Decreased Adiponectin Levels in Polycystic Ovary Syndrome, Independent of Body Mass Index

Sharifi, Faranak; Hajihosseini, Reza; Mazloomi, Sahar; Amirmogaddami, Hamidreza; Nazem, Habibollah

doi:10.1089/met.2009.0036

Cited by 16 publications

(12 citation statements)

References 42 publications

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“…Moreover, the resulting hyperandrogenism is thought to contribute further to low synthesis of adiponectin and its receptors in adipose tissues . Our low adiponectin level in PCOS women is in agreement with others . Toulis et al .…”

Section: Discussionsupporting

confidence: 93%

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Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome

Hamed

2013

J of Obstet and Gynaecol

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Aims: The aim of this study was to examine the effect of metformin on serum adiponectin and adiponectin receptor-1 (AdipoR1) and evaluate their role in prediction of ovulation in patients with polycystic ovarian syndrome (PCOS). Material and Methods:The study cohort included 68 PCOS patients with clomiphene citrate resistance (group 1) and 28 healthy women as controls (group 2). Baseline serum adiponectin, AdipoR1, total testosterone (T), and homeostasis model of insulin resistance (HOMA-IR) were measured in all participants. Group 1 received metformin (1500 mg/day) for 6 months followed by second blood sampling. Results: Group 1 had significantly lower baseline adiponectin and AdipoR1 (P = 0.001) compared to group 2. During treatment, metformin resulted in conception in 5/68 (7%), ovulation in 33/68 (48%) and regular cycles in 41/68 (60%) patients. Group 1 showed post-metformin higher adiponectin and AdipoR1 (P = 0.01) and lower HOMA-IR (P = 0.006) and T (P = 0.001) compared to pre-treatment levels. Post-metformin ovulatory patients had higher adiponectin and AdipoR1 and lower HOMA-IR and T compared to anovulatory patients. Multivariate regression analysis in group 1 showed that only T and HOMA-IR were significant independent factors for predicting ovulatory cycles during metformin treatment (P = 0.04 and P = 0.05, respectively). Conclusions: Metformin treatment enhances both adiponectin activity and insulin sensitivity, resulting in a less hyperandrogenic state in patients with PCOS. Serum adiponectin and AdipoR1 are poor predictors of ovulatory outcome during treatment.

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Section: Discussionsupporting

confidence: 93%

“…The studies addressing serum adiponectin in PCOS patients are conflicting. Although some have reported decreased adiponectin levels compared to BMI‐matched controls, others have shown no difference after controlling for obesity . Whether this decline is secondary to associated obesity or IR is not clear .…”

Section: Introductionmentioning

confidence: 99%

Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome

Hamed

2013

J of Obstet and Gynaecol

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“…Regarding on a confirmed association of low adiponectin concentration in PCOS and its relation to insulin resistance independent of BMI [15], a good explanation for the above findings would be that hypoadiponectinemia may be due to decreased concentrations of vitamin D metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…PCOS can be considered as the most frequent cause of anovulation [13] and is a prevalent endocrine disorder among women [14]. Insulin resistance with compensatory hyperinsulinaemia and low adiponectin concentrations independent of BMI has been reported in PCOS [15]. However, calcium and vitamin D concentrations in women with PCOS and their relationship with adiponectin have not been thoroughly studied.…”

Section: Introductionmentioning

confidence: 99%

Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

et al. 2012

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Objective. To investigate the possible association of calcium and vitamin D deficiency with hypoadiponectinemia in women with PCOS. Subjects and Methods. In this case-control study, 103 PCOS cases and 103 controls included. The concentrations of calcium, 25-OH-vitamin D (25OHD), adiponectin, insulin, glucose, total cholesterol, HDL-cholesterol, triglyceride (TG), and androgens were measured in fasting blood samples. Results. Adiponectin (8.4 ± 2.7 ng/mL versus 13.6 ± 5 ng/mL in control group, P : 0.00), calcium (2 ± 0.1 mmol/L versus 2.55 ± 0.17 mmol/L in controls, P : 0.00), and 25-OH-Vit D (30 ± 2.99 nmol/L versus 43.7 ± 5.2 nmol/L in control group, P : 0.00) levels were decreased in women with PCOS. Subjects with PCOS had higher concentrations of TG (1.4 ± 0.77 mmol/L versus 1.18 ± 0.75 mmol/L in control group, P : 0.019) and dehydroepiandrosterone sulfate (DHEA-S) (10.7 ± 11 mmol/L versus 9.7 ± 10.4, P : 0.02 in control group). There were significant correlations between adiponectin concentrations with calcium (r : 0.78, P : 0.00) and 25OHD levels (r : 0.82, P : 0.00). The association of hypoadiponectinemia and PCOS was not significant considering 25OHD as a confounding factor. Conclusion. The present findings indicate that the association of hypoadiponectinemia with PCOS is dependent on vitamin D. A possible beneficiary effect of vitamin D on the metabolic parameters in PCOS may be suggested.

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“…In previous studies addressing the topic, the relationship between adiponectin and PCOS has been controversial, though a large proportion of such studies9-13) have shown that low adiponectin levels were found in the PCOS group when compared to the control group. And it is unclear so far whether adipo nectin is a primary defect or occurred secondary to or in parallel with this insulin resistance 11-14,17).…”

Section: Discussionmentioning

confidence: 99%

Adiponectin in Women with Polycystic Ovary Syndrome

Shin

Lee

2011

Korean J Fam Med

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BackgroundThough adiponectin has been associated with insulin resistance and cardiovascular risk factors, the relationship between adiponectin and polycystic ovary syndrome (PCOS) remains controversial. The aim of this study was to compare adiponectin level in women with PCOS and without PCOS, and to investigate the relationship between adiponectin level and metabolic variables including insulin resistance.Methods60 women with PCOS were enrolled along with a control group of 80 healthy women, matched for age and body mass index (BMI). We measured hormonal and metabolic parameters, as well as the plasma adiponectin concentration of each participant. We estimated the insulin sensitivity according to the quantitative insulin sensitivity check index (QUICKI).ResultsThe PCOS group displayed significantly lower level of adiponectin (P < 0.001) after adjustment for age, BMI, mean blood pressure, fasting glucose, fasting insulin, and several metabolic parameters. Adiponectin levels were positively correlated with QUICKI in the PCOS group (P < 0.001) and the control group (P = 0.03). Following step-wise multiple regression analysis, however, adiponectin level was positively correlated with QUICKI in the control group only (P = 0.03). In addition, adiponectin level was found to be independently associated with HDL-cholesterol level (P < 0.001) and BMI (P = 0.02) in the PCOS group and independently associated with HDL-cholesterol (P = 0.02) in the control group.ConclusionWe report decreased adiponectin level in PCOS patients in relation to controls independently of insulin resistance or other metabolic factors. And adiponectin is associated with both lipid metabolism and obesity, which, in turn, is related to insulin resistance in PCOS. Further studies are needed to clarify the mechanism of adiponectin in PCOS.

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Decreased Adiponectin Levels in Polycystic Ovary Syndrome, Independent of Body Mass Index

Abstract: Adiponectin levels were reduced in all the women with PCOS. There seemed to be an interaction between adiponectin and PCOS pathogenesis that was independent of body mass index.

Cited by 16 publications

References 42 publications

Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome

Role of adiponectin and its receptor in prediction of reproductive outcome of metformin treatment in patients with polycystic ovarian syndrome

Association between Hypoadiponectinemia and Low Serum Concentrations of Calcium and Vitamin D in Women with Polycystic Ovary Syndrome

Adiponectin in Women with Polycystic Ovary Syndrome

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