Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Valverde, Sébastien; Vandecasteele, Marie; Piette, Charlotte; Derousseaux, Willy; Gangarossa, Giuseppe; Arbelaiz, Asier Aristieta; Touboul, Jonathan; Degos, Bertrand; Venance, Laurent

doi:10.1038/s41467-020-16046-6

Cited by 54 publications

(55 citation statements)

References 71 publications

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“…Similarly, dyskinetic rats exhibit changes in gene expression 23 and an increased activity in about half of the neurons of the motor cortex 24 . In addition, subthalamic deep brain stimulation, which reduce PD symptoms and thus prevent the need of high L-DOPA dosage producing LID, have been proposed to act via an effect on the motor cortex 25, 26 . Likewise, cerebellar cTBS has been shown to exert a control on motor cortex plasticity 27 .…”

Section: Introductionmentioning

confidence: 99%

Cerebellar stimulations prevent Levodopa-induced dyskinesia in mice and normalize brain activity

Coutant

Frontera

Perrin

et al. 2021

Preprint

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Chronic Levodopa therapy, the gold-standard treatment of Parkinson's Disease (PD), leads to the emergence of involuntary movements, called levodopa-induced dyskinesia (LID). Cerebellar stimulations have been shown to decrease LID severity in PD patients. Here, in order to determine how cerebellar stimulations induce LID alleviation, we performed daily short trains of optogenetic stimulations of Purkinje cells (PC) in freely moving mice. We demonstrated that these stimulations are sufficient to suppress LID or even prevent their development. This symptomatic relief is accompanied by the normalization of aberrant neuronal discharge in the cerebellar nuclei, the motor cortex and the parafascicular thalamus. Inhibition of the cerebello-parafascicular pathway counteracted the beneficial effect of cerebellar stimulations. Moreover, cerebellar stimulations reversed plasticity in D1 striatal neurons and normalized the overexpression of FosB, a transcription factor causally linked to LID. These findings demonstrate LID alleviation and prevention by daily PC stimulations, which restore the function of a wide brain motor network, and may be valuable for LID treatment.

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Section: Introductionmentioning

confidence: 99%

Cerebellar stimulations prevent Levodopa-induced dyskinesia in mice and normalize brain activity

Coutant

Frontera

Perrin

et al. 2021

Preprint

Self Cite

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“…For instance, in an optogenetics application, mice were subjected to 3 ms long optostimulation pulses at 67 Hz frequency (473 nm blue laser diode) to treat Parkinson’s disease. 16 …”

Section: Resultsmentioning

confidence: 99%

“…Elsewhere, a fiber optic sensor was demonstrated for the treatment of Parkinson’s disease in mice. 16 …”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl Cellulose (CMC) Optical Fibers for Environment Sensing and Short-Range Optical Signal Transmission

Jaiswal

Hokkanen

Kapulainen

et al. 2022

ACS Appl. Mater. Interfaces

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Optical fibers are a key component in modern photonics, where conventionally used polymer materials are derived from fossil-based resources, causing heavy greenhouse emissions and raising sustainability concerns. As a potential alternative, fibers derived from cellulose-based materials offer renewability, biocompatibility, and biodegradability. In the present work, we studied the potential of carboxymethyl cellulose (CMC) to prepare optical fibers with a core-only architecture. Wet-spun CMC hydrogel filaments were cross-linked using aluminum ions to fabricate optical fibers. The transmission spectra of fibers suggest that the light transmission window for cladding-free CMC fibers was in the range of 550–1350 nm, wherein the attenuation coefficient for CMC fibers was measured to be 1.6 dB·cm –1 at 637 nm. CMC optical fibers were successfully applied in touch sensing and respiratory rate monitoring. Finally, as a proof-of-concept, we demonstrate high-speed (150 Mbit/s) short-distance signal transmission using CMC fibers (at 1310 nm) in both air and water media. Our results establish the potential of carboxymethyl cellulose-based biocompatible optical fibers for highly demanding advanced sensor applications, such as in the biomedical domain.

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“…The increased synchrony observed in the EEG activity can be successfully treated with deep brain stimulation (DBS). Recent models have been proposed to investigate new targets for less invasive therapies by elucidating mechanisms supporting DBS [ 185 , 186 ]. Importantly, with the aim of developing novel DBS methods and optimizing the effects of DBS on patients, computational methods demonstrated that an increase in the DBS stimulation frequency tends to produce action potentials with higher variability and reduces significantly the alpha-beta power in almost all brain nuclei.…”

Section: Modeling Diseasesmentioning

confidence: 99%

Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders

Gandolfi

Boiani

Bigiani

et al. 2021

IJMS

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The investigation of synaptic functions remains one of the most fascinating challenges in the field of neuroscience and a large number of experimental methods have been tuned to dissect the mechanisms taking part in the neurotransmission process. Furthermore, the understanding of the insights of neurological disorders originating from alterations in neurotransmission often requires the development of (i) animal models of pathologies, (ii) invasive tools and (iii) targeted pharmacological approaches. In the last decades, additional tools to explore neurological diseases have been provided to the scientific community. A wide range of computational models in fact have been developed to explore the alterations of the mechanisms involved in neurotransmission following the emergence of neurological pathologies. Here, we review some of the advancements in the development of computational methods employed to investigate neuronal circuits with a particular focus on the application to the most diffuse neurological disorders.

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Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms

Cited by 54 publications

References 71 publications

Cerebellar stimulations prevent Levodopa-induced dyskinesia in mice and normalize brain activity

Cerebellar stimulations prevent Levodopa-induced dyskinesia in mice and normalize brain activity

Carboxymethyl Cellulose (CMC) Optical Fibers for Environment Sensing and Short-Range Optical Signal Transmission

Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders

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