Dehydrobufotenin extracted from the Amazonian toad Rhinella marina (Anura: Bufonidae) as a prototype molecule for the development of antiplasmodial drugs

Enhancing Neuronal Networks with Rhinella schneideri Skin Secretion Molecules: Implications for Neurodegenerative Disorders

“…Due to their amphipathic nature, these subfractions may contain the same molecules that were not completely separated during the liquid–liquid partition. For instance, marinobufagin and bufalin are steroidal compounds that possess some solubility in aqueous media, as estimated from their molecular structures [ 24 ]. All molecules putatively identified in this study, except those with m / z 358 and m / z 405, have already been described in the literature as components of the parotid gland secretion of Rhinella schneideri .…”

Enhancing Neuronal Networks with Rhinella schneideri Skin Secretion Molecules: Implications for Neurodegenerative Disorders

“…Due to their amphipathic nature, these subfractions may contain the same molecules that were not completely separated during the liquid–liquid partition. For instance, marinobufagin and bufalin are steroidal compounds that possess some solubility in aqueous media, as estimated from their molecular structures [ 24 ]. All molecules putatively identified in this study, except those with m / z 358 and m / z 405, have already been described in the literature as components of the parotid gland secretion of Rhinella schneideri .…”

Bufadienolide Penetration Through the Skin Membrane and Antiaging Properties of Kalanchoe spp. Juices in Dermal Applications

“…Among plant families, Hyacinthaceae and Crassulaceae show the highest amount and diversity of bufadienolide compounds [ 23 , 24 , 43 , 44 , 45 , 46 ]. Those active constituents are tested for analgesic, antimicrobial, insecticidal, antiviral, antiplasmodial, antihypertensive, and cytotoxic activity [ 8 , 9 , 43 , 47 , 48 , 49 ]. As bufadienolides are pharmacologically highly active, depending on the type of compound and its dose, they might cause significant or even toxic effects for humans [ 50 ].…”

Antimalarial efficacy of Duttaphrynus melanostictus skin extract via inhibition of Plasmodium falciparum Na+/H+ ATPase

“…Three other bufadienolides, marinobufotoxin, marinobufagin, and bufalin, isolated from the secretion of R. marina were also documented of exhibiting anti-plasmodial activity against P. falciparum by interrupting the trophozoites development. The alkaloid dehydrobufotenine, isolated from the secretion of the same species also showed a strong inhibitory activity against the development of P. falciparum trophozoites (Ben et al 2021).…”

Enhancing Neuronal Networks with Rhinella schneideri Skin Secretion Molecules: Implications for Neurodegenerative Disorders

“…Due to their amphipathic nature, these subfractions may contain the same molecules that were not completely separated during the liquid–liquid partition. For instance, marinobufagin and bufalin are steroidal compounds that possess some solubility in aqueous media, as estimated from their molecular structures [ 24 ]. All molecules putatively identified in this study, except those with m / z 358 and m / z 405, have already been described in the literature as components of the parotid gland secretion of Rhinella schneideri .…”

Bufadienolide Penetration Through the Skin Membrane and Antiaging Properties of Kalanchoe spp. Juices in Dermal Applications

“…Among plant families, Hyacinthaceae and Crassulaceae show the highest amount and diversity of bufadienolide compounds [ 23 , 24 , 43 , 44 , 45 , 46 ]. Those active constituents are tested for analgesic, antimicrobial, insecticidal, antiviral, antiplasmodial, antihypertensive, and cytotoxic activity [ 8 , 9 , 43 , 47 , 48 , 49 ]. As bufadienolides are pharmacologically highly active, depending on the type of compound and its dose, they might cause significant or even toxic effects for humans [ 50 ].…”

Antimalarial efficacy of Duttaphrynus melanostictus skin extract via inhibition of Plasmodium falciparum Na+/H+ ATPase

“…Three other bufadienolides, marinobufotoxin, marinobufagin, and bufalin, isolated from the secretion of R. marina were also documented of exhibiting anti-plasmodial activity against P. falciparum by interrupting the trophozoites development. The alkaloid dehydrobufotenine, isolated from the secretion of the same species also showed a strong inhibitory activity against the development of P. falciparum trophozoites (Ben et al 2021).…”

Enhancing Neuronal Networks with Rhinella schneideri Skin Secretion Molecules: Implications for Neurodegenerative Disorders

“…Due to their amphipathic nature, these subfractions may contain the same molecules that were not completely separated during the liquid–liquid partition. For instance, marinobufagin and bufalin are steroidal compounds that possess some solubility in aqueous media, as estimated from their molecular structures [ 24 ]. All molecules putatively identified in this study, except those with m / z 358 and m / z 405, have already been described in the literature as components of the parotid gland secretion of Rhinella schneideri .…”

Bufadienolide Penetration Through the Skin Membrane and Antiaging Properties of Kalanchoe spp. Juices in Dermal Applications

“…Among plant families, Hyacinthaceae and Crassulaceae show the highest amount and diversity of bufadienolide compounds [ 23 , 24 , 43 , 44 , 45 , 46 ]. Those active constituents are tested for analgesic, antimicrobial, insecticidal, antiviral, antiplasmodial, antihypertensive, and cytotoxic activity [ 8 , 9 , 43 , 47 , 48 , 49 ]. As bufadienolides are pharmacologically highly active, depending on the type of compound and its dose, they might cause significant or even toxic effects for humans [ 50 ].…”

Antimalarial efficacy of Duttaphrynus melanostictus skin extract via inhibition of Plasmodium falciparum Na+/H+ ATPase

“…Three other bufadienolides, marinobufotoxin, marinobufagin, and bufalin, isolated from the secretion of R. marina were also documented of exhibiting anti-plasmodial activity against P. falciparum by interrupting the trophozoites development. The alkaloid dehydrobufotenine, isolated from the secretion of the same species also showed a strong inhibitory activity against the development of P. falciparum trophozoites (Ben et al 2021).…”