volume 17, issue 1, P739-779 1999
DOI: 10.1146/annurev.immunol.17.1.739
View full text
|
|
Share

Abstract: Major histocompatibility complex (MHC) class I molecules display on the cell surface 8- to 10-residue peptides derived from the spectrum of proteins expressed in the cells. By screening for non-self MHC-bound peptides, the immune system identifies and then can eliminate cells that are producing viral or mutant proteins. These antigenic peptides are generated as side products in the continual turnover of intracellular proteins, which occurs primarily by the ubiquitin-proteasome pathway. Most of the oligopeptide…

Expand abstract

Search citation statements

Order By: Relevance

Paper Sections

0
0
0
0
0

Citation Types

12
511
1
5

Publication Types

Select...

Relationship

0
0

Authors

Journals