Dehydrozingerone and isoeugenol as inhibitors of lipid peroxidation and as free radical scavengers

Rajakumar, D.; Rao, M. N. A.

doi:10.1016/0006-2952(93)90649-h

Cited by 112 publications

(63 citation statements)

References 20 publications

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“…Dehydrogingerone showed mild inhibition of lipid peroxidation by acting as a free radical scavenger (Rajkumar & Rao 1993). Gingerol, the pungent factor in ginger oleoresin, inhibited phospholipids peroxidation induced by the FeCl 3 ascorbate system (Aeschbach et al 1994).…”

Section: Zingiber Officinale Roscmentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.ARTICLE HISTORY

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Section: Zingiber Officinale Roscmentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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“…This observation was in agreement with the structural requirement for activity on flavonoids (Pietta 2000); the 3′-O-methoxy-4′-hydroxy substitution on the aromatic ring was also demonstrated to exhibit radical scavenger activity. Dehydrozingerone showed mild inhibition of lipid per oxidation by acting as free radical scavenger (Rajkumar and Rao 1993). The antioxidant activity has been attributed to various mechanisms, among which are the prevention of chain initiation, the binding of transition metal ion catalysts, decomposition of peroxides, the prevention of continued hydrogen abstraction, the reductive capacity and radical scavenging.…”

Section: In-vitro Antioxidant Activity Studiesmentioning

confidence: 99%

“…Dehydrozingerone (DZ), a phenolic compound, isolated from ginger rhizomes (De Bernardi et al 1976;Motohashi et al 1997) is the structural half analogue of curcumin (major compound from turmeric rhizomes). DZ have a similar structure as isoeugenol (acetyl in place of methyl group) and both are known to be prominent bioactive compounds (Rajkumar and Rao 1993). Recently, studies are focused on the structureactivity relationships (SARS) (Motohashi et al 2000;Ohtsu et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds

2011

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Dehydrozingerone, structural half analogue of curcumin, is a phenolic compound isolated from ginger (Zingiber officinale) rhizomes. Dehydrozingerone and several of its derivatives such as glucopyranosides and its tetra acetate derivative and 4-O-acetyl and methyl derivatives of dehydrozingerone were synthesized in the present study. Dehydrozingerone, synthesised with improved yield was used for the synthesis of Dehydrozingerone 4-O-β-Dglucopyranoside (first time report) by modified KoenigsKnorr-Zemplén method. Structures of all the compounds have been established using spectroscopic methods. These compounds were tested for radical scavenging activity by DPPH and FRAP method as well as for antibacterial and antifungal activities. The parent molecule exhibited better scavenging activity as compared to its derivatives indicating the significance of free phenolic hydroxyl group. Also, Dehydrozingerone and its derivatives exhibited antibacterial as well as antifungal activity due to the conjugation system present, which includes α,β-unsaturated carbonyl (C = O) group. This study gave an insight into structural requirements for dehydrozingerone activity.

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“…More studies revealed that Ocimum sanctum decreased lipid peroxidation and increased the activity of SOD [17]. Eugenol and ursolic acid from Ocimum sanctum have been reported to induce protection against free radical induced cellular damage [18,19]. Keeping in view the pharmacological properties of Ocimum, present investigation has been undertaken to assess the antioxidant effect of Ocimum sanctum extract on cadmium induced oxidative stress in albino rats.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats

Ramesh

Satakopan

2010

Indian J Clin Biochem

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The present study was undertaken to analyze the antioxidant (both enzymic and nonenzymic) activities of leaves of Ocimum sanctum hydroalcoholic extract against cadmium induced damage in albino rats. Oral administration of cadmium as CdCl 2 (6.0 mg/kg body weight) led to significant elevation of lipid peroxidation (LPO) levels and significantly decreased Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx), Reduced Glutathione (GSH) and Vitamin C (Ascorbate) levels. Administration of Ocimum sanctum extract (100 mg/kg body weight, po) and (200 mg/kg body weight, po) before and after cadmium intoxication showed a significant decrease in LPO levels and significant increase in SOD, CAT, GPx, GSH and Ascorbate levels. The results suggest that oral administration of Ocimum sanctum extract provides significant protection against cadmium induced toxicity in Wistar albino rats.

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Dehydrozingerone and isoeugenol as inhibitors of lipid peroxidation and as free radical scavengers

Cited by 112 publications

References 20 publications

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds

Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats

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