2017
DOI: 10.3168/jds.2016-11522
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Abstract: Bovine respiratory disease (BRD) is a multifactorial disorder responsible for severe economic losses in dairy and feedlot herds. Advances in next-generation sequencing mean that microbial communities in clinical samples, including non-culturable bacteria, can be characterized. Our aim was to evaluate the microbiota of the upper respiratory tract of healthy calves and calves with BRD using whole-genome sequencing (shotgun metagenomics). We performed deep nasopharyngeal swabs on 16 Holstein heifer calves (10 hea… Show more

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Cited by 50 publications
(60 citation statements)
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“…Bovine respiratory disease was diagnosed when the animal showed ≥2 of the following clinical signs: mucopurulent or purulent nasal discharge, cough, rectal temperature >39.5°C, respiratory rate >40 breaths/min, and increased cranioventral lung sounds or crackle. 6,17,18 The limits of the lung field were 12°i ntercostal space at iliac line and 11°intercostal space at sciatic line. Two experienced veterinarians on our research team performed the physical examinations in all cattle.…”
Section: Case Definitionmentioning
confidence: 99%
“…Bovine respiratory disease was diagnosed when the animal showed ≥2 of the following clinical signs: mucopurulent or purulent nasal discharge, cough, rectal temperature >39.5°C, respiratory rate >40 breaths/min, and increased cranioventral lung sounds or crackle. 6,17,18 The limits of the lung field were 12°i ntercostal space at iliac line and 11°intercostal space at sciatic line. Two experienced veterinarians on our research team performed the physical examinations in all cattle.…”
Section: Case Definitionmentioning
confidence: 99%
“…It is widely recognized that the upper respiratory tract microbiome provides a first line of defense against foreign invaders through competition, and interaction, with potential mucosal pathogens [11]. While the composition and development of the nasopharyngeal microbiota in feedlot cattle has been recently described [5, 10, 12, 13], there are no published studies describing lower respiratory tract microbial communities in feedlot cattle. Interestingly, until recently the lower respiratory tract in healthy humans has traditionally been considered as sterile using culture-dependent or conventional molecular techniques [14, 15].…”
Section: Introductionmentioning
confidence: 99%
“…As a result of these observations, it has been suggested that disturbances in NP microbial communities may contribute to the pathophysiology of BRD in feedlot cattle (12). Although several studies have investigated the bovine NP microbiota in the predisease and disease states (22)(23)(24), little information is available on the change of NP microbiota associated with clinical recovery from BRD. To help explore this gap in knowledge, we evaluated the effect of tilmicosin treatment on the NP microbiota of BRD-affected calves during first week of clinical recovery.…”
Section: Overall Taxonomic Classification and Diversity Of Np Microbiotamentioning
confidence: 99%