Degradation of Binocular Coordination during Sleep Deprivation

Tong, Jianliang; Maruta, Jun; Heaton, Kristin J.; Maule, Alexis L.; Rajashekar, Umesh; Spielman, Lisa; Ghajar, Jamshid

doi:10.3389/fneur.2016.00090

Cited by 10 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies have shown that eyelid-closure/blink dynamics (e.g. Federal Highway Administration, 1998;Anderson et al 2013) and binocular gaze coordination (Horne, 1975;Tong et al 2016) are affected by fatigue or sleepiness, and that slow ocular drift accompanies the transition from wakefulness to sleep (Henn et al 1984;Santamaria and Chiappa, 1987;Ferrara et al 2000). Prior studies have also found altered saccadic eye movements associated with sleep deprivation.…”

Section: Relationship To Prior Literaturementioning

confidence: 99%

Distinct pattern of oculomotor impairment associated with acute sleep loss and circadian misalignment

Stone

Tyson

Cravalho

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

Key points Inadequate sleep and irregular work schedules have not only adverse consequences for individual health and well‐being, but also enormous economic and safety implications for society as a whole.This study demonstrates that visual motion processing and coordinated eye movements are significantly impaired when performed after sleep loss and during the biological night, and thus may be contributing to human error and accidents.Because affected individuals are often unaware of their sensorimotor and cognitive deficits, there is a critical need for non‐invasive, objective indicators of mild, yet potentially unsafe, impairment due to disrupted sleep or biological rhythms.Our findings show that a set of eye‐movement measures can be used to provide sensitive and reliable indicators of such mild neural impairments. AbstractSleep loss and circadian misalignment have long been known to impair human cognitive and motor performance with significant societal and health consequences. It is well known that human reaction time to a visual cue is impaired following sleep loss and circadian misalignment, but it has remained unclear how more complex visuomotor control behaviour is altered under these conditions. In this study, we measured 14 parameters of the voluntary ocular tracking response of 12 human participants (six females) to systematically examine the effects of sleep loss and circadian misalignment using a constant routine 24‐h acute sleep‐deprivation paradigm. The combination of state‐of‐the‐art oculometric and sleep‐research methodologies allowed us to document, for the first time, large changes in many components of pursuit, saccades and visual motion processing as a function of time awake and circadian phase. Further, we observed a pattern of impairment across our set of oculometric measures that is qualitatively different from that observed previously with other mild neural impairments. We conclude that dynamic vision and visuomotor control exhibit a distinct pattern of impairment linked with time awake and circadian phase. Therefore, a sufficiently broad set of oculometric measures could provide a sensitive and specific behavioural biomarker of acute sleep loss and circadian misalignment. We foresee potential applications of such oculometric biomarkers assisting in the assessment of readiness‐to‐perform higher risk tasks and in the characterization of sub‐clinical neural impairment in the face of a multiplicity of potential risk factors, including disrupted sleep and circadian rhythms.

show abstract

Section: Relationship To Prior Literaturementioning

confidence: 99%

Distinct pattern of oculomotor impairment associated with acute sleep loss and circadian misalignment

Stone

Tyson

Cravalho

et al. 2019

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Of note, sleep-deprived subjects in driving simulators have reduced peripheral attention (Jackson et al, 2008) and reduced ability to process peripheral signals (Rogé, Pébayle, El Hannachi, & Muzet, 2003). Gaze orientation, which reflects attention, is also affected by sleep deprivation, being less synchronised and slower (Tong et al, 2016). This is important because selective attention gives us the ability to focus on a particular part of the visual surround.…”

Section: Discussionmentioning

confidence: 99%

Acute sleep loss induces signs of visual discomfort in young men

Dyakova

Rångtell

Tan

et al. 2019

Journal of Sleep Research

View full text Add to dashboard Cite

Acute sleep loss influences visual processes in humans, such as recognizing facial emotions. However, to the best of our knowledge, no study till date has examined whether acute sleep loss alters visual comfort when looking at images. One image statistic that can be used to investigate the level of visual comfort experienced under visual encoding is the slope of the amplitude spectrum, also referred to as the slope constant. The slope constant describes the spatial distribution of pixel intensities and deviations from the natural slope constant can induce visual discomfort. In the present counterbalanced crossover design study, 11 young men with normal or corrected‐to‐normal vision participated in two experimental conditions: one night of sleep loss and one night of sleep. In the morning after each intervention, subjects performed a computerized psychophysics task. Specifically, they were required to adjust the slope constant of images depicting natural landscapes and close‐ups with a randomly chosen initial slope constant until they perceived each image as most natural looking. Subjects also rated the pleasantness of each selected image. Our analysis showed that following sleep loss, higher slope constants were perceived as most natural looking when viewing images of natural landscapes. Images with a higher slope constant are generally perceived as blurrier. The selected images were also rated as less pleasant after sleep loss. No such differences between the experimental conditions were noted for images of close‐ups. The results suggest that sleep loss induces signs of visual discomfort in young men. Possible implications of these findings are discussed.

show abstract

“…The oculomotor features, calculated from the eye tracking data, were aimed at characterizing visual-motor processing ( 33 ), motor control ( 34 ), and cognitive function ( 35 ). To evaluate visual-motor processing, metrics, such as reaction time of saccades in response to step changes in target position, velocity gains of smooth pursuit tracking, and the number of catch-up saccades that occurred during smooth pursuit were computed.…”

Section: Methodsmentioning

confidence: 99%

Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes

et al. 2021

Self Cite

View full text Add to dashboard Cite

There is mounting evidence linking the cumulative effects of repetitive head impacts to neuro-degenerative conditions. Robust clinical assessment tools to identify mild traumatic brain injuries are needed to assist with timely diagnosis for return-to-field decisions and appropriately guide rehabilitation. The focus of the present study is to investigate the potential for oculomotor features to complement existing diagnostic tools, such as measurements of Optic Nerve Sheath Diameter (ONSD) and Immediate Post-concussion Assessment and Cognitive Testing (ImPACT). Thirty-one high school American football and soccer athletes were tracked through the course of a sports season. Given the high risk of repetitive head impacts associated with both soccer and football, our hypotheses were that (1) ONSD and ImPACT scores would worsen through the season and (2) oculomotor features would effectively capture both neurophysiological changes reflected by ONSD and neuro-functional status assessed via ImPACT. Oculomotor features were used as input to Linear Mixed-Effects Regression models to predict ONSD and ImPACT scores as outcomes. Prediction accuracy was evaluated to identify explicit relationships between eye movements, ONSD, and ImPACT scores. Significant Pearson correlations were observed between predicted and actual outcomes for ONSD (Raw = 0.70; Normalized = 0.45) and for ImPACT (Raw = 0.86; Normalized = 0.71), demonstrating the capability of oculomotor features to capture neurological changes detected by both ONSD and ImPACT. The most predictive features were found to relate to motor control and visual-motor processing. In future work, oculomotor models, linking neural structures to oculomotor function, can be built to gain extended mechanistic insights into neurophysiological changes observed through seasons of participation in contact sports.

show abstract

Degradation of Binocular Coordination during Sleep Deprivation

Cited by 10 publications

References 30 publications

Distinct pattern of oculomotor impairment associated with acute sleep loss and circadian misalignment

Distinct pattern of oculomotor impairment associated with acute sleep loss and circadian misalignment

Acute sleep loss induces signs of visual discomfort in young men

Using Oculomotor Features to Predict Changes in Optic Nerve Sheath Diameter and ImPACT Scores From Contact-Sport Athletes

Contact Info

Product

Resources

About