Decreases in taurine levels induced by β-alanine treatment did not affect the susceptibility of tissues to lipid peroxidation

Parildar-Karpuzoglu, Hande; Doğru‐Abbasoğlu, Semra; Balkan, Jale; Aykaç‐Toker, Gülçin; Uysal, Müjdat

doi:10.1007/s00726-005-0282-x

Cited by 14 publications

(6 citation statements)

References 30 publications

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“…According to this, the balance between prooxidant and antioxidant systems seems to be highly sensitive to taurine depletion in the heart tissue of old rats. On the contrary, in our recent study, although the administration of 3% ␤-alanine in the drinking water of young rats decreased taurine levels in the heart (15%), this treatment was found not to alter endogenous, AA-or NADPH-induced lipid peroxidation in heart homogenates (38).…”

Section: Discussioncontrasting

confidence: 70%

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Parildar

Doğru‐Abbasoğlu

Mehmetçik

et al. 2008

J Nutr Sci Vitaminol

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SummaryThe aim of this study was to investigate the effect of the changes of taurine levels in the hearts of old rats on endogenous malondialdehyde (MDA) and diene conjugate (DC) levels and ascorbic acid (AA)-and NADPH-induced lipid peroxidation as well as nonenzymatic (glutathione, vitamin E and vitamin C) and enzymatic antioxidants (superoxide dismutase, glutathione peroxidase and glutathione transferase). Two groups of old (22 mo) rats were treated with ␤ -alanine (3%, w/v; in drinking water), a taurine depleting agent, or taurine (2% w/v; in drinking water) for 6 wk. Significant decreases were observed in taurine contents of hearts in old rats as compared to young (5 mo) rats. We found that MDA and DC levels and AA-and NADPH-induced lipid peroxidation increased, but non-enzymatic and enzymatic antioxidants did not alter in heart homogenates of aged rats. ␤ -Alanine administration resulted in significant decreases in heart taurine levels of old rats. This treatment did not cause further increases in MDA or DC levels or changes in antioxidants. However, AAand NADPH-induced lipid peroxidation was higher than that of old rats. Taurine treatment caused significant increases in heart taurine levels of old rats. This treatment was found to decrease endogenous MDA and DC levels without affecting the antioxidant system in the heart homogenates of aged rats. AA-and NADPH-induced lipid peroxidation was also reduced in old rats when given taurine, although not statistically significantly. Our results indicate that the changes in heart taurine levels may influence the susceptibility of heart tissue to lipid peroxidation in aged rats and that taurine supplementation has protective effects on age-dependent oxidative stress in heart tissue.

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Section: Discussioncontrasting

confidence: 70%

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Parildar

Doğru‐Abbasoğlu

Mehmetçik

et al. 2008

J Nutr Sci Vitaminol

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“…b-alanine is a competitive inhibitor of taurine to the taurine transporter activity. 1 Previous studies have shown that b-alanine treatment administered in the drinking water at a concentration of 3% causes a decline in taurine plasma levels [34][35][36] and in tissues such as the hippocampus, posterior cortex, and retina, as well as in cellular taurine content 13,14,[37][38][39][40] and also that taurine depletion causes loss of retinal neurons 6,41-43 (see below). [50][51][52] Light is a risk factor for some retinal degenerations, [53][54][55][56] and it accelerates photoreceptor degeneration in some inherited retinal degenerations.…”

Section: Discussionmentioning

confidence: 99%

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration

García‐Ayuso

Pierdomenico

Hadj-Saïd

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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METHODS. Albino rats received b-alanine in the drinking water to induce taurine depletion. One month later, half of the animals were exposed to white light (3000 lux) continuously for 48 hours and the rest remained in normal environmental conditions. A control group of animals nontreated with b-alanine also was prepared, and half of them were exposed to light using the same protocol. All the animals were processed 2 months after the beginning of the experiment. Retinas were dissected as wholemounts and immunodetected with antibodies against Brn3a, melanopsin, S-opsin, and L-opsin to label different retinal populations: Brn3a þ retinal ganglion cells (RGCs) (image-forming RGCs), m þ RGCs (non-image-forming RGCs), and S-and L/M-cones, respectively. RESULTS. Light exposure did not affect the numbers of Brn3aþ RGCs or m þ RGCs but diminished the numbers of S-and L/M-cones and caused the appearance of rings devoid of cones, mainly in an ''arciform'' area in the superotemporal retina. Taurine depletion caused a diminution of all the studied populations, with m þ RGCs the most affected, followed by Scones. Light exposure under taurine depletion increased photoreceptor degeneration but did not seem to increase Brn3a þ RGCs or m þ RGCs loss. CONCLUSIONS.Our results document that taurine is necessary for cell survival in the rat retina and even more under light-induced photoreceptor degeneration. Thus, taurine supplementation may help to prevent retinal degenerations, especially those that commence with S-cone degeneration or in which light may be an etiologic factor, such as inherited retinal degenerations, AMD, or glaucoma.

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“…TauT mediates the uptake of taurine from the extracellular space into the cell, thus maintaining high intracellular levels of taurine. To examine the pathophysiological role of taurine, models of taurine deficiency were developed by knocking out the TauT gene, nutritional depletion, an inhibitor of taurine intake, such as guanidinoethane sulfonate, or β‐alanine, and carbon tetrachloride (CCL 4 ), which time‐dependently significantly decreases taurine (86%) in the liver . Mitochondrial taurine content decreased by 60% after supplementation with β‐alanine .…”

Section: Models Of Taurine Deficiencymentioning

confidence: 99%

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Cui

Zhang

et al. 2018

Molecular Nutrition Food Res

136

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Energy metabolism is a basic and general process, by which the body acquires and uses energy to maintain normal function, and taurine plays a vital role in energy metabolism. Taurine deficiency may cause a weak energy metabolism and energy metabolism dysfunction. Taurine biosynthetic ability is limited, and its supplementation in the diet can strengthen energy metabolism in muscle performance, cardiac function, liver activity, and adipose tissue. Combining taurine with other drugs may have a superior effect in energy metabolism. In many metabolic disorders, taurine, or the combination of taurine with other drugs, also functions as a repair treatment for damaged tissues, and acts as a promoter for the balance of energy metabolism. The present study discusses the potential roles of taurine in energy metabolism.

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Decreases in taurine levels induced by β-alanine treatment did not affect the susceptibility of tissues to lipid peroxidation

Cited by 14 publications

References 30 publications

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Lipid Peroxidation Potential and Antioxidants in the Heart Tissue of .BETA.-Alanine- or Taurine-Treated Old Rats

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

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