volume 87, issue 3, P356-361 2010
DOI: 10.1038/clpt.2009.293
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Comment 2010-5-5Has erratum 2011-1
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Abstract: AbstractForged in the early 1960s, the paradigm for pharmaceutical innovation has remained virtually unchanged for nearly 50 years. During a period when most other research-based industries have made frequent and often sweeping modifications to their R&D processes, the pharmaceutical sector continues to utilize a drug development process that is slow, inefficient, risky, and expensive. Few who work in or follow the activities of the pharmaceutical industry question whether change is coming. They know that the…

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