Decrease of superoxide dismutase and glutathione peroxidase in liver of rats treated with hypolipidemic drugs

Ciriolo, Maria Rosa; Mavelli, Irene; Rotilio, Giuseppe; Borzatta, Valerio; Cristofari, Manlio; Stanzani, Luciano

doi:10.1016/0014-5793(82)80651-0

Cited by 49 publications

(15 citation statements)

References 20 publications

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“…In addition, no significant difference in GSH concentration, a substrate of GSH-Px, was observed among the three groups. SOD and GSHPx activities are reported to be decreased by hypolipidemic drugs such as clofibrate (24). Although a decrease in plasma TG and T-CHO was observed in rats fed the natto fractions, no decrease in antioxidant enzymatic activity was observed in our study.…”

Section: Resultscontrasting

confidence: 84%

Antioxidative Functions of Natto, A Kind of Fermented Soybeans: Effect on LDL Oxidation and Lipid Metabolism in Cholesterol-Fed Rats

Iwai

Nakaya²,

Kawasaki³

et al. 2002

J. Agric. Food Chem.

102

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Natto water-soluble fractions, low-molecular-weight viscous substance, and soybean water extract, which had an inhibitory effect on the oxidation of low-density lipoproteins (LDL) in vitro, were fed to rats for 3 weeks. These fractions had no influence on the growth of rats, which were fed a basal diet containing 1% cholesterol, but lowered plasma triglyceride and total cholesterol. Inhibition of copper-oxidation of plasma and LDL ex vivo, and a reduction in lipid peroxidation in liver and aorta in vivo, were also observed. The antioxidant enzymes were not induced in rats fed natto fraction diets. These results demonstrate that ingestion of the natto fractions led to inhibition of LDL oxidation, and that the fractions perform direct antioxidant action in the body. It is suggested that natto fractions might help to prevent arteriosclerosis, as they appear to reduce lipid peroxidation and improve lipid metabolism.

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Section: Resultscontrasting

confidence: 84%

Antioxidative Functions of Natto, A Kind of Fermented Soybeans: Effect on LDL Oxidation and Lipid Metabolism in Cholesterol-Fed Rats

Iwai

Nakaya²,

Kawasaki³

et al. 2002

J. Agric. Food Chem.

102

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“…However the task is simplified somewhat because several laboratories have studied the effect of peroxisome proliferators on the major antioxidant systems in liver. Contrary to the expectations raised by our work, in most of these studies little or no change was seen in the hepatic levels of such antioxidant defense proteins such as catalase [60,61]; glutathione peroxidase [13,62]; glutathione reductase [63]; and superoxide dismutase [13,64].…”

Section: Discussioncontrasting

confidence: 53%

Clofibrate pretreatment in mice confers resistance against hepatic lipid peroxidation

Nicholls-Grzemski

Belling

Priestly³

et al. 2000

J. Biochem. Mol. Toxicol.

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“…In addition, peroxisome proliferators also stimulate some extraperoxisomal enzymes (succinate dehydrogenase, lactate dehydrogenase, b-N acetyl glucosaminidase) ( Figure 5) (8), or inhibit the synthesis of other enzymes (glutathione peroxidase, superoxide dismutase) (15).…”

Section: Biological Effect Of Peroxisome Proliferators In Livermentioning

confidence: 99%

Peroxisome Proliferators: Their Biological and Toxicological Effects

Dzhekova-Stojkova

Bogdanska²,

Stojkova³

2001

Clinical Chemistry and Laboratory Medicine

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One of the most rapidly developing areas of organelle biology, which has a major involvement in biochemical pharmacology, is the research into the peroxisomal function. There is a large group of compounds that are capable of inducing liver enlargement, proliferation of peroxisomal structures, and induction of peroxisomal and extraperoxisomal fatty acid-oxidizing enzymes in rodent liver, called peroxisome proliferators. This list includes hypolipidemic drugs, analgesics, uricosuric drugs, environmental pollutants, phthalates, etc. Some peroxisome proliferators have also been shown to increase the incidence of liver tumors. This review describes the characteristics of peroxisome proliferation in rodent liver and gives examples of different classes of chemicals that produce this effect. Mechanisms of initiation of peroxisome proliferation in rodent hepatocytes, including peroxisome proliferator-activated receptors, are also described. Rodent peroxisome proliferators are not considered to be genotoxic agents. Proposed mechanisms of liver tumor formation include induction of sustained oxidative stress, enhanced cell replication, promotion of spontaneous preneoplastic lesions, and inhibition of apoptosis. In addition, the absence of effects of peroxisome proliferators on peroxisome proliferator-associated parameters supports the hypothesis that human liver cells are refractory to peroxisome proliferator-induced hepatic carcinogenesis.

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Decrease of superoxide dismutase and glutathione peroxidase in liver of rats treated with hypolipidemic drugs

Cited by 49 publications

References 20 publications

Antioxidative Functions of Natto, A Kind of Fermented Soybeans: Effect on LDL Oxidation and Lipid Metabolism in Cholesterol-Fed Rats

Antioxidative Functions of Natto, A Kind of Fermented Soybeans: Effect on LDL Oxidation and Lipid Metabolism in Cholesterol-Fed Rats

Clofibrate pretreatment in mice confers resistance against hepatic lipid peroxidation

Peroxisome Proliferators: Their Biological and Toxicological Effects

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