Defect modified zinc oxide with augmenting sonodynamic reactive oxygen species generation

Liu, Yang; Wang, Ying; Zhen, Wenyao; Wang, Yinghui; Zhang, Songtao; Zhao, Ying; Song, Shuyan; Wu, Zhijian; Zhang, Hongjie

doi:10.1016/j.biomaterials.2020.120075

Cited by 149 publications

(113 citation statements)

References 32 publications

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“…This observation further indicated that 1 O 2 can indeed be produced under 808 nm laser irradiation, and the obtained results are identical to those obtained by the ESR measurements. It is known that the preparation of metallic oxides at high temperature can lead to their structure defects, [ 25 ] and these defects are highly related to the 1 O 2 production under light irradiation. [ 26 ] RuO 2 NPs in RuO 2 @OVA NAs were primarily prepared at 300 °C, and then, they were complexed with OVA to produce RuO 2 @OVA NAs.…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Figure S8 of the Supporting Information, both RuO 2 NPs and RuO 2 @OVA NAs displayed an obvious signal at the g-value of 2.003, confirming the presence of defects in RuO 2 NPs and RuO 2 @OVA NAs. Furthermore, referring to the reported literature of defective metallic oxides for the 1 O 2 production under light irradiation, [25][26][27] the possible mechanism of 1 O 2 photoinduced by RuO 2 NPs in RuO 2 @OVA NAs was proposed, where O 2 can be sensitized to 1 O 2 by defects via energy transfer under 808 nm laser irradiation. Moreover, the literature has already reported that the rutile structure of RuO 2 has an appropriate affinity for O 2 .…”

Section: Enzyme-like Photodynamic and Photothermal Propertiesmentioning

confidence: 99%

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Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth

Huang

Ding

Jiang

et al. 2020

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Photoimmunotherapy (PIT) has shown enormous potential in not only eliminating primary tumors, but also inhibiting abscopal tumor growth. However, the efficacy of PIT is greatly limited by tumor hypoxia, which causes the attenuation of phototherapeutic efficacy and is a feature of the immunosuppressive tumor microenvironment (TME). In this study, one type of brand‐new artificial metalloprotein nanoanalogues is developed via reasonable integration of a “phototherapy‐enzymatic” RuO2 and a model antigen, ovalbumin (OVA) for enhanced PIT of cancers, namely, RuO2‐hybridized OVA nanoanalogues (RuO2@OVA NAs). The RuO2@OVA NAs exhibit remarkable photothermal/photodynamic capabilities under the near‐infrared light irradiation. More importantly, the photoacoustic imaging and immunofluorescence staining confirm that RuO2@OVA NAs can remarkably alleviate hypoxia via in situ catalysis of hydrogen peroxide overexpressed in the TME to produce oxygen (O2). This ushers a prospect of concurrently enhancing photodynamic therapy and reversing the immunosuppressive TME. Also, OVA, as a supplement to the immune stimulation induced by phototherapy, can activate immune responses. Finally, further combination with the cytotoxic T‐lymphocyte‐associated protein 4 checkpoint blockade is reported to effectively eliminate the primary tumor and inhibit distant tumor growth via the abscopal effect of antitumor immune responses, prolonging the survival.

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Section: Resultsmentioning

confidence: 99%

Section: Enzyme-like Photodynamic and Photothermal Propertiesmentioning

confidence: 99%

Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth

Huang

Ding

Jiang

et al. 2020

Small

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Section: Sonodynamic Therapy Combined With Phototherapymentioning

confidence: 99%

“…first developed the gadolinium doped zinc oxide (D‐ZnO x :Gd) semiconductor sonosensitizer for synergistically enhanced NIR‐II window PTT and SDT cancer treatment (Figure 9C). [ 81 ] They doped Gd into a ZnO semiconductor to create an oxygen defect and enhance the SDT effect and further endow it with a robust PTT performance. Respectively, the US‐ and 1064 nm laser‐triggered synergistic PTT and SDT was demonstrated to exert a high efficiency of inhibition of proliferation of the breast cancer tumor.…”

Section: Sonodynamic Therapy Combined With Other Treatmentsmentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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“…Additionally, the hydrophobic nature of most of these small molecules makes them easily aggregate in the physiological environment, thereby reducing their bioavailability and ROS generation efficiency [7] . To solve the unmet needs the past years have seen a focus on the synthesis of biocompatible inorganic nanomaterial‐based sonosensitizers such as titanium dioxide (TiO 2 ), zinc oxide (ZnO) nanomaterials, and their nanocomposites [11–13] . These studies have substantially increased the chemical stability, biocompatibility, and desirable tumor accumulation for SDT.…”

Section: Introductionmentioning

confidence: 99%

Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

Chen

LIU

et al. 2021

Angewandte Chemie

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Ultrasound (US)‐mediated sonodynamic therapy (SDT) has emerged as a superior modality for cancer treatment owing to the non‐invasiveness and high tissue‐penetrating depth. However, developing biocompatible nanomaterial‐based sonosensitizers with efficient SDT capability remains challenging. Here, we employed a liquid‐phase exfoliation strategy to obtain a new type of two‐dimensional (2D) stanene‐based nanosheets (SnNSs) with a band gap of 2.3 eV, which is narrower than those of the most extensively studied nano‐sonosensitizers, allowing a more efficient US‐triggered separation of electron (e−)‐hole (h+) pairs for reactive oxygen species (ROS) generation. In addition, we discovered that such SnNSs could also serve as robust near‐infrared (NIR)‐mediated photothermal therapy (PTT) agents owing to their efficient photothermal conversion, and serve as nanocarriers for anticancer drug delivery owing to the inherent 2D layered structure. This study not only presents general nanoplatforms for SDT‐enhanced combination cancer therapy, but also highlights the utility of 2D SnNSs to the field of nanomedicine.

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Defect modified zinc oxide with augmenting sonodynamic reactive oxygen species generation

Cited by 149 publications

References 32 publications

Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth

Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Stanene‐Based Nanosheets for β‐Elemene Delivery and Ultrasound‐Mediated Combination Cancer Therapy

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