Abstract:The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate
immune system known to act in the first line of defence against microorganisms,
including viruses such as human papillomavirus (HPV). In this study, five functional
polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and
c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding
for hBD-1 were analysed to investigate the possible involvement of these genetic
variants in susceptibility to HPV infection and in the de… Show more
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