volume 8, issue 5, P977-985 2016
DOI: 10.18632/aging.100957
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Guibin Xu, Fei Yue, Hai Huang, Yongzhong He, Xun Li, Haibo Zhao, Zhengming Su, Xianhan Jiang, Wenjiao Li, Jing Zou, Qi Chen, Leyuan Liu

Abstract: Excessive deposition of extracellular matrix proteins in renal tissues causes renal fibrosis and renal function failure. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and dysfunctional organelles. MAP1S is an autophagy activator and promotes the biogenesis and degradation of autophagosomes. Previously, we reported that MAP1S suppresses hepatocellular carcinogenesis in a mouse model and predicts a better prognosis in patients suffering from clear cell renal…

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