Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort

Bijlsma, Astrid Y.; Meskers, Carel G.M.; Ling, Carolina H. Y.; Narici, Marco V.; Kurrle, Sue; Cameron, Ian D.; Westendorp, Rudi G.J.; Maier, Andrea B.

doi:10.1007/s11357-012-9384-z

Cited by 226 publications

(209 citation statements)

References 48 publications

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“…17,30 The prevalence of sarcopenia varies depending on the methods used to define the diagnosis. Bijlsma et al 31 used seven different diagnostic criteria for sarcopenia, based on measurements of muscle mass (BIA or DXA) and HGS. The authors noted that the criteria based on a low HGS and a low quantity of SMM differed greatly from the criteria based on appendicular lean mass (ALM).…”

Section: Discussionmentioning

confidence: 99%

Análise de métodos para detectar sarcopenia em idosas independentes da comunidade

Paula

Wamser

Gomes

et al. 2016

Rev. bras. geriatr. gerontol.

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Introduction: Aging imposes changes in the body composition of individuals. One of the most striking changes during this period is the progressive loss of mass, strength and muscle function, known as sarcopenia. Objectives: To evaluate the presence of sarcopenia in healthy elderly women living in the community through a combination of different methods to assess muscle mass (MM) and physical performance, as well as analyzing whether there is correlation between the different methods of defining sarcopenia. Methods: A cross-sectional study was performed of 37 older adults of the Universidade Aberta da Maturidade (Open University for Mature Persons). The parameters used to assess MM were calf circumference (CC) and skeletal muscle mass (SMM) through bioelectrical impedance (BIA) and the skeletal muscle index (SMI) Handgrip strength (HS) using a manual dynamometer, gait speed (GS) over 10m and the timed up and go (TUG) test for functional mobility were used to measure physical performance. To compare the sarcopenia diagnostic methods four different combinations were employed: C1= SMI+HS+GS; C2= SMI+HS+TUG; C3= CC+HS+GS and C4= CC+HS+TUG, according to European consensus proposals. To verify the differences between the methods the Kruskal-Wallis test and Multiple Comparisons for Unpaired Data were applied, and the weighted Kappa coefficient was used to assess the degree of agreement. Results: The C1 and C2 combinations identified pre-sarcopenia, sarcopenia and severe sarcopenia. A close correlation between C1 and C2 was found (0.92), while C3 and C4 did not identify the presence of sarcopenia in the elderly women. Conclusion: CC used to evaluate MM was not precise in the detection of sarcopenia in overweight elderly women. However, there was a strong agreement between the two combinations using SMI and GS or TUG, suggesting that both can be effectively applied in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Análise de métodos para detectar sarcopenia em idosas independentes da comunidade

Paula

Wamser

Gomes

et al. 2016

Rev. bras. geriatr. gerontol.

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“…During the last two decades, several diagnostic criteria for sarcopenia have been proposed, which can be categorized into measures of relative muscle mass (defined as total or appendicular lean mass (ALM) as percentage of body mass), absolute muscle mass (defined as ALM corrected for height (ALM/height squared) or total lean mass), muscle strength, walking speed, or a combination of criteria (Cruz-Jentoft et al 2010;Fielding et al 2011). Previously, we have shown that the prevalence of sarcopenia is highly dependent on the diagnostic criteria (Bijlsma et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic criteria for sarcopenia and physical performance

