Deep-sea natural products

Skropeta, Danielle

doi:10.1039/b808743a

Cited by 170 publications

(150 citation statements)

References 303 publications

(466 reference statements)

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“…2В), которое с 2007 г. одобрено в Европе для лечения распространённой саркомы мягких тканей [19]. Полезные организмы могут существовать в экстремальной внешней среде, например, на большой морской глубине [20], в термальных источниках или в солевых озёрах. Примером может быть идентификация галодурацина (haloduracin) -двухкомпонентного лантибиотика (пептидный антибиотик, содержащий лантионин*) из Bacillus halodurans, растущего при экстремальном рН > 9,0 [21].…”

Section: примечания переводчика * Hit Rate -принятый в бизнесе показunclassified

Drug discovery and natural products: end of era or an endless frontier?

2011

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Drug discovery and natural products: end of era or an endless frontier? Перевод печатается с разрешения авторов и журнала Science)Исторически большинство новых лекарств разрабатывалось из природных продуктов (или их вторичных метаболитов) и из полученных из них соединений. В течение последних 15 лет исследования фармацевтической индустрии в области природных веществ заметно снизились, и одной из причин этого можно считать особое внимание к высоко производительному скринингу библиотек синтетических соединений. В настоящее время отмечается существенное снижение количества новых одобренных соответствующими инстанциями лекарств, а также потеря патентной защиты у ряда важных препаратов. Однако не иссякающие биологические источники, методы быстрого скрининга, процедуры роботизированного выделения со структурным анализом, метаболическое конструирование и синтетическая биология открывают перспективные технологические возможности для создания лекарств на основе новых природных соединений. Достижения в быстром генетическом секвенировании, в сочетании с комбинированным использованием биосинтетических путей, могут обеспечить обширный ресурс для создания новых фармакологических агентов в будущем.Ключевые слова: новые лекарства, природные соединения, библиотеки синтетических соединений, скрининг биологической активности, генетическое секвенирование, синтетическая биология.Около 200 лет назад 21-летний фармацевт Фридрих Сертюмер выделил первое биологически активное соединение из растения: морфин из опиума, вырабатываемого семенами мака, Papaver somniferum [1]. С этого момента началась эра получения из растений лекарств, которые после выделения и изучения свойств вводили в определённых дозах, не зависимых от источника или возраста материала. После Второй Мировой Войны, в связи с открытием пенициллина, фармацевтические исследования расширились, включив массивный скрининг микроорганизмов для поиска новых антибиотиков. К 1990 г. около 80% лекарств были или природными веществами, или их аналогами. Антибиотики (например, пенициллин, тетрациклин, эритромицин), антипаразитарные лекарства (авермектин), антималярийные (хинин, артемизинин), контролирующие уровень липидов агенты (ловастин и его аналоги), иммуно-супрессанты для трансплантации органов (например, циклоспорин, рапамицины), противораковые 148 * -адресат для переписки

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Section: примечания переводчика * Hit Rate -принятый в бизнесе показunclassified

Drug discovery and natural products: end of era or an endless frontier?

2011

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“…The deep ocean is the source of a number of novel natural products isolated from the highly diverse and species-rich deep-sea faunal communities (Skropeta, 2008), in particular from those found at hydrothermal vents (Thornburg et al, 2010;Martins et al 2013). As of 2008, 78 natural products have been isolated from as many as 19 classes and from all Domains of life (Skropeta, 2008). These chemicals show potential for having pharmaceutical properties and applications, including antibiotics (Liu et al, 2013) and anticancer compounds .…”

Section: Bioprospectingmentioning

confidence: 99%

Ecosystem function and services provided by the deep sea

et al. 2014

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Abstract. The deep sea is often viewed as a vast, dark, remote, and inhospitable environment, yet the deep ocean and seafloor are crucial to our lives through the services that they provide. Our understanding of how the deep sea functions remains limited, but when treated synoptically, a diversity of supporting, provisioning, regulating and cultural services becomes apparent. The biological pump transports carbon from the atmosphere into deep-ocean water masses that are separated over prolonged periods, reducing the impact of anthropogenic carbon release. Microbial oxidation of methane keeps another potent greenhouse gas out of the atmosphere while trapping carbon in authigenic carbonates. Nutrient regeneration by all faunal size classes provides the elements necessary for fueling surface productivity and fisheries, and microbial processes detoxify a diversity of compounds. Each of these processes occur on a very small scale, yet considering the vast area over which they occur they become important for the global functioning of the ocean. The deep sea also provides a wealth of resources, including fish stocks, enormous bioprospecting potential, and elements and energy reserves that are currently being extracted and will be increasingly important in the near future. Society benefits from the intrigue and mystery, the strange life forms, and the great unknown that has acted as a muse for inspiration and imagination since near the beginning of civilization. While many functions occur on the scale of microns to meters and timescales up to years, the derived services that result are only useful after centuries of integrated activity. This vast dark habitat, which covers the majority of the globe, harbors processes that directly impact humans in a variety of ways; however, the same traits that differentiate it from terrestrial or shallow marine systems also result in a greater need for integrated spatial and temporal understanding as it experiences increased use by society. In this manuscript we aim to provide a foundation for informed conservation and management of the deep sea by summarizing the important role of the deep sea in society.

