Decrease of Ocular Pressure With Oral Metyrapone

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…Metyrapone can decrease ocular pressure and aqueous humor flow, and decreased levels of plasma cortisol are associated with a decrease in ocular pressure. 23,24 Patients with Cushing's syndrome with increased plasma cortisol have been identified as 2 basic types-one primarily ACTH dependent with increased pituitary production of ACTH and, thus, cortisol. 25 The other type is primarily adrenal in origin with the increased plasma cortisol independent of ACTH.…”

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…Metyrapone can decrease ocular pressure and aqueous humor flow, and decreased levels of plasma cortisol are associated with a decrease in ocular pressure. 23,24 Patients with Cushing's syndrome with increased plasma cortisol have been identified as 2 basic types-one primarily ACTH dependent with increased pituitary production of ACTH and, thus, cortisol. 25 The other type is primarily adrenal in origin with the increased plasma cortisol independent of ACTH.…”

Oral administration of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor RO5093151 to patients with glaucoma: an adaptive, randomised, placebo-controlled clinical study

“…Published results from oral administration of the non-selective 11βHSD1 and 11βHSD2 inhibitor carbenoxolone 8 and the cortisol biosynthesis inhibitor metyrapone 14 were promising in supporting the rationale that a selective and potent inhibition of 11βHSD1 may achieve clinically relevant reductions in IOP following oral administration ( table 1 ).…”

Long-term Reliability of Diurnal Intraocular Pressure Patterns in Healthy Asians

“…However, IOP varies throughout the day and has a circadian rhythm in both glaucomatous and non-glaucomatous eyes [456789]. The reason for diurnal IOP fluctuation is not known exactly but may be partly explained by the body posture changes associated with blood pressure and episcleral venous pressure changes [461011121314], diurnal fluctuations in cortisol level [151617], aqueous production changes over the day [1718], environmental light and dark cycle [192021], and seasonal inf luence [2223]. Although many scholars have investigated repeatable diurnal IOP variation [242526], some clinicians still doubt the comparison between pretreatment and posttreatment IOPs and the ability to assess the IOP-lowering effect of glaucoma drugs [27282930].…”

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…Metyrapone can decrease ocular pressure and aqueous humor flow, and decreased levels of plasma cortisol are associated with a decrease in ocular pressure. 23,24 Patients with Cushing's syndrome with increased plasma cortisol have been identified as 2 basic types-one primarily ACTH dependent with increased pituitary production of ACTH and, thus, cortisol. 25 The other type is primarily adrenal in origin with the increased plasma cortisol independent of ACTH.…”

Oral administration of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor RO5093151 to patients with glaucoma: an adaptive, randomised, placebo-controlled clinical study

“…Published results from oral administration of the non-selective 11βHSD1 and 11βHSD2 inhibitor carbenoxolone 8 and the cortisol biosynthesis inhibitor metyrapone 14 were promising in supporting the rationale that a selective and potent inhibition of 11βHSD1 may achieve clinically relevant reductions in IOP following oral administration ( table 1 ).…”

Long-term Reliability of Diurnal Intraocular Pressure Patterns in Healthy Asians

“…However, IOP varies throughout the day and has a circadian rhythm in both glaucomatous and non-glaucomatous eyes [456789]. The reason for diurnal IOP fluctuation is not known exactly but may be partly explained by the body posture changes associated with blood pressure and episcleral venous pressure changes [461011121314], diurnal fluctuations in cortisol level [151617], aqueous production changes over the day [1718], environmental light and dark cycle [192021], and seasonal inf luence [2223]. Although many scholars have investigated repeatable diurnal IOP variation [242526], some clinicians still doubt the comparison between pretreatment and posttreatment IOPs and the ability to assess the IOP-lowering effect of glaucoma drugs [27282930].…”

Decreased Response of Plasma Cortisol to Intravenous Metyrapone in Ocular Hypertension and Primary Open-Angle Glaucoma

“…Metyrapone can decrease ocular pressure and aqueous humor flow, and decreased levels of plasma cortisol are associated with a decrease in ocular pressure. 23,24 Patients with Cushing's syndrome with increased plasma cortisol have been identified as 2 basic types-one primarily ACTH dependent with increased pituitary production of ACTH and, thus, cortisol. 25 The other type is primarily adrenal in origin with the increased plasma cortisol independent of ACTH.…”

Oral administration of the 11β-hydroxysteroid-dehydrogenase type 1 inhibitor RO5093151 to patients with glaucoma: an adaptive, randomised, placebo-controlled clinical study

“…Published results from oral administration of the non-selective 11βHSD1 and 11βHSD2 inhibitor carbenoxolone 8 and the cortisol biosynthesis inhibitor metyrapone 14 were promising in supporting the rationale that a selective and potent inhibition of 11βHSD1 may achieve clinically relevant reductions in IOP following oral administration ( table 1 ).…”

Long-term Reliability of Diurnal Intraocular Pressure Patterns in Healthy Asians

“…However, IOP varies throughout the day and has a circadian rhythm in both glaucomatous and non-glaucomatous eyes [456789]. The reason for diurnal IOP fluctuation is not known exactly but may be partly explained by the body posture changes associated with blood pressure and episcleral venous pressure changes [461011121314], diurnal fluctuations in cortisol level [151617], aqueous production changes over the day [1718], environmental light and dark cycle [192021], and seasonal inf luence [2223]. Although many scholars have investigated repeatable diurnal IOP variation [242526], some clinicians still doubt the comparison between pretreatment and posttreatment IOPs and the ability to assess the IOP-lowering effect of glaucoma drugs [27282930].…”