Decreased bacterial colonization of additively manufactured Ti6Al4V metallic scaffolds with immobilized silver and calcium phosphate nanoparticles

Surmenev, Roman A.; Lapanje, Aleš; Chudinova, Ekaterina; Ivanova, Anna A.; Koptyug, Andrey; Loza, Κateryna; Prymak, Oleg; Epple, Matthias; Ennen-Roth, Franka; Ulbricht, Mathias; Rijavec, Tatjana

doi:10.1016/j.apsusc.2019.03.003

Cited by 50 publications

(35 citation statements)

References 54 publications

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“…Biodegradable polymers with tunable degradation rates could be both natural (from human or animal tissues) and synthetic. Their degradation rate depends on molecular weight, the structural arrangement of macromolecules (amorphous/crystal structure), isomeric characteristics, formulation, architecture, and quantity of the material [[109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126], [127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151]]. Natural polymer scaffolds usually demonstrate a lack of immune response and better cell interactions while synthetic polymers are cheaper, stronger, and have better functionality although sometimes triggering immune response and toxicity [37].…”

Section: Scaffolds For Hard Tissue Applicationmentioning

confidence: 99%

“…Another approach aiming at increasing the bioactivity and biocompatibility of metal implants is deposition of wollastonite (CaSiO 3 ) [129], calcium phosphate [130], biomimetic nanoapatite [131], or polycrystalline diamond [132] coatings on different titanium scaffolds. When EBM-manufactured Ti6Al4V scaffold was functionalized with Ag and CaP nanoparticles via electrophoretic deposition, the change in hydrophobicity and surface roughness at nanoscale provided physical cues that disrupted bacterial adhesion [133]. The silver nanoparticles at concentration 0.02 mg/cm 2 in CaP film covered with positively charged PEI indicated bacteriostatic activity against gram positive bacteria, S. aureus, during 17 h of exposition.…”

Section: Scaffolds For Hard Tissue Applicationmentioning

confidence: 99%

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Recent advances in biomaterials for 3D scaffolds: A review

Nikolova

Chavali

2019

Bioactive Materials

648

442

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Considering the advantages and disadvantages of biomaterials used for the production of 3D scaffolds for tissue engineering, new strategies for designing advanced functional biomimetic structures have been reviewed. We offer a comprehensive summary of recent trends in development of single- (metal, ceramics and polymers), composite-type and cell-laden scaffolds that in addition to mechanical support, promote simultaneous tissue growth, and deliver different molecules (growth factors, cytokines, bioactive ions, genes, drugs, antibiotics, etc.) or cells with therapeutic or facilitating regeneration effect. The paper briefly focuses on divers 3D bioprinting constructs and the challenges they face. Based on their application in hard and soft tissue engineering, in vitro and in vivo effects triggered by the structural and biological functionalized biomaterials are underlined. The authors discuss the future outlook for the development of bioactive scaffolds that could pave the way for their successful imposing in clinical therapy.

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Section: Scaffolds For Hard Tissue Applicationmentioning

confidence: 99%

Section: Scaffolds For Hard Tissue Applicationmentioning

confidence: 99%

Recent advances in biomaterials for 3D scaffolds: A review

Nikolova

Chavali

2019

Bioactive Materials

648

442

View full text Add to dashboard Cite

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“…The surface free energy (SFE) was analyzed using the sessile drop method with a goniometer (Ramé-Hart 10000; Ramé-hart instrument co.) with different treatments using the SCA-20 software with the Young-Laplace equation [ 21 ]. The contact anglewas measured using fluids differing in hydrophobicity (distilled water, glycerol, and diiodomethane) [ 21 ] at a controlled temperature (25 °C) and after the settling time (30s) of the drop (15 μL). The disks of each subgroup (N = 100) were measured 3 times, and the average of each surface and fluid was analyzed as described by Owens and Wendt [ 22 ] in the software SCA 20 (DataPhysics Instruments GmbH).…”

Section: Methodsmentioning

confidence: 99%

Comparison of Ti–35Nb–7Zr–5Ta and Ti–6Al–4V hydrofluoric acid/magnesium-doped surfaces obtained by anodizing

Reis

Fais

Ribeiro

et al. 2020

Heliyon

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Objectives Development of a new generation of stable β alloy, free of aluminum or vanadium and with better biological and mechanical compatibility and evaluate the surface properties of Ti–6Al–4V and Ti–35Nb–7Zr–5Ta after anodization in hydrofluoric acid, followed by deposition of different electrolyte concentrations of magnesium particles by micro arc-oxidation treatment. Methods Disks were anodized in hydrofluoric acid. After this first anodization, the specimens received the deposition of magnesium using different concentration (8.5% and 12.5%) and times (30s and 60s). The surface morphology was assessed using scanning electron microscopy, and the chemical composition was assessed using energy dispersive x ray spectroscopy. The surface free energy was measured from the contact angle, and the mean roughness was measured using a digital profilometer. Results Anodization in hydrofluoric acid provided the formation of nanotubes in both alloys, and the best concentration of magnesium considered was 8.5%, as it was the condition where the magnesium was incorporated without covering the morphology of the nanotubes. X-ray dispersive energy spectroscopy showed magnesium incorporation in all conditions. The average roughness was increased in the Ti–35Nb–7Zr–5Ta alloy. Conclusions It was concluded that anodizing could be used to deposit magnesium on the surfaces of Ti–6Al–4V and Ti–35Nb–7Zr–5Ta nanotubes, with better results obtained in samples with magnesium concentration in 8.5% and the process favored the roughness in the Ti–35Nb–7Zr–5Ta group.

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“…The silver ions released by the silver NPs are highly mobile, and their entrance into living cells with high concentrations can kill healthy cells ( AshaRani et al, 2009 ). The silver element forms which served as antibacterial are Ag2O NPs ( Chen et al, 2017 ; Sarraf et al, 2018a ; Lv et al, 2019 ) and Ag NPs ( Cheng et al, 2019 ; Pruchova et al, 2019 ; Surmeneva et al, 2019 ). The silver NPs that were loaded on the surface of the titanium substrate to produce NS, showing different antibacterial effects and performance that is listed in Table 3 .…”

Section: Nanomaterials Loadingmentioning

confidence: 99%