Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-γ production of T cells

Pierkes, Melanie; Bellinghausen, Iris; Hultsch, T.; Metz, Gudrun; Knop, Jürgen; Saloga, Joachim

doi:10.1016/s0091-6749(99)70509-9

Cited by 107 publications

(75 citation statements)

References 28 publications

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“…Our data show that the effect of DNA immunization is dominant, since it prevents the subsequent induction by PLA 2 /alum of either an IgE Ab response or activation of Th2 cells producing IL-4; it can also reduce a pre-existing allergen-specific IgE response. Whether this is accompanied by the down-regulation of basophils and mast cell activation by IFN-␥ remains to be determined (29,30). The novelty of our data resides in the observation that the allergen does not need to be codelivered by the DNA plasmid, but its mere presence as an exogenously delivered protein after gene vaccination promotes naive CD4 ϩ T lymphocyte differentiation toward Th1 cells, leading to a second burst of IFN-␥ production in an allergen-dependent fashion.…”

Section: Discussionmentioning

confidence: 91%

Antigen-Independent Suppression of the Allergic Immune Response to Bee Venom Phospholipase A2 by DNA Vaccination in CBA/J Mice

Jilek

Barbey

Spertini

et al. 2001

The Journal of Immunology

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Phospholipase A2 (PLA2) is one of the major honey bee venom allergens for humans. To assess the long-term prevention of allergic reactions by DNA vaccination, a PLA2-CBA/J mouse model was employed using empty or PLA2 sequence-carrying DNA plasmids. Early skin application of either DNA construct before (prophylactic approach) or after (therapeutic approach) sensitization with PLA2/alum led to reduced PLA2-specific IgE and IgG1 titers at 7 mo, with concomitant rise in IgG2a and IgG3. Splenocytes recovered at 5–6 mo after the last DNA administration exhibited a sustained IFN-γ and IL-10 secretion and reduced IL-4 production. Recall challenge with PLA2 boosted IFN-γ and IL-10 secretion, suggesting the reactivation of quiescent memory Th1 lymphocytes. Mice from the prophylactic groups were fully protected against anaphylaxis, whereas 65% of the animals recovered in the therapeutic groups. Th1-polarized immune responses were also active in mice vaccinated with an empty plasmid 32 wk before sensitization with another Ag (OVA). This is the first demonstration that the Ag-coding sequence in DNA vaccine is not necessary to promote immune modulation in naive and sensitized animals for a prolonged period, and has relevance for the understanding of the innate and induced mechanisms underlying gene immunotherapy in long-term treatment of allergy.

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Section: Discussionmentioning

confidence: 91%

Antigen-Independent Suppression of the Allergic Immune Response to Bee Venom Phospholipase A2 by DNA Vaccination in CBA/J Mice

Jilek

Barbey

Spertini

et al. 2001

The Journal of Immunology

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“…As Treg cells are a major source of IL-10, it has been speculated that Treg cells secreting IL-10 are involved in the suppression of allergic Th2 responses in humans. Several human allergen-SIT studies supported this hypothesis [41,72,157]. In contrast, some studies demonstrated that increased IL-10 levels are not associated with less allergic disease [158].…”

Section: Clinical Relevance Of T-regulatory Cellsmentioning

confidence: 99%

T-Cell Regulatory Mechanisms in Specific Immunotherapy

Jutel

Akdiş²

2008

Chemical Immunology and Allergy

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“…La inmunoterapia modula de forma eficiente los umbrales para la activación de los mastocitos y los basófilos y reduce la liberación de histamina mediada por IgE, en parte por acción de las células Treg (24). A largo plazo, la inmunoterapia se asocia no solamente con una reducción de la reacción inmediata frente a la provocación con alérgenos, sino también de la reacción tardía en la mucosa respiratoria (nasal o bronquial) y en la piel (25).…”

Section: Efectos a Largo Plazounclassified

Inmunoterapia con alérgenos: mecanismos de acción, impacto terapéutico y socioeconómico. Consenso de la Asociación Colombiana de Alergias Asma e Inmunología

et al. 2016

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: idea central. Todos los autores participaron por igual en la redacción del manuscrito y la aprobaron la versión final. Las alergias constituyen un conjunto de enfermedades de gran prevalencia. Cuando los procesos alérgicos no se controlan, pueden poner en peligro la salud e, incluso, la vida de los pacientes y, además, su efecto económico y social es considerable. El objetivo de esta revisión es presentar un consenso práctico de la información científica disponible sobre el empleo de la inmunoterapia en las enfermedades alérgicas con la colaboración de varios institutos y universidades de Colombia, por solicitud de la Asociación Colombiana de Alergia, Asma e Inmunología. La revisión incluyó aspectos prácticos presentados desde el punto de vista de médicos generales, alergólogos, inmunólogos, internistas y pediatras con experiencia en el campo de las alergias. Con base en la evidencia científica actual a nivel nacional e internacional, se describió de forma detallada en qué consiste la inmunoterapia, sus indicaciones, contraindicaciones y sus beneficios para la salud, así como en el ámbito socioeconómico. Se concluyó que la inmunoterapia es efectiva y segura, y que, además, puede reducir sustancialmente el costo del tratamiento global de los pacientes alérgicos. Inmunoterapia con alérgenosPalabras clave: alérgenos, consenso, asma, anafilaxia, dermatitis, conjuntivitis, himenópteros, inmunoterapia, rinitis.doi: http://dx.doi.org/10.7705/biomedica.v36i3.3183 Allergen immunotherapy: Mechanisms of action, and therapeutic and socioeconomic impact Consensus of the Asociación Colombiana de Alergia, Asma e ImunologíaAllergies comprise a set of highly prevalent diseases. When allergic processes are not controlled, they can endanger patients' health and lives, and have an important economic and social impact. The aim of this paper is to present a practical consensus of the scientific evidence on the use of immunotherapy in allergic diseases. A collaborative review made by various institutes and universities in Colombia was carried out upon request of the Asociación Colombiana de Alergia, Asma e Imunología, led by general practitioners, allergists, immunologists, internists and paediatricians with experience in the field of allergies. As a result, based on current national and international scientific evidence, we describe in detail what immunotherapy is about, its indications, contraindications and its economic and health benefits.Conclusions show immunotherapy as a clinically effective and safe treatment, which can substantially reduce the cost of the overall treatment of allergic patients.

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Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-γ production of T cells

Cited by 107 publications

References 28 publications

Antigen-Independent Suppression of the Allergic Immune Response to Bee Venom Phospholipase A2 by DNA Vaccination in CBA/J Mice

Antigen-Independent Suppression of the Allergic Immune Response to Bee Venom Phospholipase A2 by DNA Vaccination in CBA/J Mice

T-Cell Regulatory Mechanisms in Specific Immunotherapy

Inmunoterapia con alérgenos: mecanismos de acción, impacto terapéutico y socioeconómico. Consenso de la Asociación Colombiana de Alergias Asma e Inmunología

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