Decreased expression of ATP6V1H in type 2 diabetes: A pilot report on the diabetes risk study in Mexican Americans

Molina, Melanie F.; Qu, Hui‐Qi; Rentfro, Anne R.; Nair, Saraswathy; Yang, Lu; Hanis, Craig L.; McCormick, Joseph B.; Fisher‐Hoch, Susan P.

doi:10.1016/j.bbrc.2011.08.041

Cited by 23 publications

(18 citation statements)

References 33 publications

(32 reference statements)

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“…Hence, RAB6A, which is a central gene in the AD metastable network described in this work, could play an important role in the regulation of the metastable proteins by directing them toward the endosomallysosomal degradation machinery, thereby preventing their accumulation in the cytoplasm. Another two genes in the group that we found are ATP6V1H, which encodes a protein subunit of a vacuolar ATPase involved in clathrin-mediated endocytosis (57,58) and whose role in regulating lysosomal pH has been recently been linked to neurodegeneration (59), and ATL1, which is involved in ER trafficking (60,61). In fact, all 10 genes that we found to be related to trafficking are part of the endosomal-lysosomal system.…”

Section: Test Of Module Generality Using a Consensus Network Analysismentioning

confidence: 72%

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

Kundra

Ciryam

Morimoto

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Alzheimer's disease is the most common cause of dementia. A hallmark of this disease is the presence of aberrant deposits containing by the Aβ peptide (amyloid plaques) and the tau protein (neurofibrillary tangles) in the brains of affected individuals. Increasing evidence suggests that the formation of these deposits is closely associated with the age-related dysregulation of a large set of highly expressed and aggregation-prone proteins, which make up a metastable subproteome. To understand in more detail the origins of such dysregulation, we identify specific components of the protein homeostasis system associated with these metastable proteins by using a gene coexpression analysis. Our results reveal the particular importance of the protein trafficking and clearance mechanisms, including specific branches of the endosomal-lysosomal and ubiquitin-proteasome systems, in maintaining the homeostasis of the metastable subproteome associated with Alzheimer's disease.Alzheimer's disease | protein aggregation | protein homeostasis | supersaturation

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Section: Test Of Module Generality Using a Consensus Network Analysismentioning

confidence: 72%

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

Kundra

Ciryam

Morimoto

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…Other polymorphisms near SOCS3 have been associated with obesity and glucose homeostasis traits in Hispanic Americans. The SOCS3 gene product participates in the feedback inhibition of a range of cytokine signals and has been shown to inhibit the function of leptin and insulin signalling, thus contributing to insulin resistance …”

Section: Pathophysiology Of T2dmentioning

confidence: 81%

“…Also, T2D seemed to develop more frequently in an MA population that had a decrease in the expression of ATP6VIH, which could have an effect on vacuolar‐ATPase activity and have subsequent consequences on insulin secretion …”

Section: Pathophysiology Of T2dmentioning

confidence: 81%

“…The SOCS3 gene product participates in the feedback inhibition of a range of cytokine signals and has been shown to inhibit the function of leptin and insulin signalling, thus contributing to insulin resistance. 64,65 Also, T2D seemed to develop more frequently in an MA population that had a decrease in the expression of ATP6VIH, which could have an effect on vacuolar-ATPase activity and have subsequent consequences on insulin secretion. 65 The R230C variant of the ATP-binding cassette transporter A1 (ABCA1) gene has been consistently associated with decreased highdensity lipoprotein-cholesterol (HDL-C) concentrations in studies in the Mexican mestizo population.…”

Section: Genetic Predispositionmentioning

confidence: 99%

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Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States

Aguayo-Mazzucato

Diaque

Hernandez

et al. 2018

Diabetes Metabolism Res

145

130

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Summary The prevalence and incidence of type 2 diabetes (T2D) among the Hispanic population in the United States are higher than the national average. This is partly due to sociocultural factors, such as lower income and decreased access to education and health care, as well as a genetic susceptibility to obesity and higher insulin resistance. This review focuses on understanding the Hispanic population living in the United States from a multidisciplinary approach and underlines the importance of cultural, social, and biological factors in determining the increased risk of T2D in this population. An overview of the acute and chronic complications of T2D upon this population is included, which is of paramount importance to understand the toll that diabetes has upon this population, the health system, and society as a whole. Specific interventions directed to the Hispanic populations are needed to prevent and alleviate some of the burdens of T2D. Different prevention strategies based on medications, lifestyle modifications, and educational programmes are discussed herein. Diabetes self‐management education (DSME) is a critical element of care of all people with diabetes and is considered necessary to improve patient outcomes. To be more effective, programmes should take into consideration cultural factors that influence the development and progression of diabetes. These interventions aim to enhance long‐term effects by reducing the incidence, morbidity, and mortality of T2D in the Hispanic population of the United States.

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“…In a longitudinal follow-up of individuals transitioning from pre-DM to DM, researchers noted a reduction in the expression of genes encoding for products that contribute to anti-mycobacterial activities of phagocytes: i) the vacuolar ATPase (ATP6V1H) acidifies the phagosome-lysosome compartment and facilitates Mtb killing; 47 ii) the hexokinase 2 (HK2) is an enzyme involved in aerobic glycolysis which is the main energy source for macrophages, and iii) CD28 is required for effective co-stimulation of T lymphocytes by antigen-presenting cells. 48 Functional studies are needed to confirm the relationship between these alterations in gene expression in DM and Mtb susceptibility.…”

Section: Impact Of Dm On the Natural History Of Tbmentioning

confidence: 99%

Host-pathogen interactions in tuberculosis patients with type 2 diabetes mellitus

Restrepo¹,

Schlesinger²

2013

Tuberculosis

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Tuberculosis (TB) is known to be fueled by HIV as well as social and economic factors. With progression of the diabetes mellitus (DM) pandemic in countries where TB is also endemic, focus is increasing on the potential links between DM and TB. Despite the magnitude of the DM-TB association woldwide, it is striking how little we know about the underlying biology that promotes this association which is a major concern to public health. In this review we summarize current findings regarding the alterations in the innate and adaptive immune responses of DM patients to Mycobacterium tuberculosis (Mtb). Current findings suggest underperforming innate immunity followed by a hyper-reactive cellular response to Mtb, but the contribution of these altered responses to TB susceptibility or to the more adverse clinical outcomes of TB patients with DM remains unclear. Elucidating the basic mechanisms underlying the higher susceptibility of DM patients to TB should lead to a strategy for stratification of the millions of DM patients worldwide into those with the highest TB risk for targeted TB prevention.

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Decreased expression of ATP6V1H in type 2 diabetes: A pilot report on the diabetes risk study in Mexican Americans

Cited by 23 publications

References 33 publications

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

Understanding the growing epidemic of type 2 diabetes in the Hispanic population living in the United States

Host-pathogen interactions in tuberculosis patients with type 2 diabetes mellitus

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