Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis

Peixoto, Clayton; Grande, Antônio José; Mallmann, Mariana Bonotto; Nardi, Antônio Egídio; Cardoso, Adriana; Veras, André Barciela

doi:10.2174/1871527317666180817153914

Cited by 24 publications

(21 citation statements)

References 33 publications

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“…Our findings also support Girdler et al (24) suggestion that neuroactive steroids are mainly synthesized in the adrenals and that a history of depression may be associated with persistent adrenal suppression (24). Indeed, we show that the DHEA to CT ratio was significantly lower in depressed mothers compared to controls; it seems that DHEA secretion was even more sensitive than CT to allostatic pressures in depressed mothers, a finding that may be of interest when developing new therapeutic strategies for chronic maternal depression (9,12). There is some evidence that the beneficial effects of these agents are mediated by the regulation of the HPA axis (48).…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, these hormones seem to have some therapeutic value (11). In a recent meta-analysis, there seem to be a significant treatment effect for these hormones in depression when compared to placebo (12) and DHEA and DHEA-s were found to influence basic electrophysiological processes. An interest finding in this regard is that depression is accompanied by an attenuated DHEA and DHEA-S response to acute psychosocial stress, which may help elucidate the relationship between the HPA axis and stress (13).…”

Section: Introductionmentioning

confidence: 99%

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Chronic Depression Alters Mothers’ DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes

2020

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Maternal depression is a major public health problem that typically occurs in the period surrounding childbirth. The neurobiological mechanisms underlying maternal depression have been the focus of increasing research and studies pointed to the crucial role of the HPA axis in this disorder. However, most studies focused on cortisol expression and regulation while recent attention has shifted to include the sulfate steroids DHEA and DHEA-S. A community cohort of 1,983 women with no comorbid risk was recruited at birth and depression was assessed periodically across the first postpartum year. At 6 years, 156 families were re-visited: 46 mothers were defined as chronically-depressed and 103 controls reported no depression from birth to six years. Mothers and children were diagnosed by structured psychiatric interviews and mother-child interactions were observed. Maternal diurnal cortisol (CT) and dehydroepiandrosterone (DHEA) were assessed. Depressed mothers had lower levels of DHEA (AUCg), flattened DHEA diurnal variability (AUCi), and smaller DHEA-to-CT Ratio. Regression analysis demonstrated that maternal sensitivity during mother-child interaction was independently predicted by maternal depression, DHEA levels, child CT, and child social withdrawal. Results underscore the need for multi-level understanding of the dynamic interplay between maternal psychopathology, mother-child relationship, and pituitary-adrenal-cortex-to-medulla balance in studying the cross generational transfer of psychiatric vulnerability from depressed mothers to their children.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Chronic Depression Alters Mothers’ DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes

2020

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“…Notably, neurosteroids with Sigma1R agonist properties demonstrate antidepressant-like activity [28,105,108,116,117], while progesterone prevents their effects [28,116]. DHEA has been shown to possess antidepressant effects when administered to patients with depressive disorders [118].…”

Section: Citaloprammentioning

confidence: 99%

Chaperone Sigma1R and Antidepressant Effect

Voronin

Vakhitova

Seredenin

2020

IJMS

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This review analyzes the current scientific literature on the role of the Sigma1R chaperone in the pathogenesis of depressive disorders and pharmacodynamics of antidepressants. As a result of ligand activation, Sigma1R is capable of intracellular translocation from the endoplasmic reticulum (ER) into the region of nuclear and cellular membranes, where it interacts with resident proteins. This unique property of Sigma1R provides regulation of various receptors, ion channels, enzymes, and transcriptional factors. The current review demonstrates the contribution of the Sigma1R chaperone to the regulation of molecular mechanisms involved in the antidepressant effect.

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“…Another RCT applying a 1-year DHEA treatment did also not reveal mood alleviating effects of DHEA in 110 men aged 55 to 85 years [88]. Additionally, there has been a recent yet somewhat questionable meta-analysis which included RCTs on DHEA supplementation suggesting beneficial effects of DHEA in depression [93]. However, based on these inconsistencies and the general shortage of empirical evidence, DHEA is not being considered as a potential antidepressant treatment in men.…”

Section: Mood and Depressive Disordersmentioning

confidence: 99%

Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?

Walther

Seuffert

2020

World J Mens Health

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of the World Federation of the Societies of Biological Psychiatry (WFSBP) Although demographic statistics show that populations around the world are rapidly ageing, this rising life expectancy is accompanied by an increase in the number of people living with age-related chronic conditions, such as frailty, cognitive decline, depression, or sexual dysfunction. In men, a progressive decline in androgens occurs with increasing age, and low androgen levels are associated with age-related chronic conditions. However, androgen administration studies are inconclusive, showing differing results according to the androgen used (testosterone [T], dehydroepiandrosterone [DHEA]), the group of men examined (younger vs. older; eugonadal vs. hypogonadal) and the conditions studied (frailty, cognitive decline, depression, sexual dysfunction). In this review, the current state for the use of T and DHEA therapy in men for the age-related conditions is examined. Due to the progressive age-related decline in androgens leading to a higher rate of older men having low androgen levels, the effects of androgen treatment in elderly males will be of particular interest in this review. Doseresponse relationships, the role of potential moderators, and the androgen treatment-related risk for adverse events will be discussed. Studies have suggested that T treatment-more so than DHEA treatment-may be an effective therapy against agerelated chronic conditions in men with low T levels; especially older men. Such conditions include frailty, depression, or sexual dysfunction. However, T treatment does not emerge as an effective therapy against cognitive decline. Nevertheless, more high-quality, randomised controlled trials using T treatment for age-related chronic conditions are necessary if further conclusions are to be made.

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Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis

Abstract: DHEA may be one more effective alternative between the drugs used in the treatment of depression.

Cited by 24 publications

References 33 publications

Chronic Depression Alters Mothers’ DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes

Chronic Depression Alters Mothers’ DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes

Chaperone Sigma1R and Antidepressant Effect

Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?

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