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“…The author would also like to thank Danielle Skropeta for deep-sea natural products data in Fig.1 (Skropeta, 2008, Skropeta andWei, 2014). This paper is based on a presentation by the author to the 14th Deep-Sea Biology Symposium (Aveiro, 01 September 2015), the author gratefully acknowledges funding support from the University of Wollongong Global Challenges Program to attend at this conference.…”

Section: Resultsmentioning

confidence: 99%

“…The deep-sea is recognised as a significant source of genetic resources. Marine invertebrates, in particular Porifera (Martins et al, 2014, Skropeta, 2008, and microorganisms (Abida et al, 2013, Pettit, 2011, Shimmield, 2013, Sogin et al, 2006 are the largest sources of novel marine natural products described. Viruses are an attractive source of new protein discoveries (Arrieta et al, 2010, Yooseph et al, 2007.…”

Section: Lack Of Definition Of Mgr and Unclear Legal Status In Abnjmentioning

confidence: 99%

Deep-sea genetic resources: New frontiers for science and stewardship in areas beyond national jurisdiction

Harden‐Davies

2017

Deep Sea Research Part II: Topical Studies in Oceanography

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The deep-sea is a large source of marine genetic resources (MGR), which have many potential uses and are a growing area of research. Much of the deep-sea lies in areas beyond national jurisdiction (ABNJ), including 65% of the global ocean. MGR in ABNJ occupy a significant gap in the international legal framework. Access and benefit sharing of MGR is a key issue in the development of a new international legally-binding instrument under the United Nations Convention on the Law of the Sea (UNCLOS) for the conservation and sustainable use of marine biological diversity in ABNJ. This paper examines how this is relevant to deep-sea scientific research and identifies emerging challenges and opportunities. There is no internationally agreed definition of MGR, however, deep-sea genetic resources could incorporate any biological material including genes, proteins and natural products. Deep-sea scientific research is the key actor accessing MGR in ABNJ and sharing benefits such as data, samples and knowledge. UNCLOS provides the international legal framework for marine scientific research, international science cooperation, capacity building and marine technology transfer. Enhanced implementation could support access and benefit sharing of MGR in ABNJ. Deep-sea scientific researchers could play an important role in informing practical new governance solutions for access and benefit sharing of MGR that promote scientific research in ABNJ and support deep-sea stewardship. Advancing knowledge of deep-sea biodiversity in ABNJ, enhancing open-access to data and samples, standardisation and international marine science cooperation are significant potential opportunity areas. There is no internationally agreed definition of MGR, however, deep-sea genetic resources could incorporate any biological material including genes, proteins and natural products.Deep-sea scientific research is the key actor accessing MGR in ABNJ and sharing benefits such as data, samples and knowledge. UNCLOS provides the international legal framework for marine scientific research, international science cooperation, capacity building and marine technology transfer. Enhanced implementation could support access and benefit sharing of MGR in ABNJ. Deep-sea scientific researchers could play an important role in informing practical new governance solutions for access and benefit sharing of MGR that promote scientific research in ABNJ and support deep-sea stewardship. Advancing knowledge of 2 deep-sea biodiversity in ABNJ, enhancing open-access to data and samples, standardisation and international marine science cooperation are significant potential opportunity areas. 1 KEYWORDS: Law of the sea; international law; marine resources; ocean policy; marine genetic resources; areas beyond national jurisdiction; high seas; access and benefit sharing.

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Deep-sea natural products

Cited by 170 publications

References 303 publications

Drug discovery and natural products: end of era or an endless frontier?

Drug discovery and natural products: end of era or an endless frontier?

Ecosystem function and services provided by the deep sea

Deep-sea genetic resources: New frontiers for science and stewardship in areas beyond national jurisdiction

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