Declined <scp>hTERT</scp> expression of peripheral blood <scp>CD</scp>4<sup>+</sup> T cells in oral lichen planus correlated with clinical parameter

Zhang, Jing; Wei, Minghui; Li, Rui; Du, Ge-Fei; Zhou, Gang

doi:10.1111/jop.12399

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…Most studies investigating telomerase in autoimmune diseases have found increased telomerase activity or hTERT gene expression in disease versus healthy states (Katayama and Kohriyama, 2001;Kurosaka et al, 2001;Kurosaka et al, 2003;Kurosaka et al, 2006;Qi et al, 2013;Tarhan et al, 2008;Wu et al, 2000;Wu et al, 1999a;Yudoh et al, 1999). However, one study observed no difference (Vazirpanah et al, 2017) and two studies reported lower hTERT mRNA expression in patients compared to healthy controls (Tarhan et al, 2008;Zhang et al, 2016). Interestingly, differences in telomerase activity were observed between active and inactive disease (Katayama and Kohriyama, 2001), probably due to changes in inflammatory and oxidative stress levels.…”

Section: Autoimmune Disease and Telomerasementioning

confidence: 99%

Stress and immunosenescence: The role of telomerase

Punder

Heim

Wadhwa

et al. 2019

Psychoneuroendocrinology

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Chronic stress is associated with the accelerated aging of the immune system and represents a potent risk factor for the development and progression of a wide range of physical and mental disorders. The elucidation of molecular pathways and mechanisms underlying the link between stress and cellular aging is an area of considerable interest and investigation. In this context, telomere biology has emerged as a particularly attractive candidate mechanism. Several studies have linked immune cell telomere length with stress-related conditions and states, and also with several physical and mental disorders. Because the cellular reverse transcriptase enzyme telomerase is the primary regulator of telomere length (by adding telomeric DNA to telomeres and thereby attenuating telomere shortening), the understanding of its regulation and regulatory functions constitutes a prime target for developing strategies to prevent, attenuate or reverse the

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Section: Autoimmune Disease and Telomerasementioning

confidence: 99%

Stress and immunosenescence: The role of telomerase

Punder

Heim

Wadhwa

et al. 2019

Psychoneuroendocrinology

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“…The OLP patients were diagnosed according to the clinicopathologically modified WHO diagnostic criteria of OLP. 18 The exclusion criteria were as follows: cases with the age below 18 or above 70 years old; pregnant women; patients who suffered from oral lesions adjacent to metal crowns or amalgam fillings; individuals with other detectable oral lesions or systemic diseases, or received treatment 3 months before the sample collection. Patients receiving any medication that can cause lichenoid reactions such as antihypertensive drugs and oral hypoglycemics were also excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

Clinical Values of miR-23a-3p in Oral Lichen Planus and Its Role in Keratinocyte Proliferation and Inflammatory Response

Wang¹,

Hu²,

Li³

2021

JIR

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Purpose Oral lichen planus (OLP) is a chronic inflammatory disease occurring in the oral cavity, and several miRNAs have been identified to be involved in the disease progression and malignant transformation. This study investigated the expression changes of miR-23a-3p in OLP patients, and further explored its functional role in keratinocyte cell proliferation and inflammatory response. Patients and Methods Fifty buccal mucosal tissue samples were collected from OLP patients. HaCaT cells were cultured with lipopolysaccharides (LPS) to mimic the condition of OLP in vitro. RNA extraction and quantitative real-time PCR (qRT-PCR) were used for the measurement of miR-23a-3p levels. The cell viability and inflammation were detected by using cell counting kit-8 (CCK-8) and enzyme-linked immunosorbent assay (ELISA). The target gene of miR-23a-3p was verified by using luciferase reporter assay. Results Compared with the control group, miR-23a-3p was significantly downregulated in the buccal mucosal tissues of OLP patients, and a remarkably decreased level of miR-23a-3p was detected in patients with erosive OLP. ROC curve demonstrated the diagnostic value of miR-23a-3p for OLP with the AUC of 0.908, it can also distinguish erosive OLP from the non-erosive ones. MiR-23a-3p level was negatively associated with RAE (reticular, atrophic, erosive) score in OLP patients (r = −0.790, P < 0.001). The in vitro experiments indicated that overexpression of miR-23a-3p reversed the promotive effect of LPS on HaCaT cell proliferation and reduced the protein levels of TNF-α and IL-6. The cyclin D1 (CCND1) was a direct target gene of miR-23a-3p, it was overexpressed in OLP cell models. Conclusion MiR-23a-3p was at the low expression in OLP patients and showed close association with the disease severity. Overexpression of miR-23a-3p might inhibit keratinocyte proliferation and inflammatory response via targeting CCND1.

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Section: Autoimmune Disease and Telomerasementioning

confidence: 99%

Stress and immunosenescence: The role of telomerase

Punder

Heim

Wadhwa

et al. 2019

Psychoneuroendocrinology

View full text Add to dashboard Cite

Declined hTERT expression of peripheral blood CD4⁺ T cells in oral lichen planus correlated with clinical parameter

Abstract: A divergent hTERT pattern between CD4(+) and CD8(+) T cells was implicated in OLP. Decreased hTERT in CD4(+) T cells might be responsible for the immune dysfunction in OLP.

Cited by 8 publications

References 32 publications

Stress and immunosenescence: The role of telomerase

Stress and immunosenescence: The role of telomerase

Clinical Values of miR-23a-3p in Oral Lichen Planus and Its Role in Keratinocyte Proliferation and Inflammatory Response

Stress and immunosenescence: The role of telomerase

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Declined hTERT expression of peripheral blood CD4+ T cells in oral lichen planus correlated with clinical parameter

Abstract: A divergent hTERT pattern between CD4(+) and CD8(+) T cells was implicated in OLP. Decreased hTERT in CD4(+) T cells might be responsible for the immune dysfunction in OLP.

Cited by 8 publications

References 32 publications

Stress and immunosenescence: The role of telomerase

Stress and immunosenescence: The role of telomerase

Clinical Values of miR-23a-3p in Oral Lichen Planus and Its Role in Keratinocyte Proliferation and Inflammatory Response

Stress and immunosenescence: The role of telomerase

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Declined hTERT expression of peripheral blood CD4⁺ T cells in oral lichen planus correlated with clinical parameter