Deficits in Drinking and Vasopressin Secretion after Lesions of the Nucleus medianus

Mangiapane, Michael L.; Thrasher, T. N.; Keil, L. C.; Simpson, John B.; Ganong, William F.

doi:10.1159/000123518

Cited by 177 publications

(71 citation statements)

References 4 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the All receptors localized in this study correspond with many of the sites at which the peptide is known to exert behavioral, endocrine, or physiological actions. For example, sites involved in the drinking response to All, including the subfornical organ (58), organum vasculosum of the lamina terminalis (59), medial preoptic area (60), and median-preoptic nucleus (61), all contained moderate to high densities of angiotensin receptors. A neural pathway for angiotensin-mediated drinking has been defined by injections into subfornical organ of tritiated amino acids (62,63) or horseradish-peroxidase (64) and central lesion experiments (65).…”

Section: Discussionmentioning

confidence: 99%

Autoradiographic localization of angiotensin II receptors in rat brain.

Mendelsohn¹,

Quirion²,

Saavedra³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

442

209

View full text Add to dashboard Cite

The 125I-labeled agonist analog [1-sarcosine]-angiotensin II ([Sar']AII) bound with high specificity and affinity (Ka = 2 x 109 M-1) to a single class of receptor sites in rat brain. This ligand was used to analyze the distribution of All receptors in rat brain by in vitro autoradiography followed by computerized densitometry and color coding. A very high density of All receptors was found in the subfornical organ, paraventricular and periventricular nuclei of the hypothalamus, nucleus of the tractus solitarius, and area postrema. A high concentration of receptors was found in the suprachiasmatic nucleus of the hypothalamus, lateral olfactory tracts, nuclei of the accessory and lateral olfactory tracts, triangular septal nucleus, subthalamic nucleus, locus coeruleus, and inferior olivary nuclei. Moderate receptor concentrations were found in the organum vasculosum of the lamina terminalis, median preoptic nucleus, medial habenular nucleus, lateral septum, ventroposterior thalamic nucleus, median eminence, medial geniculate nucleus, superior colliculus, subiculum, preand parasubiculum, and spinal trigeminal tract. Low concentrations of sites were seen in caudate-putamen, nucleus accumbens, amygdala, and gray matter of the spinal cord. These studies have demonstrated that All receptors are distributed in a highly characteristic anatomical pattern in the brain. The high concentrations of All receptors at numerous physiologically relevant sites are consistent with the emerging evidence for multiple roles of All as a neuropeptide in the central nervous system.

show abstract

Section: Discussionmentioning

confidence: 99%

Autoradiographic localization of angiotensin II receptors in rat brain.

Mendelsohn¹,

Quirion²,

Saavedra³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

442

209

View full text Add to dashboard Cite

show abstract

“…Additional afferent and efferent connectivity with neurons in hypothalamic and brain stem centers provide possible circuits whereby MnPO neurons can influence several aspects of homeostasis such as hydromineral and cardiovascular regulation, salt appetite, and sleep-waking behavior (Johnson et al 1996;McKinley et al 1996;Suntsova et al 2002). Indeed major disruptions to homeostasis can be noted as a consequence of structural or chemical lesions focused on MnPO and the neighboring periventricular tissues (e.g., Bealer 2000; Cunningham et al 1991;Gardiner et al 1985Gardiner et al , 1986Mangiapane et al 1983;Yasuda et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Metabotropic Glutamate Receptors in Median Preoptic Neurons Modulate Neuronal Excitability and Glutamatergic and GABAergic Inputs From the Subfornical Organ

