Degree of Differentiation in Nonproliferating Cells of Mammary Carcinoma

Wylie, C.V.; Nakane, Paul K.; Pierce, G. Barry

doi:10.1111/j.1432-0436.1973.tb00099.x

Cited by 24 publications

(7 citation statements)

References 10 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include desmosomes and tight junctions, intra-and inter-cellular ducts, microfilaments of various types, and well developed Golgi apparatus, dilated RER and numerous polyribosomes indicative of secretory activity [18,31,46]. These include desmosomes and tight junctions, intra-and inter-cellular ducts, microfilaments of various types, and well developed Golgi apparatus, dilated RER and numerous polyribosomes indicative of secretory activity [18,31,46].…”

Section: Ultr Astructur Al Featuresmentioning

confidence: 99%

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Barnett

Eccles

1984

Clin Exp Metast

View full text Add to dashboard Cite

The biological and metastatic properties of cells from a murine mammary adenocarcinoma, MT1, were studied during serial transplantation in syngeneic hosts. Over 35 generations the tumour progressed from a well-differentiated, poorly metastatic neoplasm to an anaplastic highly metastatic state. At early passages the tumour yielded uniform cultures of cuboidal epithelial cells, at passage 17 both epitheloid and spindle type cells were present, and by passage 30 only spindle type cells were obtained. Epithelioid cell lines and clones when injected intravenously into syngeneic hosts produced lung colonies only, whereas spindle cell lines were capable of extensive extrapulmonary colonisation. Similar patterns of dissemination and growth were seen in spontaneous metastasis assays. In spite of the marked phenotypic differences in these 'subpopulations', their comparable ultrastructural features, oestrogen receptor levels, expression of MMTV antigens, DNA content and lectin binding profiles suggested a common cell lineage. It is proposed that these cell lines will be of use in the determination of tumour and host factors influencing tumour progression and the evolution of metastatic potential.

show abstract

Section: Ultr Astructur Al Featuresmentioning

confidence: 99%

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Barnett

Eccles

1984

Clin Exp Metast

View full text Add to dashboard Cite

show abstract

“…Under specialṽ ivo or culture conditions, they even can revert to a II norma l" phenotype (Schubert~~, 1971;Wylie~~, 1973;Auersperg and Erber, 1976;Pierce et~, 1978;Sachs, 1978;Auersperg, 1978, etc.). Nevertheless, it is difficult to define conditions for modulation, so that the events bear some resemblance to the normal regulation.…”

Section: Quantity As a Tissue Specific And Developmental Markermentioning

confidence: 99%

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

Bissell

1981

International Review of Cytology

197

112

View full text Add to dashboard Cite

“…The recent observations of W ylie et al [25] provide a promising lead towards explaining the changes in cell cycle behavior which we have described here. They inspected mouse mammary adenocarcinoma cells and found that in addition to cells actively engaged in the cell cycle there were two non-mitotic cell pools.…”

Section: Discussionmentioning

confidence: 94%

Replication of Mouse Mammary Tumor Cells in Monolayer Cultures Stimulated with Embryo Extract

Baumann¹,

Hosick²

1978

Pathobiology

View full text Add to dashboard Cite

A particulate fraction derived from homogenized chicken embryos was added to primary monolayer cultures of mouse mammary tumor cells. All culture media contained fetal calf serum (10%). After 4 days, the extract had stimulated a twofold increase (relative to controls lacking the extract) in (1) total DNA per culture; (2) the rate of incorporation of labeled DNA precursors; (3) epithelial cell number, and (4) total protein. This integrated growth activity is discussed in terms of the nature and exogenous regulation of neoplastic growth.

show abstract

Degree of Differentiation in Nonproliferating Cells of Mammary Carcinoma

Cited by 24 publications

References 10 publications

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

Replication of Mouse Mammary Tumor Cells in Monolayer Cultures Stimulated with Embryo Extract

Contact Info

Product

Resources

About