Decreased glutathione-S-transferase activity: Diagnostic and protective role in vivax malaria

Antioxidant and Antimalarial Activity of Leea indica leaf extract against Malaria-mice Model

“…Another study also reported that in an extract, the hydroxyl radical scavenging activity is equivalent to its antioxidant activity which is represented by the decrease intensity of red colour (Gulcin et al, 2005). In this study, methanolic extract had the highest hydroxyl scavenging activity, better than the positive control vitamin C. The antioxidant potency increases as the increase of the polarity of solvent, consistent with the total phenolic and flavonoid compounds, which exhibit an antioxidant capacity by blocking lipid free radicals or preventing degradation of hydroperoxides into free radicals (Soumaya et al, 2014). This result favors the methanolic extract for further study by analyzing its antimalarial potency.…”

“…The idea of using an antioxidant as a therapy for malaria because the oxidative stress is considered plays an important role in the malaria pathogenesis. There are several hypothetical pathogenic mechanisms, including the parasite induction (Potter et al, 2005), the production of free radical (Keller et al, 2004) as well as antioxidant defenses (Sohail et al, 2007) by host cells to decrease the infection. In malaria pathogenesis, the oxidative stress are especially caused by the digestion of erythrocyte hemoglobin and production of heme within vacuoles, the translation of protein within the endoplasmic reticulum and the generation of the energy in the mitochondria, where the systems acts as antioxidant are ineffective on highly reactive free radicals, causing oxidative pathological processes.…”

Augmentation of antioxidant system: Contribution to antimalarial activity of Clerodendrum violaceum leaf extract

“…Production of ROS species by the immune cells and the synchronized release of O 2 -during haemoglobin degradation by the malaria parasites might have contributed to the depletion of SOD possibly by overstressing the induction of its synthesis (Sohail et al, 2007). Furthermore, the antioxidant enzymes degraded by malaria parasites to derive amino acids cannot be replenished by the red blood cells due to lack of machinery for protein synthesis (Das and Nanda, 1999).…”

“…It has been shown that trophozoite infected human red cells produce twice as much hydrogen peroxide and hydroxyl radicals as normal erythrocytes (Sohail et al, 2007). Increased intracellular iron levels from haemolysis can also lead to an increased production of hydrogen peroxide and hydroxyl ions (Vander et al, 1992).…”

Activities of Three Erythrocyte Enzymes of Hyperglycemic Rats (Rattus norvegicus) Treated with Allium sativa Extract.

“…Erythrocyte GST activity has been proven to be a reliable biochemical index and the basis for diagnosis and monitoring of therapeutic events in the course of treatment and management of other pathologic/metabolic disorders whose etiologies and manifestations are linked to oxidative stress. Notable among which are: parasitic infections, [26,54] gout and rheumatoid arthritis, [55,56] haemoglobinopathies, [26] malignancy, [57] hypertension, [58] stroke [59] and atherosclerosis. [60] In a related perspective, the use of GT activity as a reliable biomarker in depicting the etiology of diabetes mellitus has been described.…”