Decreased serum ferritin may be associated with increased restless legs syndrome in Parkinson’s disease (PD): a meta-analysis for the diagnosis of RLS in PD patients

Li, Kelu; Liu, Bin; Wang, Fang; Bao, Jianjian; Wu, Chongmin; Huang, Xiaodong; Hu, Fayun; Xu, Zhenhe; Ren, Hui; Yang, Xinglong

doi:10.1080/00207454.2019.1608200

Cited by 6 publications

(1 citation statement)

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“…High concentrations of iron detected in brain could induce neurotoxicity, leading to the death of dopaminergic neurons ( Ward et al, 2014 ). Many studies have indicated that the disturbance of iron metabolism plays a crucial role in non-motor symptoms in PD, including sleep disorder ( Hu et al, 2015 ), restless legs syndrome ( Li et al, 2019 ), depression and anxiety ( Xu et al, 2018 ). However, only a few studies have focused on the relationship between iron metabolism and apathy in PD.…”

Section: Introductionmentioning

confidence: 99%

A nomogram based on iron metabolism can help identify apathy in patients with Parkinson’s disease

Jiang-Ting

Gao

et al. 2023

Front. Aging Neurosci.

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BackgroundsApathy is common in Parkinson’s disease (PD) but difficult to identify. Growing evidence suggests that abnormal iron metabolism is associated with apathy in PD. We aimed to investigate the clinical features and iron metabolism of apathetic patients with PD, and construct a nomogram for predicting apathy in PD.MethodsData of 201 patients with PD were analyzed. Demographic data, Apathy Scale (AS) assessments, and serum iron metabolism parameters were obtained. Spearman correlations were used to assess relationships between AS scores and iron metabolism parameters, separately for male and female patients. Additionally, a nomograph for detecting apathetic patients with PD was built based on the results of logistic regression analysis.ResultsThe serum transferrin (TRF, p < 0.0024) concentration and total iron binding capacity (TIBC, p < 0.0024) were lower in the apathetic group after Bonferroni correction, and they were negatively associated with AS scores in male participants with PD (TRF, r = −0.27, p = 0.010; TIBC, r = −0.259, p = 0.014). The nomogram was developed by incorporating the following five parameters: age, sex, serum iron concentration, TIBC and Hamilton Depression Rating Scale (HAMD) scores, which showed good discrimination and calibration, with a consistency index of 0.799 (95% confidence interval = 0.732–0.865).ConclusionAbnormal iron metabolism may contribute to apathy in PD, especially among men. TIBC levels in combination with HAMD scores can be effectively used for the prediction of apathetic patients with PD.

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