2004
DOI: 10.1161/01.atv.0000133488.56221.4a
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Abstract: Objective-Increased risk of cardiovascular disease in patients with chronic renal failure (CRF) has been explained by accelerated atherosclerosis and impaired angiogenesis, in which endothelial progenitor cells (EPCs) may play key roles. We hypothesized that altered EPC biology may contribute to the pathophysiology of CRF. Methods and Results-EPCs were isolated from CRF patients on maintenance hemodialysis (nϭ44) and from a normal control group (nϭ30). CRF patients showed markedly decreased numbers of EPC (44.… Show more

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Cited by 305 publications
(277 citation statements)
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“…In addition, previous studies have shown that the number and angiogenic activity of circulating CD34 þ endothelial progenitor cells decreases in patients with coronary artery disease or chronic renal failure. [29][30][31] In these patients, CD34 þ cells may be occupied in repairing coexisting disease in the ischemic area, or CD34 þ cell activity may be otherwise consumed, so the effective number of CD34 þ cells may be lower.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, previous studies have shown that the number and angiogenic activity of circulating CD34 þ endothelial progenitor cells decreases in patients with coronary artery disease or chronic renal failure. [29][30][31] In these patients, CD34 þ cells may be occupied in repairing coexisting disease in the ischemic area, or CD34 þ cell activity may be otherwise consumed, so the effective number of CD34 þ cells may be lower.…”
Section: Discussionmentioning
confidence: 99%
“…In patients with renal failure on hemodialysis, the number and colonyforming capacity of EPCs recovered from venous blood was decreased by Ͼ40%. 65 In addition, the EPCs from these patients showed reduced migratory activity and impaired ability to assemble into vascular tubes, suggesting that EPC deficiency may play a role in the progression of the disease.…”
Section: Epc and Cardiovascular Diseasesmentioning
confidence: 95%
“…Therefore, it is not surprising that CKD patients have qualitative and quantitative EPC alterations (53). Mechanisms are largely unknown, but uremic toxins may be involved, as both hemodyalisis and kidney transplantation can restore the endogenous EPC pool (54,55).…”
Section: Epcs and Diabetic Nephropathymentioning
confidence: 99%