Degenerative Collagenous Plaques of the Hands

Collagenous and elastotic marginal plaques of the hands

“…The ulnar side of the hand and other sites on the fingers are rarely involved. These linear plaques may show white or yellow colouration and sometimes show telangiectasia 1–9 . These typical clinical findings were exemplified in the present case.…”

“…No masses of basophilic elastotic material with calcification were identified; instead, the calcification was generally on an eosinophilic background that appeared to represent a thick collagen bundle in cross‐section. The papular outline demonstrated histologically in early cases in previous reports 1,7 was not documented in our biopsy. Epidermal changes in CEMPH are usually less striking and have been reported to variably include hyperkeratosis, acanthosis and atrophy 7,8 .…”

“…These collagen bundles, which are often surrounded by retraction artefact, 1 were prominent in our case. Between the collagen bundles, there is amorphous basophilic material and elastic fibres 1–9 . These basophilic components are often more prominent superficially, 7 as demonstrated in the present case.…”

Keratoelastoidosis Marginalis of the Hands: A Distinct Form of Palmoplantar Keratoderma

“…Histological findings of KEMH may include acanthosis of the epidermis with overlying orthohyperkeratosis, which can result from repeated episodes of hypoxia resulting from papillary dermal capillary occlusion during periods of pressure, combined with compression from elastotic material that accumulates in the dermis [ 3 ]. In the dermis, there are thick, haphazardly arranged collagen bundles, sometimes perpendicular to the epidermis, often surrounded by retraction artifacts and elastic fragmentation [ 2 - 7 , 11 - 15 ], as is also evident in our case. Additionally, some authors described the presence of basophilic elastotic masses that are often calcified [ 7 ], a feature not encountered in our case.…”

Collagenous and elastotic marginal plaques of the hand: A potential clue to the diagnosis of alkaptonuria

“…Compared to CEMPH in AKU, the isolated (acquired) variant of CEMPH shows overlapping clinicopathologic features: both are marginal keratodermas with haphazardly arranged, thick hyaline collagen bundles with a presentation in middle‐age to elderly adults . Previously only described in acquired CEMPH, elastotic fibers, elastorrhexis, and mucin deposition may also be seen in AKU‐related disease as reported here.…”