Decoding Neurodevelopment: Findings on Environmental Exposures and Synaptic Plasticity

Croft, Cindy

doi:10.1201/b18030-9

Cited by 21 publications

(32 citation statements)

References 19 publications

(18 reference statements)

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“…Numerous methods have been employed to try to determine ASD susceptibility genes which include chromosomal studies, linkage studies and gene association studies [8]. Candidate autism susceptibility genes have been identified at multiple loci, most consistently on chromosomes 2q, 7q, 15q [11][12][13], 17q and 16p with the most consistent positive results coming from 7q [18,19]. Although the numerous genetic studies conducted on ASD have been successful in identifying potential chromosomal abnormalities, truncations and missense mutations, the detection of the specific genetic variants responsible for ASD have been mostly elusive, likely due to the high genetic complexity and probable heterogeneity of the disorder [8].…”

Section: Genetic Analysis Of Asdmentioning

confidence: 99%

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Environmental Influences on Biochemistry in Autism Spectrum Disorder

Wormwood¹,

Dupree²,

Darie³

et al. 2014

Autism Open Access

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Section: Genetic Analysis Of Asdmentioning

confidence: 99%

“…Along with genetic factors, environmental factors may play a role in causing ASD, due to the delicate sensitivity of the developing human brain to toxic chemicals [18,25]. Autistic children show signs of oxidative stress [26] and impaired methylation [25].…”

Section: Environmental Influences On Asdmentioning

confidence: 99%

Environmental Influences on Biochemistry in Autism Spectrum Disorder

Wormwood¹,

Dupree²,

Darie³

et al. 2014

Autism Open Access

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“…Considerable evidence suggests that neurocognitive disorders result from complex interactions of genetic, environmental and social factors [158]. The developing human brain is exquisitely sensitive to toxic chemicals [150] and early-life exposure to environmental toxicants has major impacts on neurocognitive disorders. Substantial evidence links loss of cognition (IQ), dyslexia and attention deficit hyperactivity disorder to lead, methyl mercury, organophosphate and organochlorine insecticides, polychlorinated biphenyls, arsenic, manganese, polyaromatic hydrocarbons, BPA, brominated flame retardants, and perfluorinated compounds [150].…”

Section: Neurocognitive Disordersmentioning

confidence: 99%

“…In children, neurocognitive disorders, such as autism spectrum disorder, attention deficit hyperactivity disorder, mental retardation, dyslexia and other biological disorders of the brain, are common [150], with between 400 000 and 600 000 of the 4 million babies born each year in the USA affected. Globally, childhood behavioural disorders contribute 5.75 million disability-adjusted life-years, a substantial proportion of the total burden of disease.…”

Section: Neurocognitive Disordersmentioning

confidence: 99%

Early-life risk factors for chronic nonrespiratory diseases

et al. 2014

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We have witnessed a change in disease patterns contributing to the global burden of disease, with a shift from early childhood deaths due to the classic infectious communicable diseases to years lived with disability from chronic noncommunicable diseases. In both developing and developed countries, the years lived with disability attributable to chronic disease have increased: cardiovascular diseases by 17.7%; chronic respiratory disease by 8.5%; neurological conditions by 12.2%; diabetes by 30.0%; and mental and behavioural disorders by 5.0% over the past 20 years. Recognition of the contribution made by adverse environmental exposures in early life to noncommunicable diseases in later life is increasing. These earlylife exposures appear to contribute to both chronic respiratory and chronic nonrespiratory diseases. In this State of the Art article, we aim to examine early-life environmental exposures that have an epidemiological association with chronic nonrespiratory diseases, such as obesity and type II diabetes, cardiovascular disease, and neurocognitive and behavioural problems. We will highlight the potential overlap in environmental risks with respiratory diseases, and point out knowledge gaps and research opportunities. @ERSpublications Respiratory diseases are linked to obesity/diabetes/metabolic syndrome, CVD and neurocognitive/behavioural disorders

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“…Genetic factors alone account for no more than 30-40 % of all cases of neurodevelopmental disorders. US National Research Council estimated that 3 % of developmental disabilities are the direct result of exposure to environmental toxicants whereas another 25 % are the result of an interaction between environmental factors and inherited susceptibilities (National Research Council 2000a;Landrigan et al 2012).…”

mentioning

confidence: 99%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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Decoding Neurodevelopment: Findings on Environmental Exposures and Synaptic Plasticity

Cited by 21 publications

References 19 publications

Environmental Influences on Biochemistry in Autism Spectrum Disorder

Environmental Influences on Biochemistry in Autism Spectrum Disorder

Early-life risk factors for chronic nonrespiratory diseases

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

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