2012
DOI: 10.5603/fhc.2012.0024
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Abstract: Salivary lactoferrin is a glycoprotein involved in the elimination of pathogens and the prevention of massive overgrowth of microorganisms that affect oral and general health. A high concentration of lactoferrin in saliva is often considered to be a marker of damage to the salivary glands, gingivitis, or leakage through inflamed or damaged oral mucosa, infiltrated particularly by neutrophils. We conducted a study to determine the effect of chronic alcohol intoxication on salivary lactoferrin concentration and … Show more

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Cited by 29 publications
(16 citation statements)
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“…Smoking has been associated with decreased secretion of salivary proteins, impairment of the mechanisms of both innate and acquired immunity such as phagocytosis, chemotaxis of neutrophils (even in occasional smokers), increased production of peroxides, impaired function and proliferation of B and T lymphocytes, and reduced levels of immunoglobulin G [13]. It has been shown that concomitant alcohol abuse and cigarette smoking resulted in a synergistic increase in the concentration of acetaldehyde in the saliva [2,14].…”
Section: Resultsmentioning
confidence: 99%
“…Smoking has been associated with decreased secretion of salivary proteins, impairment of the mechanisms of both innate and acquired immunity such as phagocytosis, chemotaxis of neutrophils (even in occasional smokers), increased production of peroxides, impaired function and proliferation of B and T lymphocytes, and reduced levels of immunoglobulin G [13]. It has been shown that concomitant alcohol abuse and cigarette smoking resulted in a synergistic increase in the concentration of acetaldehyde in the saliva [2,14].…”
Section: Resultsmentioning
confidence: 99%
“…In alcohol abusers and smokers, there have been reported disturbed function of the salivary glands with concomitant decrease in the secretion of salivary proteins, impairment in the immune mechanisms such as phagocytosis, chemotaxis, increased production of peroxides, and impaired function and proliferation of B and T lymphocytes and production of immunoglobulins [3,8,15]. People who chew tobacco have decreased levels of lysozyme and lactoferrin and increased secretion of immunoglobulin A in their saliva [9,10], which indicates reduced innate and activated acquired immunity of the saliva. Persons addicted to alcohol have been reported to have lower output of lactoferrin (non-smokers) [10] and immunoglobulin A (smokers) [9], which, together with the reduced output of lysozyme in our study, indicated suppression of immunity mediators present in the saliva.…”
Section: Resultsmentioning
confidence: 99%
“…People who chew tobacco have decreased levels of lysozyme and lactoferrin and increased secretion of immunoglobulin A in their saliva [9,10], which indicates reduced innate and activated acquired immunity of the saliva. Persons addicted to alcohol have been reported to have lower output of lactoferrin (non-smokers) [10] and immunoglobulin A (smokers) [9], which, together with the reduced output of lysozyme in our study, indicated suppression of immunity mediators present in the saliva. Generally, both alcohol abuse and cigarette smoking produce a synergistic increase in the concentration of acetaldehyde in the saliva [9].…”
Section: Resultsmentioning
confidence: 99%
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