Decreased Filaggrin Level May Lead to Sweat Duct Obstruction in Filaggrin Mutant Mice

Abstract

tion of b-catenin does not increase dermal papilla cell number in the hair follicle.

Skin tape proteomics identifies pathways associated with transepidermal water loss and allergen polysensitization in atopic dermatitis

“…47 The decreased levels of KRT77 in STS of patients with AD identified in our study and significant negative correlation with TEWL may suggest previously unrecognized decreased eccrine sweat glands density in AD skin. Of interest, reduced sweat production, sweat glands obstruction, and abnormalities in sweat gland morphology have been found in the footpads of Flg mutant mice as compared to wild-type mice, 50 also suggesting a potential regulation of sweat glands by Flg. Our data demonstrate a significant positive correlation between KRT77 levels in STS and levels of FLG in the same skin site as determined by FLG breakdown products PCA and UCA.…”

Role of antimicrobial peptides in atopic dermatitis

“…67 These inconsistent results indicated that the dysfunction of sweat glands and delivery system might play a role in AD. 72 The studies on filaggrin mutant mice demonstrate that decreased filaggrin levels lead to acrosyringium obstruction and eventually gives rise to sweating impairment, 73 which could indirectly affect dermcidin activity.…”

A new era for translational atopic dermatitis research and management

“…Sweat contributes to the functioning of the cutaneous barrier and shapes the cutaneous microbiome. Impairment of sweating along with reduced levels of dermcidin, an antimicrobial peptide specific for sweat, has been reported in atopics, but the available data on this remain controversial. Thus, new methods to approach and measure “sweating,” sweat glands and ducts to assess the contribution of “sweat” to AD pathogenesis are important and are expected to evolve so that stratification of patients with AD into “sweaters” and sweating‐impaired subgroups can be accomplished.…”