2010
DOI: 10.1017/s1461145710000805
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Abstract: Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ). Glutathione (GSH) is the major free radical scavenger in the brain. Diminished GSH levels elevate cellular vulnerability towards oxidative stress; characterized by accumulating reactive oxygen species. The aim of this study was to determine if mood disorders and SCZ are associated with abnormal GSH and its functionally related enzymes. Po… Show more

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Cited by 480 publications
(316 citation statements)
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“…In addition to schizophrenia, these findings may be relevant to other GSH-deficit-related psychiatric disorders, including bipolar disorder or major depressive disorder, which are both associated with white matter abnormalities. 18,65 A better understanding of molecular mechanisms underlying redox control of myelination at various developmental vulnerability periods will pave the way toward new drug targets and strategies for the treatment and prevention of schizophrenia.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition to schizophrenia, these findings may be relevant to other GSH-deficit-related psychiatric disorders, including bipolar disorder or major depressive disorder, which are both associated with white matter abnormalities. 18,65 A better understanding of molecular mechanisms underlying redox control of myelination at various developmental vulnerability periods will pave the way toward new drug targets and strategies for the treatment and prevention of schizophrenia.…”
Section: Discussionmentioning
confidence: 99%
“…[11][12][13][14] In some studies, decreased glutathione (GSH) levels, the main cellular non-protein antioxidant and redox regulator, 10,15 have been reported in the cerebrospinal fluid and prefrontal cortex of patients by using magnetic resonance spectroscopy (MRS) 16,17 and in post-mortem tissues. 14,18 We thus proposed that a redox dysregulation represents one hub on which converge various causal genetic and environmental risk factors during neurodevelopment, leading to structural and functional connectivity impairments. The genetic vulnerability factors involve either redox regulation genes directly affecting GSH metabolism, [19][20][21][22] or genes that indirectly lead to oxidative stress, including DISC1, PROD, G72, NRG and DTNBP1.…”
Section: Introductionmentioning
confidence: 99%
“…Behavioral paradigms in rodents that are depressogenic (e.g., restraint stress, forced swim test) increase lipid peroxidation in several tissues (Sahin et al ., 2004; Lucca et al ., 2009; Runkel et al ., 2013; Spiers et al ., 2013). Similarly, tissue samples from psychiatric patients show increased levels of lipid peroxidation and depletion of antioxidant activities compared to samples from healthy controls (Do et al ., 2000; Bilici et al ., 2001; Gawryluk et al ., 2011; Ditzen et al ., 2012). These effects on oxidative defense systems may be more than just an indirect correlation, as suggested by experiments showing that certain antioxidants have antidepressant‐like effects in rodents as well as in humans (Ferreira et al ., 2008).…”
Section: Introductionmentioning
confidence: 99%
“…123,124 Depleted levels of glutathione (GSH) have also been found in postmortem prefrontal cortex samples of patients with psychiatric disorders. 125 Diminished GSH levels affect mitochondrial function and inhibit the activity of the mitochondrial complexes, especially complex I. 126 Although no molecules that induce OCD symptoms have been identified, several neurotransmitters, including serotonin, dopamine, glutamate and gamma-aminobutyric acid (GABA), have been suggested to play regulatory roles in OCD.…”
Section: Obsessive-compulsive Disordermentioning
confidence: 99%