Defining the next generation of severe malaria treatment: a target product profile
Jane Achan,
Aïssata Barry,
Didier Leroy
et al.
Abstract:Background
Severe malaria is a life-threatening infection, particularly affecting children under the age of 5 years in Africa. Current treatment with parenteral artemisinin derivatives is highly efficacious. However, artemisinin partial resistance is widespread in Southeast Asia, resulting in delayed parasite clearance after therapy, and has emerged independently in South America, Oceania, and Africa. Hence, new treatments for severe malaria are needed, and it is prudent to define their charact… Show more
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