Delayed circadian rhythms in older Africans living with human immunodeficiency virus (HIV)

Kn, Redman; Ke, O'Brien; Fs, Ruiz; DE, Rae; Gómez-Olivé, F Xavier; M, von Schantz; Scheuermaier, Karine

doi:10.1111/jpi.12838

Cited by 6 publications

(2 citation statements)

References 28 publications

(67 reference statements)

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“… 62 Importantly, rhythmic activities such as sleep/wake patterns change with increasing age, 63 consistent with reports of disturbed sleep in HIV infection 64 , 65 and delayed circadian rhythms in older Africans living with HIV. 66 Our study shows a direct circadian regulation of HIV replication and highlights the complex interplay among the clock, aging, and sleep in HIV therapy.…”

Section: Discussionmentioning

confidence: 65%

Molecular components of the circadian clock regulate HIV-1 replication

et al. 2023

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Section: Discussionmentioning

confidence: 65%

Molecular components of the circadian clock regulate HIV-1 replication

et al. 2023

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“…A recent study of older adults in Africa assessed actigraphy and salivary dim light melatonin onset data for sleep timing and reported an earlier than optimal sleep phase among n = 36 PLWH relative to n = 151 HIV‐negative participants [87]. This was the first report of a potential lifestyle‐independent circadian misalignment for PLWH.…”

Section: Inappropriate Sleep Timing Among Plwhmentioning

confidence: 99%

Sleep deficiency among people living with human immunodeficiency virus: A growing challenge

2023

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Purpose of reviewThe purpose of this narrative review is to consolidate and summarize the existing literature on sleep deficiency among people living with human immunodeficiency virus (HIV; PLWH), to discuss the potential impact of antiretroviral therapy on sleep deficiency and to identify priorities for future research in this area.Recent findingsThree important domains of sleep deficiency include alterations in sleep quality (including sleep disorders), duration and timing. The existing HIV and sleep deficiency literature, which is robust for sleep quality but sparser for sleep duration or sleep timing, has identified epidemiological correlates and outcomes associated with sleep deficiency including sociodemographic factors, HIV‐specific factors, aspects of physical and mental health and cognition.SummarySleep deficiency is a common problem among PLWH and is likely underdiagnosed, although more high‐quality research is needed in this area. Sleep quality has received the most attention in the literature via methodologies that assess subjective/self‐reported sleep quality, objective sleep quality or both. There is significantly less research on sleep duration and minimal research on sleep timing. Use of certain antiretroviral therapy drugs may be associated with sleep deficiency for some individuals. Future research should utilize larger, longitudinal studies with consistent, comprehensive and validated methods to assess both subjective and objective measures of sleep deficiency to better understand the prevalence, correlates and clinical implications of sleep deficiency in PLWH.

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