Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

Otake, Sayaka; Takeda, Hiroaki; Fujishima, Shoichiro; Fukui, Tetsuya; Orii, Tomohiko; Satô, Takeshi; Sasaki, Yu; Nishise, Shoichi; Kawata, Satoshi

doi:10.3748/wjg.v16.i10.1252

Cited by 101 publications

(85 citation statements)

References 23 publications

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“…Nevertheless, one prospective study demonstrated that men with the highest concentrations had approximately 60% reduced risk for CRC compared to those with the lowest concentrations, even after adjustment for body size, WC, and physical activity (Wei et al, 2005). In contrast to prospective studies, among nine retrospective studies, only four studies have examined the association (Erarslan et al, 2009;Kumor et al, 2009;Gonullu et al, 2010;Kemik et al, 2010;Nakajima et al, 2010;Otake et al, 2010;Gialamas et al, 2011;Chen et al, 2012;Gulcelik et al, 2012). Of the four (Nakajima et al, 2010;Otake et al, 2010;Gialamas et al, 2011;Chen et al, 2012), three studies (Otake et al, 2010;Gialamas et al, 2011;Chen et al, 2012) found an inverse association between adiponectin and CRC and also suggested a protective effect of a high adiponectin level on CRC.…”

Section: Adiponectinmentioning

confidence: 99%

Obesity Related Adipokines and Colorectal Cancer: A Review and Meta-Analysis

Joshi¹,

Lee²

2014

Asian Pacific Journal of Cancer Prevention

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Obesity has been considered as an important risk factor for the development of colorectal cancer (CRC), but the association has not been fully elucidated. Obesity is linked significantly to adipose tissue dysfunction and to alteration of adipokines in blood; in particular, obesity-induced inflammation is thought to be an important link between obesity and colorectal cancer. Based on epidemiological studies, we undertook a systematic review to understand the association of circulating levels of selected adipokines, including adiponectin, leptin, resistin, IL-6 and TNF-α, with the level of CRC risk. Most prospective studies suggested protective effects of adiponectin, but these were attenuated by body mass index (BMI) and waist circumference (WC) data in our meta-analysis. On the other hand, meta-analyses for leptin and CRC did not demonstrate any association, similar to the results of systematic review. Although it proved difficult to determine whether other selected adipokines (resistin, IL-6 and TNF-α) were related to CRC risk due to small number of reports, the present systematic review suggested a positive association with elevated resistin levels but null associations with IL-6 and TNF-α.

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Section: Adiponectinmentioning

confidence: 99%

Obesity Related Adipokines and Colorectal Cancer: A Review and Meta-Analysis

Joshi¹,

Lee²

2014

Asian Pacific Journal of Cancer Prevention

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“…Colorectal cancer is the third most commonly diagnosed cancer in males and the second most commonly diagnosed cancer in females, with >1.2 million novel cancer cases and 608,700 mortalities estimated to occur each year. Despite considerable advances in modern therapeutic strategies, the overall survival time of patients undergoing complete resection of carcinomas is short (3). Therefore, clarification of the molecular mechanisms of colorectal carcinoma and the identification of a good biomarker to indicate the carcinogenesis and subsequent progression of the carcinoma is of considerable significance for the prevention, treatment and evaluation of prognosis of this disease.…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue

Wang

et al. 2015

Oncology Letters

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Abstract. The activation of mammalian target of rapamycin (mTOR) has been reported in tumor development, but the role of mTOR in colorectal carcinomas remains unclear. The aim of the present study was to investigate the significance of mTOR and its downstream effector 70 kDa ribosomal protein S6 kinase (P70S6K) in human colorectal carcinomas. The phosphorylated (p-)mTOR and p-P70S6K proteins were examined by immunohistochemistry performed on tissue microarray containing tissue samples obtained from colorectal carcinoma (n=111), adenomatous polyps (n=40) and normal colonic mucosa (n=40), with a comparison between the expression of these proteins and the clinicopathological parameters of patients with carcinomas. The positive expression rates of p-mTOR and p-P70S6k were 60.4 and 65.8%, respectively, in colorectal carcinoma tissue, which was significantly increased compared with the tissue from adenomatous polyps (27.5 and 20%, respectively) and normal colonic mucosa (10.0 and 5.0%, respectively) (P<0.05). Overexpression of the p-mTOR and p-P70S6K proteins was significantly associated with the tumor-node-metastasis stage, the occurrence of distal and lymph node metastasis and the degree of differentiation. Aberrant expression of p-mTOR and p-P70S6K may contribute to the pathogenesis, growth, invasion and metastasis of colorectal carcinoma. The phosphorylation of these proteins was considered to be a promising marker to indicate the aggressive behaviors and prognosis of colorectal carcinomas. The overexpression of the mTOR/P70S6K signaling pathway may play an important role in colorectal carcinoma carcinogenesis. The expression of p-mTOR and p-P70S6K was considered as a promising marker to indicate the aggressive behaviors and prognosis of human colorectal carcinomas.

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“…A decreased level of adiponectin was recognized as a strong risk factor for early CRC [6]. Two types of adiponectin receptors, AdipoR1 and AdipoR2, may be intimately related to the progression of CRC [13].…”

Section: Introductionmentioning

confidence: 99%

“…They have recently become the focus of research on the role of obesity in carcinogenesis. Several adipocytokines, namely leptin, adiponectin, visfatin and resistin, have been under investigation in a multitude of robust in vitro and epidemiological studies carried out to clarify the association between obesity and CRC [5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Circulating levels of novel adipocytokines in patients with colorectal cancer

et al. 2013

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a b s t r a c tObjective: Adipocytokines have been reported to contribute to the pathogenesis of colorectal cancer (CRC). The aim of this matched case-control study was to explore circulating novel adipocytokines, such as serum visfatin, omentin-1 and vaspin levels in patients with CRC. Method: Serum visfatin, omentin-1, and vaspin levels were measured in 69 subjects (39 patients with colorectal cancer and 30 age-and sex-matched healthy controls) using enzyme-linked immunosorbent assay (ELISA) methods. Results: Compared with the controls, patients with CRC had significantly higher circulating omentin-1 (203.23 vs 9.12 ng/ml, p < 0.0001) visfatin (4.03 vs 2.01 ng/ml, p < 0.0001) and vaspin (0.54 vs 0.31 ng/ ml, p = 0.015) levels. After adjustment for covariates (age and body mass index), patients with CRC had significantly higher serum omentin-1 (p < 0.0001), visfatin (p < 0.0001), and vaspin (p = 0.040) levels than the control group. Furthermore, the results did not change when age and waist-to-hip ratio were considered as covariates in the general linear models. Conclusions: The observed higher levels of omentin-1, visfatin, and vaspin in patients with CRC, independent of measures of obesity, suggest that these adipocytokines may have a potential role in the development of CRC through mechanisms other than the indirect mechanisms that are active in the association between obesity and CRC.

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Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

Abstract: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study.

Cited by 101 publications

References 23 publications

Obesity Related Adipokines and Colorectal Cancer: A Review and Meta-Analysis

Obesity Related Adipokines and Colorectal Cancer: A Review and Meta-Analysis

Expression and clinical significance of mammalian target of rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma tissue

Circulating levels of novel adipocytokines in patients with colorectal cancer

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