2013
DOI: 10.1159/000345905
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Abstract: Background/Aims: Endogenous Cushing's syndrome is associated with a higher risk of cardiovascular morbidity and mortality. Previous literature suggested multiple possible links by which hypercortisolism may alter the autonomic control of cardiovascular functions. We investigated the impact of chronic endogenous hypercortisolism on the autonomic regulation of cardiac functions by short-term heart rate variability analysis. Methods: Eighteen patients with endogenous Cushing's syndrome and 20 age-, gender- and BM… Show more

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Cited by 19 publications
(13 citation statements)
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“…Altered autonomic cardiac regulation can contribute to the overall increased cardiovascular risk. Several studies found abnormalities in cardiovascular autonomic regulation in CS patients, as suggested by reduced heart rate variability (189,190).…”
Section: European Journal Of Endocrinologymentioning
confidence: 99%
“…Altered autonomic cardiac regulation can contribute to the overall increased cardiovascular risk. Several studies found abnormalities in cardiovascular autonomic regulation in CS patients, as suggested by reduced heart rate variability (189,190).…”
Section: European Journal Of Endocrinologymentioning
confidence: 99%
“…Heart failure and dilated cardiomyopathy [38,39] may be the first manifestations of CS. Non-diabetic patients with CS show decreased heart rate variability independently of their hypertensive status [40], and impaired sympathetic reactivity [41] which tends to normalize six months after cure. Increased stiffness and intima media thickness are observed at carotid [42] and aortic sites [43].…”
Section: Cardiovascular and Cerebrovascular Manifestationsmentioning
confidence: 99%
“…However, in humans, increased cortisol concentrations and a reduced birth weight are associated with a reduced parasympathetic tone, diseases later in life, increased mortality, and behavior changes (Chandran et al . , De Bock et al . , Rakow et al .…”
mentioning
confidence: 99%
“…In humans, a development over several years is known; this is likely to be shorter in free-ranging seals. However, in humans, increased cortisol concentrations and a reduced birth weight are associated with a reduced parasympathetic tone, diseases later in life, increased mortality, and behavior changes (Chandran et al 2013, De Bock et al 2013, Rakow et al 2013. It is therefore possible that in seals exposed to different stress factors, such as diseases or an unfamiliar environment, the development of the autonomic nervous system is delayed.This might be of particular interest for seal pups rehabilitated in seal centers.…”
mentioning
confidence: 99%
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