2008
DOI: 10.1007/s00405-008-0784-8
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Abstract: Our aim was to determine whether histological changes occur in the cutaneous portion of pectoralis major Xaps employed for upper aero-digestive tract reconstruction and, if present, to characterize these changes and try to infer their cause. Seven patients submitted to repair of aerodigestive tract defects secondary to cancer resection with pectoralis major myocutaneous Xap were included in this study. All patients received adjuvant radiotherapy. Biopsies were taken from: the cutaneous portion of the Xap; bucc… Show more

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Cited by 8 publications
(9 citation statements)
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“…The majority of specimens in which fungal hyphae were isolated, were obtained from leukoplacic or erythematous lesions that appeared on the skin flap [9,10]. We and other authors were unable to prove the presence of fungi in any of our cases and this may be due to the fact that biopsies were performed from clinically normal skin areas [2,4,6]. However, candidiasis may be present even when hyphae are not histologically detectable [13].…”
Section: Discussionmentioning
confidence: 75%
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“…The majority of specimens in which fungal hyphae were isolated, were obtained from leukoplacic or erythematous lesions that appeared on the skin flap [9,10]. We and other authors were unable to prove the presence of fungi in any of our cases and this may be due to the fact that biopsies were performed from clinically normal skin areas [2,4,6]. However, candidiasis may be present even when hyphae are not histologically detectable [13].…”
Section: Discussionmentioning
confidence: 75%
“…Many authors have attempted to describe the histologic changes that occur in the intraorally placed skin. Most studies have been performed on free radial forearm flaps [3,7,[9][10][11], some studies have been performed on pectoralis major pedicled flaps [1,2] and some on skin grafts [5,12]. The final histologic appearance of the skin flap depends on the degree of inflammation, although the factors that induce this inflammation are not yet identified.…”
Section: Discussionmentioning
confidence: 99%
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“…32e34 Various histopathological changes were observed as the flap adapted to the new location, such as disappearance of the horny layer or a decrease in the amount of cutaneous appendages. 35 The authors investigated the histological change in the flap skin after it was transferred to the plantar region where it is exposed to constant pressure and shearing forces. The thicknesses of the epidermis and the dermis in the pressured region of the transferred flaps were greater compared to those in the non-weight-bearing region of the same foot.…”
Section: Discussionmentioning
confidence: 99%