Kolaj

Renaud

2010

Journal of Neurophysiology

View full text Add to dashboard Cite

Kolaj M, Renaud LP. Metabotropic glutamate receptors in median preoptic neurons modulate neuronal excitability and glutamatergic and GABAergic inputs from the subfornical organ. J Neurophysiol 103: 1104-1113, 2010. First published December 16, 2009 doi:10.1152/jn.00808.2009. Cardiovascular and behavioral responses to circulating angiotensin require intact connectivity along the upper lamina terminalis joining the subfornical organ (SFO) with the median preoptic nucleus (MnPO). In the present study on MnPO neurons, we used whole cell patch-clamp recording techniques in brain slice preparations to evaluate the influence of metabotropic glutamate receptor (mGluR) agonists on modulating their intrinsic excitability and SFO-evoked glutamatergic and GABAergic postsynaptic currents. In 22/36 cells, bath application of a mGluR group I agonist (S)-3,5-dihydroxyphenylglycine (DHPG) induced a TTX-resistant inward current coupled with decrease in a membrane K ϩ conductance but also a possible increase in a nonselective cationic conductance. By contrast, 27/49 cells responded to a mGluR group II agonist (2S,2ЈR,3ЈR)-2-(2Ј,3Ј-dicarboxycyclopropyl) glycine (DCG IV) with a TTX-resistant outward current and increase in membrane conductance that reversed around Ϫ95 mV, suggesting opening of K ϩ channels. None of 19 cells responded to the mGluR group III agonist L-(ϩ)-2-amino-4-phosphonobutyric acid (L-AP4). Agonists for all mGluR groups suppressed SFO-evoked excitatory postsynaptic currents and significantly increased paired-pulse ratios, implying a presynaptic mechanism. Only the mGluR group II agonist significantly reduced SFO-evoked inhibitory postsynaptic currents and caused an increase in paired-pulse ratios. These results suggest a complexity of pre-and postsynaptic mGluRs are available to modulate rapid neurotransmission along the upper lamina terminalis from SFO to MnPO.

show abstract

“…Lesions of the MnPO disrupt the drinking behavior in response to hyperosmolality, ANG II and hypovolemia (Mangiapane et al, 1983;Cunningham et al, 1991;Cunningham et al, 1992), attenuate vasopressin secretion during increase plasma osmolality and ANG II levels (Mangiapane et al, 1983;, and blunt centrally mediated pressor responses to hypertonic saline and ANG II (O'Neill and Brody, 1987;Yasuda et al, 2000). Each of the aforementioned stimuli increase Fos immunoreactivity, a marker of synaptic activation, in MnPO neurons (Oldfield et al, 1994;Larsen and Mikkelsen, 1995;Potts et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Vagal afferent input alters the discharge of osmotic and ANG II-responsive median preoptic neurons projecting to the hypothalamic paraventricular nucleus

Stocker

Toney

2007

Brain Research

View full text Add to dashboard Cite

The goal of the present study was to determine the effect of activating vagal afferent fibers on the discharge of median preoptic (MnPO) neurons responsive to peripheral angiotensin II (ANG II) and osmotic inputs. Vagal afferents were activated by electrical stimulation of the proximal end of the transected cervical vagus nerve (3 pulses, 100 Hz, 1 ms, 100-500 μA). Of 21 MnPO neurons, 19 were antidromically activated from the hypothalamic paraventricular nucleus (PVH) (latency: 10.3 ±1.3 ms, threshold: 278±25 μA). MnPO-PVH cells had an average spontaneous discharge of 2.1±0.4 Hz. Injection of ANG II (150 ng) and/or hypertonic NaCl (1.5 Osm/L, 100 μl) through the internal carotid artery significantly (P<0.01) increased the firing rate of most 84%). Vagus nerve stimulation significantly (P<0.01) decreased discharge (−73±9%) in 10 of 16 (63%) neurons with an average onset latency of 108±19 ms. Among the remaining 6 MnPO-PVH neurons vagal activation either increased discharge (177±100%) with a latency of 115±15 ms (n=2) or had no effect (n=4). Pharmacological activation of chemosensitive vagal afferents with phenyl biguanide produced an increase (n=3), decrease (n=2), or no change (n=6) in discharge. These observations indicate that a significant proportion of ANG II-and/or osmo-sensitive MnPO neurons receive convergent vagal input. Although the sensory modalities transmitted by the vagal afferents to MnPO-PVH neurons are not presently known, the presence of inhibitory and excitatory vagalevoked responses indicates that synaptic processing by these cells integrates humoral and visceral information to subserve potentially important cardiovascular and body fluid homeostatic functions.

show abstract

Deficits in Drinking and Vasopressin Secretion after Lesions of the Nucleus medianus

Cited by 177 publications

References 4 publications

Autoradiographic localization of angiotensin II receptors in rat brain.

Autoradiographic localization of angiotensin II receptors in rat brain.

Metabotropic Glutamate Receptors in Median Preoptic Neurons Modulate Neuronal Excitability and Glutamatergic and GABAergic Inputs From the Subfornical Organ

Vagal afferent input alters the discharge of osmotic and ANG II-responsive median preoptic neurons projecting to the hypothalamic paraventricular nucleus

Contact Info

Product

Resources

About