Decreased natural killer cell activity in whole‐blood donors does not seem to result in increased cancer incidence

Lasek, W; Jakóbisiak, Marek; Stokłosa, Tomasz

doi:10.1046/j.1537-2995.1994.34494233589.x

Cited by 9 publications

(11 citation statements)

References 2 publications

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“…It must be emphasized, however, that in some studies there was no reduction in natural cytotoxicity in patients with cancers, irrespective of the stage of disease [175]. Moreover, studies of blood donors with a decreased NK activity did not seem to reveal an increased cancer incidence [176].…”

Section: The Role Of Nk Cells In the Immune Surveillancementioning

confidence: 94%

Natural mechanisms protecting against cancer

2003

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Section: The Role Of Nk Cells In the Immune Surveillancementioning

confidence: 94%

Natural mechanisms protecting against cancer

2003

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“…Three other studies, one of which overlapped with the Scandanavian study described above [9], reported no increase in the incidence of NHL among blood donors compared to the general population [10–12]. However, these null results may reflect the healthy lifestyle and other factors common among blood donors compared to general population [26].…”

Section: Discussionmentioning

confidence: 98%

A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma

Ishii¹,

Birmann²,

Zhang³

et al. 2015

Leukemia & Lymphoma

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Blood donation may influence subsequent NHL development via temporary immune system alterations. To test the hypothesis that frequent blood donation is associated with an increased risk of NHL and its most common histologic subtypes, we followed 36,576 men in the Health Professionals Follow-up Study (HPFS), who provided information on frequency of blood donation in the past 30 years in 1992. We confirmed 544 incident cases of NHL through 2010. Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% CI for the risk of all NHL and major NHL histologic subtypes associated with number of blood donations. In this prospective study, there was no significant evidence of an association between blood donation frequency and incidence of NHL (age-adjusted HR 1.26, 95% CI 0.94–1.68, comparing >20 donations vs. 0 donations over 30 years, p for trend = 0.18) or of any major NHL subtypes.

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“…The effect of blood donation on NK activity was first de scribed by Lasek et al [13] for long-term blood donors. This, however, was not associated with adverse clinical manifestations.…”

Section: Blood Transfusion and Nk And Lak Activitiesmentioning

confidence: 99%

“…Prospective randomized trials were designed to solve this topic of high clinical rele vance, where the immunosuppressive effect of allogeneic transfusion should have been controlled by the autologous blood transfusion, presumed to be immunological neutral [10,11], Recent investigations indicated that autologous blood donation itself provoked an immunosuppressive effect at the level of natural killer (NK) cell activity [12,13]. Further more, our own investigations showed an immunostimulatory potential of the autologous blood program on cell-medi ated immunity [14], also supported by recent findings of Kirkley et al [15] at the level of cytokines.…”

mentioning

confidence: 99%

Influence of Autologous Blood Transfusion on Natural Killer and Lymphokine-Activated Killer Cell Activities in Cancer Surgery

Jauch¹,

Schildberg²,

Heiss³

et al. 1997

Vox Sanguinis

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Background and objectives: Immunosuppression associated with blood transfusion may influence postoperative infection rates. It may also affect the prognosis of patients treated surgically for colorectal cancer. To control this effect, study protocols have applied autologous blood donation programs, which are thought to be immunologically neutral. However, evidence has emerged that blood donation itself might have suppressive effects on natural killer (NK) cell activities. At present, there are no data available on the effects of autologous blood transfusion on NK or lymphokine-activated killer (LAK) cells. This might be of interest as LAK cells may be active in tumor control. Materials and methods: 26 patients who underwent surgical resection for colorectal cancer, were assigned at random into two groups: (1) autologous blood donation and transfusion, or (2) allogeneic blood transfusion. NK and LAK activities were determined before blood donation, at surgery, and on the 3rd and 8th postoperative day. Results: Blood donation induced a small decrease in NK and LAK activities. The postoperative courses of the two groups differed. In the allogeneic group, NK activity (-50%, p = 0.018) and LAK activity decreased (-60.7%, p = 0.043), whereas in the autologous group the decline in LAK was less pronounced (-33.7%, p = 0.091), and their NK activity even increased (+17.4%, p = 0.315). NK activity was modulated differently in the two study groups (0.0036). Differences in LAK activities were found between the 3rd and 8th day postoperatively (p = 0.354). Conclusions: In patients receiving autologous blood transfusion, postoperative suppressed NK and LAK activities were modulated. This implies that autologous blood transfusion is not immunologically neutral, but has an intrinsic immunomodulatory potential.

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Decreased natural killer cell activity in whole‐blood donors does not seem to result in increased cancer incidence

Cited by 9 publications

References 2 publications

Natural mechanisms protecting against cancer

Natural mechanisms protecting against cancer

A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma

Influence of Autologous Blood Transfusion on Natural Killer and Lymphokine-Activated Killer Cell Activities in Cancer Surgery

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