volume 27, issue 1, P89-98 2011
DOI: 10.3233/jad-2011-110479
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Jun-xiang Yin, Gregory H. Turner, Hao-jie Lin, Stephen W. Coons, Jiong Shi

Abstract: Apolipoprotein E ε4 (ApoE4) has been implicated as a potential genetic risk factor for dementia. In this study, we investigate the effect of ApoE4 on learning and memory, changes in brain volume and neuroinflammatory responses in brain of ApoE4 transgenic mice. Four groups of male mice with ApoE4 and age-matched wild type (WT) (6-, 12-, 18- and 24-month) were studied. Spatial learning and retaining of mice was examined in the Morris Water Maze (MWM). Changes in brain volume (including the whole brain, hippocam…

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