2020
DOI: 10.3390/jpm10020032
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Abstract: Alzheimer’s disease (AD) is diagnosed using neuropsychological testing, supported by amyloid and tau biomarkers and neuroimaging abnormalities. The cause of neuropsychological changes is not clear since they do not correlate with biomarkers. This study investigated if changes in cellular metabolism in AD correlate with neuropsychological changes. Fibroblasts were taken from 10 AD patients and 10 controls. Metabolic assessment included measuring total cellular ATP, extracellular lactate, mitochondrial membrane … Show more

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Cited by 20 publications
(34 citation statements)
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“…Consistently, enhanced SRC promotes cell survival, whereas reduced SRC may contribute to cell death (Nickens et al, 2013; Yadava and Nicholls, 2007). In AD, deficiency of SRC was shown to contribute to neuropsychological changes (Bell et al, 2020). Since mitochondrial bioenergetic function is one of the early deficits in AD (Terada et al, 2020; Yao et al, 2009), reduction of GSAP level may delay the pathogenesis of AD.…”
Section: Resultsmentioning
confidence: 99%
“…Consistently, enhanced SRC promotes cell survival, whereas reduced SRC may contribute to cell death (Nickens et al, 2013; Yadava and Nicholls, 2007). In AD, deficiency of SRC was shown to contribute to neuropsychological changes (Bell et al, 2020). Since mitochondrial bioenergetic function is one of the early deficits in AD (Terada et al, 2020; Yao et al, 2009), reduction of GSAP level may delay the pathogenesis of AD.…”
Section: Resultsmentioning
confidence: 99%
“…CHO-APP 695 cells pre-treated with 10 μM PIO and 10 μM PIO NP were observed to exhibit significantly higher reserve respiratory capacity ratios, which is the difference between maximal and basal OCRs and serves as an indicator of how well the mitochondria within cells are able to increase ATP production in response to increases in energy demand [ 45 ]. Importantly, deficits in mitochondrial reserve respiratory capacity have been found to correlate to neuropsychological changes seen in patients with early stages of sporadic AD [ 46 ]. In this study, we noticed that pre-treatment with 10 µM PIO NP elevated the reserve respiratory capacity even more than 10 µM PIO solution, which could be due to the increased cellular uptake of TPGS-coated PLGA nanoparticles [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…ATP and MMP levels have been shown to be low in some studies of both sporadic and familial AD fibroblasts [ 63 , 64 , 65 , 66 ]. However, normal and higher than control levels of ATP and MMP have also been found in AD fibroblasts [ 67 , 68 , 69 ]. Alterations in the NAD+/NADH ratio, and how this is maintained, is seen in fibroblasts from patients with sporadic AD who have high OCR and MMP compared to controls [ 68 ].…”
Section: Electron Transport Chain Disruption In Admentioning
confidence: 99%
“…The imaging of mitochondrial function using functional MRI has shown that mitochondrial dysfunction is already used to differentiate surrogate markers of normal brain mitochondrial function from the abnormalities seen in AD. A recently published study described how fibroblast MSRC may have the potential to be developed into a biomarker of AD, as deficits in MSRC correlate with changes seen in established biomarkers early in the AD disease process [ 69 ].…”
Section: Mitochondrial Dysfunction: a Future Biomarker Of Ad?mentioning
confidence: 99%