Delayed clamping of the umbilical cord after delivery and implications for public cord blood banking

Allan, David S.; Scrivens, Nicholas; Lawless, Tiffany; Mostert, Karen; Oppenheimer, Lawrence; Walker, Mark; Petraszko, Tanya; Elmoazzen, Heidi

doi:10.1111/trf.13424

Cited by 38 publications

(24 citation statements)

References 10 publications

(11 reference statements)

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“…The effect of delayed clamping on the UCB quality was reported by Allan and colleagues . These authors have indicated some negative correlation between the volume and the TNC amount when clamping is delayed.…”

Section: Highlighted Factorsmentioning

confidence: 76%

“…The effect of delayed clamping on the UCB quality was reported by Allan and colleagues. 72 These authors have indicated some negative correlation between the volume and the TNC amount when clamping is delayed. It is important to take this correlation into account, even though its study has received little attention so far, because delayed clamping has been recommended by pediatricians and may therefore become widespread.…”

Section: Delayed Umbilical Cord Clampingmentioning

confidence: 98%

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Associated factors of umbilical cord blood collection quality

et al. 2017

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After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection.

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Section: Highlighted Factorsmentioning

confidence: 76%

Section: Delayed Umbilical Cord Clampingmentioning

confidence: 98%

Associated factors of umbilical cord blood collection quality

et al. 2017

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“…Indeed, DCC cannot be performed in all cases such as deliveries involving neonatal or maternal distress that require more immediate attention to the mother and/or neonate. While DCC significantly impacts the number of units that can be banked, it remains possible to collect units that meet thresholds for banking despite the practice of DCC …”

Section: Discussionmentioning

confidence: 99%

Reducing ethnic disparity in access to high‐quality HLA‐matched cord blood units for transplantation: analysis of the Canadian Blood Services' Cord Blood Bank inventory

et al. 2019

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BACKGROUND Launched in 2013, Canadian Blood Services' Cord Blood Bank (CBS' CBB) has built a high‐quality, ethnically diverse cord blood repository that aims to reduce ethnic disparity in accessing suitable units for transplantation. METHODS AND RESULTS As of December 2016, 2000 units have been banked. The self‐reported maternal ethnicity was 58% non‐Caucasian. Overall, 26% of units were classified as multi‐ethnicity with Caucasian (84%) most frequently observed in combination with Asian, First Nations (predominant indigenous peoples in Canada south of the Arctic Circle), or African ethnicity. Utilization scores that incorporate total nucleated and CD34+ cell counts in the CBS' CBB were associated with greater likelihood of utilization compared with the international inventory of units (p < 0.05). The distribution of utilization scores was similar for Caucasians compared with non‐Caucasians (p < 0.05). Using HLA genotypes of cord blood units and their mothers, we determined probable ethnic assignments for each haplotype using HaploStats (National Marrow Donor Program). Significant increases in HLA‐match likelihoods are predicted for all ethnicities as the inventory grows to its target of 10,000 units and the gap in HLA‐match likelihoods for Caucasian and non‐Caucasian patients progressively declines. CONCLUSIONS The CBS' CBB inventory is predicted to have high HLA‐matching likelihoods across a broad spectrum of ethnic groups, improving access to high‐quality stem cell products for all patients.

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“…Hesitancy arises from the lack of consensus on optimal timing for DCC and theorised risks such as potential volume overload, polycythaemia, jaundice and interruption of collection of blood for cord blood banking 20 42 74. Concerns about delayed resuscitation, thermal care and technical difficulties are being addressed through the development and trialling of new equipment to allow transition to be assisted closer to the mother with the cord intact 75 76.…”

Section: Postnatal Interventionsmentioning

confidence: 99%

Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

Lea

Smith-Collins

Luyt

2016

Arch Dis Child Fetal Neonatal Ed

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. INTRODUCTIONSurvival rates for preterm babies are increasing, 1 however severe neurological impairment remains a significant consequence of preterm birth.2 3 Research continues into potential treatments for reducing both the risk of initial brain injury and subsequent neurodevelopmental problems; 4 however, in the interim, these can be reduced by optimising currently approved and recommended practices.

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Delayed clamping of the umbilical cord after delivery and implications for public cord blood banking

Abstract: Delayed cord clamping greatly diminishes the volume and TNC count of units collected for a public cord blood bank. Creating an inventory of CBUs with high TNC content may take more time than expected.

Cited by 38 publications

References 10 publications

Associated factors of umbilical cord blood collection quality

Associated factors of umbilical cord blood collection quality

Reducing ethnic disparity in access to high‐quality HLA‐matched cord blood units for transplantation: analysis of the Canadian Blood Services' Cord Blood Bank inventory

Protecting the premature brain: current evidence-based strategies for minimising perinatal brain injury in preterm infants

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