Degradation rates and products of pure magnesium exposed to different aqueous media under physiological conditions

Kieke, Marc; Feyerabend, Frank; Lemaître, Jonathan; Behrens, Peter; Willumeit‐Römer, Regine

doi:10.1515/bnm-2015-0020

Cited by 33 publications

(31 citation statements)

References 28 publications

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“…Also in addition to results shown in Ref. we have observed Fe, Si, Nd, Mn, and Zn signals. These are expected to be artefacts from material production and handling, as none of these elements are contained in the culture medium.…”

Section: Discussionsupporting

confidence: 87%

“…As regions of P and Ca overlap (Figure C) the formation of hydroxyapatite is likely, which is supported by its high dissolution constant stated in Ref. . Further formation of calcite CaCO 3 and portlandite Ca(OH) 2 cannot be distinguished with the current measurements, due to technical limitations.…”

Section: Discussionsupporting

confidence: 68%

“…The elemental composition of the degradation layer suggests that in addition to the degradation products discussed in Ref. , calcium sulfate CaSO 4 is existent. There appears little probability for bobierrite (Mg 3 (PO 4 ) 2 ) to have precipitated, as Mg and P signals have little overlap (Figure C).…”

Section: Discussionmentioning

confidence: 91%

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Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time‐lapse SRµCT

Zeller‐Plumhoff

Helmholz

Feyerabend

et al. 2017

Materials & Corrosion

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Magnesium and its alloys have in recent years emerged as a promising alternative to titanium‐based implants for medical applications due to favorable degradation properties and good biocompatibility. The degradation of materials is currently investigated by studying different samples of the same material at different time points after degradation in a medium. This study is presenting a high‐resolution time‐lapse investigation of Mg‐2Ag in culture medium using synchrotron radiation‐based micro‐computed tomography over the course of 5 days. The design of the custom‐built corrosion cell and bioreactor are described. The computed degradation rate after 5 days is in agreement with the literature. SRµCT enables the segmentation of cracks forming in the degradation layer due to stresses and hydrogen development.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 68%

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Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time‐lapse SRµCT

Zeller‐Plumhoff

Helmholz

Feyerabend

et al. 2017

Materials & Corrosion

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“…The corrosion rates for Mg may differ depending on various parameters: the degree of its purity, heat treatment of the material, the type of electrolyte, the time of immersion, the crystal orientation, etc. [6,7,17,[26][27][28][29][30][31]. As reported, Mg in the high-purity form has the lowest corrosion rate, below 1 mlcm −2 day −1 .…”

Section: Evolution Of the Corrosion Reaction With Timementioning

confidence: 61%

“…The dimensions of the scales on the other samples are somewhat smaller, but are roughly of the same order of magnitude; thus, it can be tentatively concluded that thicknesses of the degradation layers are 10-100 µm. The surface morphology is typical of Mg alloys exposed to buffered SBF, e.g., [26,27]. SEM imaging of the surface was also attempted but, due to the strong charging of the surface, only two poor-quality SEM images were obtained, with brightness over-saturation on the upper surfaces ( Figure 6).…”

Section: Xps Of Samples After Sbf Immersionmentioning

confidence: 99%

Surface Analysis of Biodegradable Mg-Alloys after Immersion in Simulated Body Fluid

et al. 2020

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Two binary biodegradable Mg-alloys and one ternary biodegradable Mg-alloy (Mg-0.3Ca, Mg-5Zn and Mg-5Zn-0.3Ca, all in wt%) were investigated. Surface-sensitive X-ray photoelectron spectroscopy analyses (XPS) of the alloy surfaces before and after immersion in simulated body fluid (SBF) were performed. The XPS analysis of the samples before the immersion in SBF revealed that the top layer of the alloy might have a non-homogeneous composition relative to the bulk. Degradation during the SBF immersion testing was monitored by measuring the evolution of H2. It was possible to evaluate the thickness of the sample degradation layers after the SBF immersion based on scanning electron microscopy (SEM) of the tilted sample. The thickness was in the order of 10–100 µm. The typical bio-corrosion products of all of the investigated alloys consisted of Mg, Ca, P and O, which suggests the formation of apatite (calcium phosphate hydroxide), magnesium hydrogen phosphate hydrate and magnesium hydroxide. The bioapplicability of the analyzed alloys with regard to surface composition and degradation kinetics is discussed.

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Mg Biodegradation Mechanism Deduced from the Local Surface Environment under Simulated Physiological Conditions

González

Lamaka

Mei

et al. 2021

Adv Healthcare Materials

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Although certified magnesium-based implants are launched some years ago, the not well-defined Mg degradation mechanism under physiological conditions makes it difficult to standardize its use as a degradable biomaterial for a wide range of implant applications. Among other variables influencing the Mg degradation mechanism, monitoring the pH in the corrosive solution and, especially, at the corroding interface is important due to its direct relation with the formation and stability of the degradation products layer. The interface pH (pH at the Mg/solution interface) developed on Mg-2Ag and E11 alloys are studied in situ during immersion under dynamic conditions (1.5 mL min -1 ) in HBSS with and without the physiological amount of Ca 2+ cations (2.5 × 10 -3 m). The results show that the precipitation/dissolution of amorphous phosphate-containing phases, that can be associated with apatitic calcium-phosphates Ca 10-x (PO 4 ) 6-x (HPO 4 or CO 3 ) x (OH or ½ CO 3 ) 2-x with 0 ≤ x ≤ 2 (Ap-CaP), promoted in the presence of Ca 2+ generates an effective local pH buffering system at the surface. Thus, high alkalinization is prevented, and the interface pH is stabilized in the range of 7.6 to 8.5.

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Degradation rates and products of pure magnesium exposed to different aqueous media under physiological conditions

Cited by 33 publications

References 28 publications

Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time‐lapse SRµCT

Quantitative characterization of degradation processes in situ by means of a bioreactor coupled flow chamber under physiological conditions using time‐lapse SRµCT

Surface Analysis of Biodegradable Mg-Alloys after Immersion in Simulated Body Fluid

Mg Biodegradation Mechanism Deduced from the Local Surface Environment under Simulated Physiological Conditions

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