Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

Anjuère, Fabienne; Martı́n, Pilar; Ferrero, Isabel; Fraga, Marta López; Hoyo, Gloria Martı́nez del; Wright, Natalia; Ardavı́n, Carlos

doi:10.1182/blood.v93.2.590.402k11_590_598

Cited by 97 publications

(103 citation statements)

References 26 publications

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“…Increased CD8a and DEC205 expression on CD11c + CD11b À cells indicated that the majority of the remaining CD11c + cells present within the brain were similar phenotypically to lymphoid derived DC (CD11c + , CD11b À , CD8a + ) ( Fig. 1B) (Anjuere et al, 1999;Henri et al, 2001). Although the Fig.…”

Section: Resultsmentioning

confidence: 95%

“…CD11c + CD11b + cells isolated from the CNS of either CCL3 +/+ or CCL3 À/À mice expressed little to no CD8a or DEC205 suggesting a phenotype similar to myeloid derived DC (CD11c + , CD11b + , CD8a À , DEC205 À ) ( Fig. 1B) (Anjuere et al, 1999;Henri et al, 2001). Increased CD8a and DEC205 expression on CD11c + CD11b À cells indicated that the majority of the remaining CD11c + cells present within the brain were similar phenotypically to lymphoid derived DC (CD11c + , CD11b À , CD8a + ) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

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The CC chemokine ligand 3 regulates CD11c+CD11b+CD8α− dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation

Trifilo

Lane

2004

Virology

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The role of CC chemokine ligand 3 (CCL3) in activation of dendritic cells (DCs) following mouse hepatitis virus (MHV) infection of the central nervous system (CNS) was examined. The results indicate that CCL3 participates in an effective host response to MHV infection by contributing to CD11c+CD11b+CD8alpha- DC maturation, activation, and migration to cervical lymph nodes (CLN). Diminished CD8alpha- DC activation correlated with reduced IFN-gamma expression by virus-specific T cells accompanied by increased IL-10 production suggesting that CCL3 contributes to an effective host response to viral infection by enhancing the T cell activation potential of DC.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

The CC chemokine ligand 3 regulates CD11c+CD11b+CD8α− dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation

Trifilo

Lane

2004

Virology

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“…[13][14][15][16] The phenotype of DC recovered from the main conducting airways (AMDC) compares well with that of DC from the peripheral lung (LTDC). 13 Similarly, RTDC share some phenotypic traits with DC from other tissues such as the skin, 17 kidney, 18 liver 19 and gut, 20,21 particularly low expression of CD8a and high expression of CD205. However, such comparisons do more to enforce the notion that substantial heterogeneity exists among tissue DC populations.…”

Section: The Phenotype Of Mouse Rtdcmentioning

confidence: 99%

Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens

Wikström

Stumbles

2007

Immunol Cell Biol

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It is widely accepted that tissue dendritic cells (DC) function as immune sentinels by alerting T cells to foreign antigen after delivering and presenting it in the draining lymph nodes. Over the last two decades, studies in animal models, particularly rodents, have demonstrated that respiratory tract DC are crucial for the adaptive immune response to inhaled antigen. Indeed, the fate of inhaled antigen is inextricably linked to the function of respiratory tract DC. In this review, we will discuss the characteristics of respiratory tract DC from mice and recent data that may help to explain their role in the fate of inhaled antigen. Keywords: airway; antigen; dendritic cell; lung; mouseThe airways and lungs are exposed to a multitude of infectious and non-infectious agents on a daily basis, and the airway epithelium employs a variety of barriers to resist and remove the majority of these agents. 1-3 For those agents that are able to evade these barriers, there is a second line of defence comprising cells of the innate and adaptive immune systems positioned throughout the respiratory tree. These cells are positioned above, below and within the epithelium, and their activities are carefully regulated in order to protect the integrity of the airways and lungs. The innate response is largely governed by macrophages, 4,5 whereas dendritic cells (DC) orchestrate the adaptive immune response. 6,7 Over the last two decades, a growing awareness of the importance of DC to adaptive immunity has focused attention on respiratory tract DC (RTDC) as important regulators of the local immune response to airborne pathogens, antigens and allergens. In this review, we will consider the characteristics of RTDC, paying particular attention to studies performed in mice, and discuss their role in the fate of inhaled antigens. THE PHENOTYPE OF MOUSE RTDCRTDC are present in the airways and lung parenchyma of mice, rats and humans. [8][9][10] In the airways, RTDC form an extensive network throughout the epithelium, 9 where their MHC class II-rich dendrites snake in between epithelial cells (e.g., see Figure 1). The number of RTDC decreases with the size of the airways 9 then increases again in the lung parenchyma, where they are literally squeezed in between the alveoli. 11,12 For the purposes of this review, RTDC located in the airways will be referred to as airway mucosal DC (AMDC) and RTDC located in the lung parenchyma will be referred to as lung tissue DC (LTDC).Mouse RTDC express high levels of MHC class II and CD11c that can be discerned from other immune cell types such as B cells and macrophages using flow cytometry (Figure 2). RTDC comprise approximately 1% of peripheral lung parenchyma and 2% of the main conducting airways of BALB/c mice. 13 A survey of a variety of surface molecules reveals RTDC are almost uniformly CD8a À/low and CD205 + , whereas CD40, CD80 and CD86 are generally expressed at low levels. [13][14][15][16] The phenotype of DC recovered from the main conducting airways (AMDC) compares well with that of DC from ...

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“…Most knowledge about human cDCs has been obtained from monocyte-derived DCs, but DCs in human tissues, particularly spleen DCs, have not been extensively characterized [8,9]. Buckley et al [10] showed that macrophages and DCs are located in the same splenic anatomical compartments and share monocyte-macrophage markers, suggesting that both cell types are related and possibly derived from a common precursor [10].…”

Section: Introductionmentioning

confidence: 99%

Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes

Velásquez‐Lopera

Correa

García³

2008

Clinical and Experimental Immunology

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Definition of Dendritic Cell Subpopulations Present in the Spleen, Peyer’s Patches, Lymph Nodes, and Skin of the Mouse

Cited by 97 publications

References 26 publications

The CC chemokine ligand 3 regulates CD11c+CD11b+CD8α− dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation

The CC chemokine ligand 3 regulates CD11c+CD11b+CD8α− dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation

Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens

Human spleen contains different subsets of dendritic cells and regulatory T lymphocytes

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