Decreased plasma dehydroepiandrosterone sulfate and dihydrotestosterone concentrations in young men after myocardial infarction

Słowińska-Srzednicka, J; Zgliczyński, S; Ciświcka-Sznajderman, M; Srzednicki, M.; Soszyński, P; Biernacka, M; Woroszylska, M; Rużłło, W.; Sadowski, Zygmunt

doi:10.1016/0021-9150(89)90124-x

Cited by 73 publications

(39 citation statements)

References 46 publications

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“…Helaly et al found that patients with ACS had lower values of fT in comparison to control group [8]. In contradiction with these studies, as evidenced in our study, there are many studies showing no correlation between CAD and testosterone level [9][10][11][12][13][14]. These different results may be due to differences of assay methods and testosterone types.…”

Section: Discussioncontrasting

confidence: 99%

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Evaluation of Androgen Levels in Patients with Acute Coronary Syndrome

Dellal¹,

Niyazoğlu²,

Ceviker³

et al. 2012

Med-Science

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Section: Discussioncontrasting

confidence: 99%

“…Also Slowinska-Srzednicka et al found out a correlation between the low level of DHEA-S and occurrence of CAD. However, the same correlation was not found out between testosterone level and occurrence of CAD [12]. In our study we found that DHEA-S level was quite lower when compared with the level of control group.…”

Section: Discussioncontrasting

confidence: 39%

Evaluation of Androgen Levels in Patients with Acute Coronary Syndrome

Dellal¹,

Niyazoğlu²,

Ceviker³

et al. 2012

Med-Science

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“…On the other hand, other groups did not confirm these findings using coronary angiography in two male samples (119,120). Retrospective studies have examined whether myocardial infarction survivors were characterized by reduced DHEA-S levels compared with healthy controls (115,116,118). Two of these studies demonstrated that DHEA-S levels were lower in myocardial infarction survivors compared with healthy controls (115,116), while the third one found the opposite (116).…”

Section: Cardiovascular Diseasementioning

confidence: 97%

“…Several studies have identified plasma DHEA or DHEA-S as being cardioprotective (113)(114)(115)(116)(117)(118). In both men and women, elevated DHEA-S levels were associated with retarded progression of atherosclerosis measured by coronary artery angiography (113), ultrasound carotid wall thickness (117) and pulse wave velocity aorta calcification (114).…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Dehydroepiandrosterone, obesity and cardiovascular disease risk: a review of human studies

Tchernof

Labrie

2004

European Journal of Endocrinology

152

100

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The age-related decline in serum dehydroepiandrosterone (DHEA) and its sulfated ester (DHEA-S) has suggested that a relative deficiency of these steroids may be causally related to the development of chronic diseases generally associated with aging, including insulin resistance, obesity, cardiovascular disease, cancer, reductions of the immune defense, depression and a general deterioration in the sensation of well-being. The numerous studies which have focused on the link between DHEA and cardiovascular disease have generally been inconsistent, generating much debate and controversy on this issue. The present article is an analysis of studies on the relationship between endogenous DHEA or DHEA-S, obesity and cardiovascular disease risk, as well as DHEA treatment studies. Elevated plasma levels of free DHEA are associated with reduced obesity in both men and women, and with smaller abdominal body fat accumulations in men. However, contradictory results have been reported regarding the relationships between the sulfate ester DHEA-S and adiposity. Age differences in the populations studied may have been a confounding factor in these associations. On the other hand, DHEA-S level is not a predictor of cardiovascular disease endpoints in women, and appears to be a relatively weak one in men. DHEA intervention studies suggest that the effects of DHEA on serum lipids are, at best, modest or non-significant. The uncertainty as to whether endogenous and exogenous DHEA should be considered cardioprotective is related to discrepancies in the literature on this topic. Several studies may have been plagued by methodological problems such as low power, unreliable analytical methods, confounding factors or other differences in the populations studied. As a consequence, the original reports demonstrating dramatic effects of either endogenous or exogenous DHEA on cardiovascular disease risk have never been replicated. We propose that the effects of DHEA on cardiovascular disease risk (either favorable or unfavorable) should be considered to be much more modest than previously believed.

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“…3±5 Male survivors of myocardial infarction have also been shown to have reduced serum DHEAS in comparison with healthy matched controls. 6,7 In women, however, a prospective study failed to ®nd any relationship between DHEAS concentrations and ischaemic heart disease (IHD). 8 Experimentally induced hyperinsulinaemia lowers DHEAS concentrations 5 and weight loss decreases plasma insulin concentrations.…”

Section: Introductionmentioning

confidence: 99%