were…
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