Decreased Neurogenesis Increases Spatial Reversal Errors in Chickadees (<i>Poecile atricapillus</i>)

Guitar, Nicole A.; Sherry, David F.

doi:10.1002/dneu.22641

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…This ability seems to be affected by neurogenesis. Increased mistakes are detected in memory reversal test when hippocampal neurogenesis is reduced by methylazoximethanol acetate, supporting the possible relationship between adult hippocampal neurogenesis and separate patterns [111].…”

Section: Adult Neurogenesis In Birdsmentioning

confidence: 86%

Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Functional Similarities and Striking Controversies

Augusto-Oliveira

Arrifano

Malva

et al. 2019

Cells

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Adult neurogenesis occurs in many species, from fish to mammals, with an apparent reduction in the number of both neurogenic zones and new neurons inserted into established circuits with increasing brain complexity. Although the absolute number of new neurons is high in some species, the ratio of these cells to those already existing in the circuit is low. Continuous replacement/addition plays a role in spatial navigation (migration) and other cognitive processes in birds and rodents, but none of the literature relates adult neurogenesis to spatial navigation and memory in primates and humans. Some models developed by computational neuroscience attribute a high weight to hippocampal adult neurogenesis in learning and memory processes, with greater relevance to pattern separation. In contrast to theories involving neurogenesis in cognitive processes, absence/rarity of neurogenesis in the hippocampus of primates and adult humans was recently suggested and is under intense debate. Although the learning process is supported by plasticity, the retention of memories requires a certain degree of consolidated circuitry structures, otherwise the consolidation process would be hampered. Here, we compare and discuss hippocampal adult neurogenesis in different species and the inherent paradoxical aspects.

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Section: Adult Neurogenesis In Birdsmentioning

confidence: 86%

Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Functional Similarities and Striking Controversies

Augusto-Oliveira

Arrifano

Malva

et al. 2019

Cells

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“…2014; Audet et al. 2018; Guitar and Sherry 2018). If this is also true for lizards, this might explain why these cognitive abilities are more strongly selected against when resources are scarce.…”

Section: Discussionmentioning

confidence: 99%

“…A first explanation could be different costs of different traits. In other species, inhibitory control, problem-solving, and reversal learning are often associated with higher rates of adult neurogenesis (Burghardt et al 2012;Zhang et al 2012;Kalm et al 2013;Swan et al 2014;Audet et al 2018;Guitar and Sherry 2018). If this is also true for lizards, this might explain why these cognitive abilities are more strongly selected against when resources are scarce.…”

Section: Discussionmentioning

confidence: 99%

Learning with lacertids: Studying the link between ecology and cognition within a comparative framework

et al. 2022

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Cognition is an essential tool for animals to deal with environmental challenges. Nonetheless, the ecological forces driving the evolution of cognition throughout the animal kingdom remain enigmatic. Large-scale comparative studies on multiple species and cognitive traits have been advanced as the best way to facilitate our understanding of cognitive evolution, but such studies are rare. Here, we tested 13 species of lacertid lizards (Reptilia: Lacertidae) using a battery of cognitive tests measuring inhibitory control, problem-solving, and spatial and reversal learning. Next, we tested the relationship between species' performance and (a) resource availability (temperature and precipitation), habitat complexity (Normalized Difference Vegetation Index), and habitat variability (seasonality) in their natural habitat and (b) their life history (size at hatching and maturity, clutch size, and frequency). Although species differed markedly in their cognitive abilities, such variation was mostly unrelated to their ecology and life history. Yet, species living in more variable environments exhibited lower behavioral flexibility, likely due to energetic constrains in such habitats. Our standardized protocols provide opportunities for collaborative research, allowing increased sample sizes and replication, essential for moving forward in the field of comparative cognition. Follow-up studies could include more detailed measures of habitat structure and look at other potential selective drivers such as predation.

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“…Moreover, the abolishment of adult hippocampal neurogenesis results in deficits in long-term memory in the Morris water maze and the T-maze [29][30][31], meaning that hippocampal neurogenesis is essential for spatial working memory. Experiments on chickadees show that hippocampal neurogenesis aids in pattern separation and the differentiation of similar memories at the time of encod-ing [32]. Training rats in a Morris water maze supports adult hippocampal neurogenesis, but in a cell stage dependent manner: the enhancement of neurogenesis was detected only when BrdU was injected 6 days before the start of spatial training in the Morris maze [33], i.e., the training had an effect only on neural precursors that were born in a defined time window.…”

Section: Discussionmentioning

confidence: 99%

Enriched Environment Induces Sex-Specific Changes in the Adult Neurogenesis, Cytokine and miRNA Expression in Rat Hippocampus

et al. 2023

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An enriched environment stimulates adult hippocampal plasticity, but the exact cellular and molecular mechanisms are complex, and thus a matter of debate. We studied the behavior and hippocampal neurogenesis in adult male and female Wistar rats that were housed in an enriched environment (EE) for two months. Both EE males and females performed better than control animals in a Barnes maze, meaning that EE enhances spatial memory. However, the expression levels of neurogenesis markers KI67, DCX, Nestin, and Syn1 increased only in EE females, while in EE males only KI67 and BDNF were higher than in the corresponding control. The number of DCX+ neurons on brain slices increased in the dentate gyrus of EE females only, i.e., the level of adult hippocampal neurogenesis was increased in female but not in male rats. The level of anti-inflammatory IL-10 and signaling pathway components was upregulated in EE females. Of 84 miRNAs tested, in the hippocampi of EE female rats we detected upregulation in the expression levels of 12 miRNAs related to neuronal differentiation and morphogenesis, while in EE males four miRNAs were upregulated and involved in the regulation of cell proliferation/differentiation, and one was downregulated and associated with the stimulation of proliferation. Taken altogether, our results point to sex-specific differences in adult hippocampal plasticity, IL-10 expression, and miRNA profiles induced by an enriched environment.

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Decreased Neurogenesis Increases Spatial Reversal Errors in Chickadees (Poecile atricapillus)

Cited by 6 publications

References 48 publications

Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Functional Similarities and Striking Controversies

Adult Hippocampal Neurogenesis in Different Taxonomic Groups: Possible Functional Similarities and Striking Controversies

Learning with lacertids: Studying the link between ecology and cognition within a comparative framework

Enriched Environment Induces Sex-Specific Changes in the Adult Neurogenesis, Cytokine and miRNA Expression in Rat Hippocampus

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