volume 29, issue 3, P319-328 2015
DOI: 10.3109/02688697.2014.997669
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Alexander Alamri, Ismail Ughratdar, Michael Samuel, Keyoumars Ashkan

Abstract: High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now ending its second decade as an established modality for treating Parkinson's disease (PD). Knowledge of the pathophysiology of PD and clinical applications for STN DBS is burgeoning. Despite this, the mechanism of how STN DBS works remains an enigma. Furthermore, motor symptoms have been seen as a focus for improved quality of life after STN DBS yet non-motor symptoms also play an integral role in determining treatment outcome.…

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