Bijlsma

Meskers

Eshof

et al. 2013

AGE

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Relative and absolute muscle mass and muscle strength are used as diagnostic criteria for sarcopenia. We aimed to assess which diagnostic criteria are most associated with physical performance in 180 young (18-30 years) and 281 healthy old participants (69-81 years) of the European study MYOAGE. Diagnostic criteria included relative muscle mass (total or appendicular lean mass (ALM) as percentage of body mass), absolute muscle mass (ALM/height squared and total lean mass), knee extension torque, and handgrip strength. Physical performance comprised walking speed, Timed Up and Go test (TUG), and in a subgroup physical fitness. Diagnostic criteria for sarcopenia and physical performance were standardized, and the associations were analyzed using linear regression models stratified by age category, with adjustments for age, gender, and country. In old participants, relative muscle mass was associated with faster walking speed, faster TUG, and higher physical fitness (all p<0.001). Absolute muscle mass was not associated with physical AGE (2014) performance. Knee extension torque and handgrip strength were associated with faster walking speed (both p≤0.003). Knee extension torque was associated with TUG (p=0.001). Knee extension torque and handgrip strength were not associated with physical fitness. In young participants, there were no significant associations between diagnostic criteria for sarcopenia and physical performance, except for a positive association between relative muscle mass and physical fitness (p<0.001). Relative muscle mass, defined as lean mass or ALM percentage, was most associated with physical performance. Absolute muscle mass including ALM/height squared was not associated with physical performance. This should be accounted for when defining sarcopenia.

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“…Bijlsma et al 18 applied six different formulas to define low lean body mass. Comparatively, low lean mass among men aged 60-69 years varied from 0 to 31% and for those older than 70 years from 0 to 45%.…”

Section: Discussionmentioning

confidence: 99%

Indicadores antropométricos como instrumento de triagem para quedas em idosos

Freitas

Amorim

Dip

et al. 2016

Rev. Bras. Cineantropom. Desempenho Hum.

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-Anthropometric indicators enable professionals for predicting risk of falls in the elderly; however, there is a gap in literature on reference values. This study analyzes anthropometric indicators such as screening tests for falls in the elderly. Cross-sectional population-based systematic sampling was conducted through a household survey and body composition assessment. Anthropometric measurements were performed using portable electronic scale and stadiometer. Bioimpedance device was used to measure body mass index, body fat and lean body mass. Falls were evaluated in the 12 months preceding the interview as a dependent variable. Discriminatory analysis was performed for falls through the ROC curve, sensitivity, specificity, positive and negative predictive values. Overall, 275 older adults participated in this study, whose prevalence of falls was 23.6%. The average body mass index was 27.8kg/cm 2 and 52.1% of individuals were overweight. Among older men, height (ROC=0.68; 95%CI 0.54-0.78) and lean body mass (ROC=0.63, 95%CI 0.58-0.76) were associated to the occurrence of falls. When considering cutoff of 52.2kg and 166cm, sensitivity was obtained in 75% and high negative predictive values (88.1% and 89.1% respectively). For women, lean body mass (ROC=0.61, 95%CI 0.30-0.49) and body mass (ROC=0.60, 95%CI 0.53-0.72) were relevant from the optimal cutoff point of 28.9% and 57.2kg/m 2 . Lean body mass was more sensitive (63.2%) and body mass little more specific (64.3%), both with high negative predictive values (82.0% and 83.0%). The indicators used were able to discriminate older adults who have suffered from falls.Key words: Anthropometry; Obesity; Older adults; ROC Curve; Sarcopenia. ROC=0,68; IC95%=0,78) e massa corporal magra (ROC=0,63; IC95%=0,76) (88,1% e 89,1% respectivamente). Para as mulheres, a massa corporal magra (ROC=0,61; IC95%=0,49) e a massa corporal (ROC=0,60; IC95%=0,72) Resumo -Indicadores antropométricos instrumentalizam profissionais para predizer risco de quedas em idosos, entretanto, há lacunas de evidências na literatura sobre valores de referência. O objetivo foi analisar os indicadores antropométricos como testes de rastreio para quedas em idosos. Estudo com delineamento transversal de base populacional

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Defining sarcopenia: the impact of different diagnostic criteria on the prevalence of sarcopenia in a large middle aged cohort

Cited by 226 publications

References 48 publications

Análise de métodos para detectar sarcopenia em idosas independentes da comunidade

Análise de métodos para detectar sarcopenia em idosas independentes da comunidade

Diagnostic criteria for sarcopenia and physical performance

Indicadores antropométricos como instrumento de triagem para quedas em idosos

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