Adenylyl cyclases are generally thought to be transmembrane-, G-protein-, and forskolin-responsive proteins, but a nontransmembrane, soluble adenylyl cyclase (sAC) 2 has been identified (1). Mammalian sAC is not activated by G-proteins or forskolin (1) but by HCO 3 Ϫ /CO 2 in a pH-independent manner (2, 3) and by Ca 2ϩ , which synergizes with HCO 3 Ϫ (4). sAC expression has been described in many human tissues (5). We have shown that it is expressed in the airway epithelium, where it represents the only known…
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